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Zedoary-cyclic-diolefine-containing pharmaceutical composition and pharmacy application thereof

A technology of turmeric cyclodiene and turmeric cyclodiene, which is applied in the field of pharmaceutical compositions containing turmeric cyclodiene, can solve the problems of poor stability, difficult drug absorption, low bioavailability and the like, and achieves easy acceptance and reduced Cost, effect of increasing solubility and stability

Inactive Publication Date: 2013-11-27
HANGZHOU MINSHENG PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Although the compound has a high solubility in oily medium, the emulsion or oil prepared by conventional methods has the characteristics of easy precipitation and poor stability, especially when it enters the body, the oil phase is immiscible with the body, the drug absorption is difficult, and the bioavailability is low. low disadvantage

Method used

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  • Zedoary-cyclic-diolefine-containing pharmaceutical composition and pharmacy application thereof
  • Zedoary-cyclic-diolefine-containing pharmaceutical composition and pharmacy application thereof
  • Zedoary-cyclic-diolefine-containing pharmaceutical composition and pharmacy application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: 1g zedoary cyclodiene

[0032] 50g soybean oil

[0033] 10g soybean lecithin

[0034] Add water for injection to the mark for a total of 1000ml

[0035]Preparation: First dissolve the emulsifier (soybean lecithin) in the oil phase (soybean oil), add the main drug zedoary cyclodiene, stir to dissolve, after stirring evenly, filter through a microporous membrane with a pore size of 0.22 μm for later use. Add water for injection to the prescribed amount, make colostrum with a homogenizer, and make it reach the particle size of the injection emulsion through the homogenizer. Sterile filtration was carried out through a microporous filter membrane with a pore size of 0.22 μm, and finally it was filled in a dry sterile ampoule of 1 ml. Make each ampule 1ml containing the emulsion injection of 1 mg of turmeric cyclodiene.

Embodiment 2

[0036] Example 2: 10 g of zedoary cyclodiene, 50 g of soybean oil, 20 g of soybean lecithin, and water for injection are added to a scale of 1000 ml in total.

[0037] The method for preparing the pomzocycladiene emulsion injection is the same as that in Example 1, and each ampoule is made into an emulsion injection containing 10 mg pomzocycladiene in 1 ml.

Embodiment 3

[0038] Example 3: 40 g of zedoary cyclodiene, 100 g of corn oil, 20 g of egg yolk lecithin, and water for injection were added to the mark to make a total of 1000 ml.

[0039] The method for preparing the pomzocycladiene emulsion injection is the same as that in Example 1, and each ampoule is made into an emulsion injection containing 40 mg pomzocycladiene in 1 ml.

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PUM

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Abstract

The invention provides a zedoary-cyclic-diolefine-containing pharmaceutical composition. A preparation of the composition is in a form of soft capsules. After entering into human gastric juice, the soft capsules is capable of promoting mixing of grease and in-vivo aqueous body fluid, improving the oil-water distribution property of the zedoary cyclic diolefine, promoting the speed and the degree of penetration of the zedoary cyclic diolefine through cytomembranes and improving the bioavailability of the preparation. In addition, toxicity of the soft capsules is lower than toxicity of general oral emulsions, thus improving pharmacological properties of the soft capsules.

Description

[0001] This application is a divisional application with the application number 200910101005.2, the filing date is July 29, 2009, and the invention title is "Pharmaceutical Composition Containing Curcuma Cyclodiene, Its Preparation Process and Its Medical Application". technical field [0002] The invention relates to active ingredients of traditional Chinese medicine, a pharmaceutical composition, a preparation method and a medical application. Specifically, the present invention relates to a pharmaceutical composition containing zedozoa cyclodiene and the pharmaceutical application thereof. Background technique [0003] Curcuma cyclodiene is a main component of curcuma oil, which was first reported by Hikiw, H et al. in Japan in 1968. Its chemical name is (5E,9Z)-3,6,10-trimethyl-4,7,8,11-tetrahydroaradeca[b]furan. [0004] The chemical structural formula is: [0005] [0006] The molecular formula is: C 15 h 20 The molecular weight of O is: 216.15 [0007] At prese...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/343A61K47/24A61K47/26A61P35/00
Inventor 孟昭珂郭殿武吴耀东
Owner HANGZHOU MINSHENG PHARMA RES INST
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