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Preparation method and application of breast lump dissipating tablet

A kind of breast block and supercritical technology, which is applied in the direction of medical preparations containing active ingredients, pharmaceutical formulas, anti-tumor drugs, etc., can solve the problems of large dosage for patients, affect the application, rough process, etc., and achieve the effect of reducing the dosage

Inactive Publication Date: 2014-01-08
侯俊光
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical technology in the extraction and preparation of Rukuaixiao Tablets. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take and seriously affects This product has been applied clinically

Method used

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  • Preparation method and application of breast lump dissipating tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 825g of orange leaves, 825g of salvia miltiorrhiza, 550g of saponins, 550g of wangbuliuxing, 550g of toosendan, and 550g of earthworm, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1m1 / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 500 tablets, each weighing 0.5g.

Embodiment 2

[0018] Take 825g of orange leaves, 825g of salvia miltiorrhiza, 550g of saponins, 550g of wangbuliuxing, 550g of toosendan, and 550g of earthworm, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained. Starch and 70% ethanol are added to make granules, dried, and pressed into tablets to make 1000 tablets, each weighing 0.5g.

Embodiment 3

[0020] Take 825g of orange leaves, 825g of salvia miltiorrhiza, 550g of saponins, 550g of wangbuliuxing, 550g of toosendan, and 550g of earthworm, and add them to CO 2 In the supercritical extractor, ethanol is used as entrainer, the volume percentage of entrainer in the total extraction solvent is 5%, extraction pressure is 20MPa, temperature is 40°C, CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained. Add starch and 70% ethanol to make granules, dry, and compress into tablets to make 1000 tablets, each weighing 0.5g. Example 4: Experimental Research Data of Rukuaixiao Tablets Inhibiting B16-F10 Cell Proliferation

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Abstract

The invention provides a preparation method of a breast lump dissipating tablet. The breast lump dissipating tablet is prepared from bulk drugs, including 825g of tangerine leaves, 825g of roots of red-rooted salvia, 550g of spina gleditsiae, 550g of seeds of cowherb, 550g of szechwan chinaberry fruit, and 550g of earthworms, through supercritical extraction, so that the content is improved greatly, and the dose is reduced. The invention also provides an application of the breast lump dissipating tablet in the preparation of medicines for inhibiting cell proliferation of mouse melanoma lung metastatic lines B16-F10.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of Rukuaixiao tablets. Background technique [0002] Rukuaixiao tablet is recorded in Pharmacopoeia, the prescription is 825g of orange leaves, 825g of salvia miltiorrhiza, 550g of saponins, 550g of wangbuliuxing, 550g of toosendan, and 550g of earthworm. Add water and decoct the remaining orange leaves and other four flavors twice, each time for 1 hour, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.25-1.30 (85°C), let it cool, and set aside; Dilong and Wangbuliuxing Reflux extraction with 70% ethanol twice, the first time for 2 hours, the second time for 1 hour, filter, combine the filtrate, add to the above concentrate, adjust the amount of ethanol to 70%, stir evenly, stand still, recover ethanol and concentrate To a thick paste, dry under reduced pressure to form a...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K9/20A61P15/14A61P35/04A61K35/56A61K35/62
Inventor 不公告发明人
Owner 侯俊光
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