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Traditional Chinese medicine monomer combination capable of resisting oxidation and improving eyeground blood circulation

A monomer composition and anti-oxidation technology, which can be used in drug combinations, medical preparations containing active ingredients, anti-toxins, etc., and can solve the problem of BBB permeability reduction and other issues

Active Publication Date: 2013-09-18
HARBIN MEDICAL UNIVERSITY
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, after the administration of paeoniflorin, the permeability of the BBB decreased, which was significantly different from that of the model control group, indicating that paeoniflorin can improve the physiological function of the BBB. The blood-retinal barrier of the retina is the same as the BBB in terms of tissue source and physiological function, so it can be It is believed that paeoniflorin can also improve the blood-retinal barrier, which is of great significance for the improvement of retinal vascular diseases

Method used

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  • Traditional Chinese medicine monomer combination capable of resisting oxidation and improving eyeground blood circulation
  • Traditional Chinese medicine monomer combination capable of resisting oxidation and improving eyeground blood circulation
  • Traditional Chinese medicine monomer combination capable of resisting oxidation and improving eyeground blood circulation

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Embodiment Construction

[0020] The above and other technical features and advantages of the present invention will be described in more detail below in conjunction with examples and test data.

[0021]The present invention uses the diabetic rat (Wista) model to feed the diabetic rats with the four main monomer components of the traditional Chinese medicine "Siwu Decoction" for 12 weeks, and observes its influence on malondialdehyde (MDA) in the retinal tissue , using the orthogonal experiment to screen out the optimal dose of the traditional Chinese medicine monomer component prescription, and using the above optimal prescription to raise the diabetic rats again for 12 weeks, then observe the retinal tissue with a perspective electron microscope, mainly to observe the structure of visual cells and the ultrastructure of retinal capillaries Variety. In this study, the optimal ratio of ligustrazine=80mg / kg / d, catalpol=7mg / kg / d, ferulic acid=40mg / kg / d, paeoniflorin=100mg / kg / d was obtained through the dia...

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Abstract

The invention relates to a traditional Chinese medicine monomer combination capable of resisting oxidation and improving eyeground blood circulation. The traditional Chinese medicine monomer combination comprises the following components in parts by weight: 1.5 to 6.0 parts of ligustrazine, 0.5 to 1.5 parts of catalpol, 1.5 to 6.0 parts of ferulic acid, and 3.0 to 15 parts of paeoniflorin. According to the traditional Chinese medicine monomer combination, the conventional processing method is adopted and used for preparing injection, oral liquid, capsules, troches and preparations of other forms based on the traditional Chinese medicine monomer. The traditional Chinese medicine monomer combination is mainly used for resisting oxidization and protecting free radicals, can prevent and delay the deformation and development of cataract and improve the eyeground blood circulation, also can treat uvea and retina vascular diseases and eye malnutritional lesion, nourish optic nerve and recover visual functions from glaucoma, traumatic optic nerve diseases and visual pathway diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine monomer composition for improving fundus blood circulation, nourishing optic nerve and restoring visual function. Background technique [0002] Due to "problems" such as unclear active ingredients and difficult control of quality control standards in the application of traditional Chinese medicine prescriptions, the internationalization of Chinese medicine is difficult. There is even a fallacy: Chinese medicine is a product of ignorance and backwardness and should be abolished. Even Lu Xun once said: "Chinese medicine is nothing but a liar, intentionally or unintentionally." The monomerization of traditional Chinese medicine seems to allow people to understand traditional Chinese medicine, and it also complies with the requirements of western medicine research-clear pharmacology and controllable quality and safety. People in the indust...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P27/02A61P27/12A61P27/06A61P39/06A61P9/10A61K31/4965A61K31/192
Inventor 白建海黄磊崔浩马燕利
Owner HARBIN MEDICAL UNIVERSITY
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