High-efficiency ganoderma lucidum induced by space mutation, its application and preparation method of capsule preparation

Abstract

The invention relates an efficient space-mutagenesis ganoderma lucidum, application thereof and a preparation method of capsule preparation of the efficient space-mutagenesis ganoderma lucidum. The problem that conventional mutagenesis performed on ganoderma lucidum bacterial strains is low in efficiency and smaller in variation extent as large quantities of original bacterial strains are in need of mutagenesis is solved, so that productive rate of outcome of ganoderma lucidum polysaccharides in fermentation products can hardly be increased on a large scale. The ganoderma lucidum S7-T7 is applicable to preparation of medicines and healthcare products functioning in oxidation resistance and immunity enhancement. Compared with conventional bacterial strains, the ganoderma lucidum bacterial strains have the advantages that a hereditary character of the bacterial strains is changed genetically, 'genetic separation phenomenon' and 'phenotypic lag' brought by the conventional mutagenesis are compensated, high-quality bacterial strains can be rapidly obtained, stability of the bacterial strains can be guaranteed, productive rate of the bacterial strains can be increased on a large scale, and production does not need to be increased by large-scale optimization experiment upon fermentation conditions.

Description

technical field [0001] The invention relates to the technical field of microorganisms, in particular to a ganoderma lucidum with high efficiency for space mutation, its application and a preparation method of capsule preparation. Background technique [0002] Ganoderma lucidum is a medicinal fungus belonging to the genus Ganoderma lucidum in the family Polyporaceae Basidiomycetes. In ancient China, Ganoderma lucidum was listed as a top-grade medicine. It is recorded in the drug monograph "Shen Nong's Materia Medica": Ganoderma lucidum has six kinds of purple, red, green, yellow, white, and black, and its nature and taste are sweet and flat. [0003] Modern pharmacological research has proved that Ganoderma lucidum has a wide range of pharmacological effects, such as anti-tumor effect, liver protection and detoxification, coronary artery expansion and myocardial microcirculation improvement, sedative effect, anti-aging effect, anti-neurasthenia effect, etc. The chemical com...

AI Technical Summary

Problems solved by technology

Using the screening model resistant to feedback inhibition of Ganoderma lucidum polysaccharides, screening and optimizing the conditions required for the fermentation process of strains, the process is cumbersome, the strains cannot be fundamentally modified, and the increase in yield is limited

However, conventional mutagenesis of bacterial strains, such as ultraviolet or microwave mutagenesis, is inefficient. If one wants to obtain high-efficiency ganoderma lucidum strains, a large number of original bacterial strains need to be mutagenized, and the strains screened out by this method have a relatively low variation range. Small, it is difficult to increase the yield of the target product Ganoderma lucidum polysaccharide in the fermentation product on a large scale

In addition, conventional mutagenesis will have a "phenotype delay" effect, that is, the contemporary strains do not show the advantages of increased yield, cannot be selected in time, and are easily discarded, and are prone to "genetic segregation", that is, the mutant strains do not Unstable and cannot be used for long-term large-scale production of Ganoderma lucidum strains

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