Synthesis process of neotame

Abstract

The invention discloses a synthesis process of neotame. The synthesis process comprises the following steps: adding aspartame into a reaction container, performing water-bath heating to 33-35 DEG C, further adding 3,3-dimethyl butyraldehyde, heating to 30-60 DEG C, performing heat preservation reaction for 55-70 minutes, then adding a catalyst at the temperature, and introducing hydrogen for reacting for 14-16 hours; after the end of the reaction, filtering the catalyst to get filtrate, further washing the catalyst with an appropriate amount of methanol, merging the filtrate and washing liquid, performing vacuum distillation at the temperature of 40-50 DEG C, distilling obtained solids, further adding water, cooling, crystallizing, filtering at the temperature of less than 5 DEG C, drying and crushing to get a crude product; and adding 15-40% ethanol into the crude product, drying and crushing to get a final neotame finished product. According to the synthesis process of the neotame, the yields of the crude product and the finished product are greatly improved, the yield of the crude product can be improved from the current 70-72% to above 90%, the yield of the finished product can be improved from the current about 65% to above 80%, and the quality of the finished product has no difference in comparison with that of the finished product synthesized by the prior art.

Description

technical field [0001] The invention relates to neotame, specifically a neotame synthesis process, and belongs to the technical field of neotame synthesis. [0002] Background technique [0003] Neotame has extremely high sweetness, pure sweet taste, good stability under various conditions, and is safe and harmless to human body. It is a kind of non-nutritional strong sweetener with excellent performance. Neotame synthesis methods include chemical synthesis and chemical-enzyme combined synthesis, both of which involve catalytic hydroalkylation reactions. Due to the sufficient supply and stable price of aspartame, neotame is currently the main synthesis method using aspartame as raw material to prepare neotame through hydroalkylation. In addition to aspartame, the main raw materials involved in the neotame synthesis process currently include 3.3-dimethylbutyraldehyde. The synthesis process is roughly as follows: first add aspartame and 3.3-dimethylbutyraldehyde into a close...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the deficiency of low yield in the existing neotame synthesis process, the object of the present invention is to provide a neotame synthesis process with significantly improved yield