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High-energy substances for preventing and treating senile neurodegenerative diseases and their medical applications

A neurodegenerative, high-energy technology, applied in the direction of nervous system diseases, neuromuscular system diseases, medical preparations containing active ingredients, etc.

Inactive Publication Date: 2017-07-25
陈铭
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the use of high-energy compounds for the treatment of neurodegenerative diseases

Method used

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  • High-energy substances for preventing and treating senile neurodegenerative diseases and their medical applications
  • High-energy substances for preventing and treating senile neurodegenerative diseases and their medical applications
  • High-energy substances for preventing and treating senile neurodegenerative diseases and their medical applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Example 1 tablet

[0107]

[0108] Excipients (corn starch 150g, croscarmellose 40g, microcrystalline cellulose 50g)

[0109] Make 1000 tablets, each 0.5g

Embodiment 2

[0110] Example 2 tablet

[0111]

[0112] Excipients (corn starch 100g, mannitol 75g, magnesium stearate 5g, sodium alginate 25g)

[0113] Make 1000 tablets, each 0.5g

Embodiment 3

[0114] Embodiment 3 injection powder

[0115] Phosphocreatine 50g, Acetyl Coenzyme A37.5g

[0116] Excipients (sorbitol 10g, polyethylene glycol 10g).

[0117]1000 bottles were prepared, each containing 50mg of creatine phosphate and 37.5mg of acetyl-CoA

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PUM

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Abstract

The present invention relates to a high-energy substance for senile neurodegenerative diseases. The high-energy substance includes phosphoenolpyruvate, phosphocreatine, acetyl-CoA, adenosine triphosphate, L-carnitine, S-adenosine A One or several high-energy compounds and derivatives of thionine, guanosine triphosphate, cytidine triphosphate, pyrophosphate, 1,3-diphosphoglycerate, succinyl-CoA. The beneficial effect of the present invention is that high-energy substances are found to be used for senile neurodegenerative diseases, especially for the elderly to delay and prevent dementia, and it is proved that the high-energy substances of the present invention are reasonable, safe and economical for the treatment of neurodegenerative diseases, especially New drugs for the prevention and treatment of Alzheimer's disease.

Description

technical field [0001] The invention belongs to the field of drug application for senile neurodegenerative diseases, in particular to a treatment of senile neurodegenerative diseases with high-energy substances. Background technique [0002] Neurodegenerative disease is a general term for a group of diseases caused by chronic progressive degeneration of central nervous tissue. The common pathology is degeneration and loss of neurons in the brain or (and) spinal cord. In the elderly population, mainly include Alzheimer's disease (Alzheimer's disease, AD) (Alzheimer's disease or senile dementia), cerebellar atrophy, multiple sclerosis, Parkinson's disease, primary lateral sclerosis, spinal cord muscular atrophy etc. [0003] There are few marketed drugs for senile neurodegenerative diseases, mainly including dopamine-mimetic drugs and cholinergic receptor blocking drugs for the treatment of Parkinson's disease, such as levodopa, carbidopa, seligiline, and enzymatic drugs. Ta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/661A61K31/664A61K31/7076A61K31/205A61K31/708A61K31/7068A61K33/42A61P25/28A61P21/00A61P19/10A61P9/10A61P25/16
Inventor 陈铭
Owner 陈铭
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