Space-induced efficient cordyceps fungus and application thereof as well as preparation method of capsule preparation of space-induced efficient cordyceps fungus

Abstract

The invention relates to a high-efficiency Cordyceps sinensis fungus for space mutation, its application and a preparation method of its capsule preparation. Conventional mutagenesis technology to screen Cordyceps sinensis suitable for fermentation production is not only inefficient, but also needs to mutagenize a large number of original strains, the variation range is small, and it is difficult to increase the yield of the target product Cordyceps polysaccharide in the fermentation product on a large scale. The invention provides Cordyceps sinensis S7-T8, which can be applied to the preparation of medicines and health products for enhancing immunity and anti-fatigue. The Cordyceps sinensis fungus described in the present invention has genetically changed the genetic characteristics of the strain, compensated for the "phenotype delay" and "genetic segregation phenomenon" caused by conventional mutagenesis, quickly obtained high-quality strains and ensured the stability of the strains It can increase the yield of strains on a large scale, and the content of polysaccharides and cordycepic acid in the strains of Cordyceps sinensis is greatly increased, which can be used for large-scale production.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a high-efficiency space-mutated Cordyceps sinensis, its application and a preparation method for capsule preparations. Background technique [0002] Cordyceps sinensis is a medicinal fungus belonging to the genus Cordyceps of the family Ascomycetes Ergotaceae. It is a traditional precious nourishing Chinese herbal medicine. It is recorded in the traditional medicine "Materia Medica Congxin" that "Cordyceps sinensis is sweet and warm in nature, secrets essence and nourishes qi, and is specially used to nourish the gate of vital energy." Modern medical research has confirmed that its ingredients contain cordycepic acid, cordycepin, amino acids, sterols, mannitol, alkaloids, vitamin B 1 , B 2 , polysaccharides and minerals, etc., have the functions of regulating immune system function, anti-fatigue, sedative hypnosis, anti-cancer, antibacterial, nourishing lung and kidney,...

AI Technical Summary

Problems solved by technology

However, as a unique and rare medicinal material that only grows in the Qinghai-Tibet Plateau region, the growth conditions are very harsh. At present, natural wild resources are increasingly scarce due to over-exploitation, which can no longer meet people's needs. Sexual stage, high technical content, low yield of active ingredients Cordyceps polysaccharide and cordycepic acid, not suitable for large-scale production needs

[0005] The large-scale acquisition of Cordyceps sinensis mycelium by fermentation technology can meet the needs of large-scale production, but the method of screening Cordyceps sinensis strains suitable for fermentation production by conventional mutagenesis technology is inefficient, and a large number of original strains need to be mutated, and conventional The mutation range of the strains screened out by mutagenesis is small, and it is difficult to increase the yield of the target product Cordyceps polysaccharide in the fermentation product on a large scale

In addition, conventional mutagenesis will have a "phenotype delay" effect, that is, the contemporary strains do not show the advantages of increased yield, cannot be selected in time, and are easily discarded, and are prone to "genetic segregation", that is, the mutant strains do not Stable and cannot be used for long-term large-scale production of Cordyceps sinensis strains

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