Application of gynura procumbens extracts to preparation of liver injury prevention and cure preparations

A technique for recumbent chrysanthemum Panax notoginseng and liver damage, which is applied in the field of medicine and achieves the effects of easy acceptance, liver protection and significant liver protection effects.

Active Publication Date: 2014-01-22
深圳市本源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant report on the use of Jusanqi in the treatment of liver damage

Method used

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  • Application of gynura procumbens extracts to preparation of liver injury prevention and cure preparations
  • Application of gynura procumbens extracts to preparation of liver injury prevention and cure preparations
  • Application of gynura procumbens extracts to preparation of liver injury prevention and cure preparations

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 extract

[0027] 1. Preparation of the extract from the stem of Pinghuo chrysanthemum notoginseng:

[0028] Pingwo chrysanthemum notoginseng is produced in Guangdong. The dried stems are weighed and crushed. Each time, 10 volume / weight times (L / kg) of 80v / v% ethanol is added, and the reflux extraction is performed at 85°C for 1 hour. A total of 3 extractions are combined. The extract was concentrated and dried, and the yield of dry extract (density 1.40g / L) was about 18.5%.

[0029] 2. The preparation of the extract of the leaves of chrysanthemum notoginseng:

[0030] Pingwo chrysanthemum notoginseng is produced in Guangdong. The dried leaves are weighed and crushed, and 10 volume / weight times (L / kg) of 50v / v% ethanol is added each time, and the extraction is refluxed at 90°C for 0.5h, and the extraction is 3 times in total. The extracts were combined and concentrated to dryness, and the yield of dry extract (density 1.40g / L) was about ...

Embodiment 2

[0033] Therapeutic effect of the extract from the stems of Panwort notoginseng prepared in Example 1 on the liver damage induced by diethylnitrosamine (DEN):

[0034] Male Kunming mice were divided into 4 groups: blank control group, DEN model group, flat-lying Jusanqi treatment group 1, and flat- lying Jusanqi treatment group 2, with 8 animals in each group. DEN model group, flat lying chrysanthemum notoginseng treatment group 1, flat lying chrysanthemum notoginseng treatment group 2, orally administered DEN (165mg / kg) once a week for 8 weeks, to build a DEN model, and flat lying chrysanthemum notoginseng treatment Group 1 and Group 2 were administered with 50 mg / kg and 200 mg / kg of the root extract prepared in Example 1, once a day, and after continuous administration for one week, the blood was collected from the eyeball, and the liver was collected after the animal was sacrificed. Blood samples were centrifuged to obtain serum, which was used to measure alanine aminotransf...

Embodiment 3

[0037] Therapeutic effect of the flat lying chrysanthemum notoginseng stem extract prepared in Example 1 on acetaminophen-induced liver damage in mice:

[0038] Male Kunming mice were divided into 5 groups: blank control group, acetaminophen model group, flat lying chrysanthemum notoginseng treatment group 1, flat lying chrysanthemum notoginseng treatment group 2, flat lying chrysanthemum notoginseng treatment group 3, 8 in each group only animals. Pingwo chrysanthemum notoginseng treatment group 1, Pingwo chrysanthemum notoginseng treatment group 2, and Pingwo chrysanthemum notoginseng treatment group 3 were given 50, 100, and 200 mg / kg of the chrysanthemum notoginseng stem extract prepared in Example 1 by intragastric administration, respectively. The blank control group and the acetaminophen model group were given the same amount of normal saline. After intragastric administration, the acetaminophen model group, the flat-lying chrysanthemum notoginseng treatment group 1, the...

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Abstract

The invention relates to the technical field of medicine, in particular to an application of gynura procumbens extracts to the preparation of liver injury cure or prevention preparations. According to the application, stem or leaf extracts of gynura procumbens are applied to the cure or prevention of liver injuries caused by alcohol, drugs or poison, a remarkable effect is achieved, and the curative effect is certain without a toxic or side effect; moreover, the extraction method is easy to implement, and the application prospect is broad.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of an extract of chrysanthemum notoginseng in the preparation of preparations for treating or preventing liver damage. Background technique [0002] Liver injury is one of the common clinical causes that endanger human health. Liver injury is the damage to the liver caused by the invasion of the liver by external harmful factors. Liver injury is divided into pathological liver injury and chemical liver injury. Chemical liver injury is liver injury caused by chemical hepatotoxic substances. These chemicals include alcohol, chemical toxins in the environment, and certain drugs. The source of the disease is hard to prevent, and the liver is easily damaged and difficult to detect. If liver damage is allowed to worsen and develop, it will eventually turn into cirrhosis, or even liver cancer, which will eventually be irreversible. Therefore, it is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P1/16
Inventor 唐和斌李小军李婷婷李玉桑
Owner 深圳市本源生物科技有限公司
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