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Anti-tumor effects of oxytetracycline, propafenone and dipyrone

An anti-tumor effect, propafenone technology, applied in the field of non-clinical anti-tumor drugs, can solve problems such as small toxic and side effects, achieve the effects of relieving the disease, large social and economic benefits, and inhibiting the progress of tumors

Inactive Publication Date: 2014-01-29
邵金辉
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  • Abstract
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AI Technical Summary

Problems solved by technology

At present, there is almost no drug that can completely cure cancer patients such as lung cancer or cervical cancer. Therefore, it is very important to find an effective, specific, and less toxic and side effect new anti-tumor drug

Method used

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  • Anti-tumor effects of oxytetracycline, propafenone and dipyrone
  • Anti-tumor effects of oxytetracycline, propafenone and dipyrone
  • Anti-tumor effects of oxytetracycline, propafenone and dipyrone

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Embodiment Construction

[0019] Taking oxytetracycline, propafenone and metamizole while treating clinical lung cancer patients with conventional antineoplastic drugs can inhibit tumor progression to a certain extent and alleviate the patient's condition. Clinically, patients with cervical cancer who are treated with conventional antineoplastic drugs, taking the highest dose allowed by propafenone, can inhibit the progression of the tumor to a certain extent and alleviate the patient's condition.

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Abstract

The invention relates to three non-clinical antitumor drugs which are found to have anti-tumor effects and mainly can inhibit the proliferation of lung cancer A549 cells or cervical cancer Hela cells. The technical problem to be solved is that some clinical drugs are screened by using the lung cancer A549 cells and the cervical cancer Hela cells, so as to obtain the non-clinical antitumor drugs with the antitumor effects. Key points of technical schemes for solving the problems are as follows: the lung cancer A549 cells and the cervical cancer Hela cells are processed for 48 hours by using drugs of saturated concentration, and the changes of the morphology and quantity of the cells are observed by a microscope; for drugs with inhibitory actions, survival rate and LDH (Lactate Dehydrogenase) activity detection is further carried out on the cells, and Hoechst33258 is applied to cell apoptosis detection. Main purposes: the non-clinical anticancer drugs for remarkably inhibiting the proliferation of the lung cancer A549 cells or cervical cancer Hela cells are found and are applied to the clinical treatment of patients with lung cancer or cervical cancer.

Description

technical field [0001] The present invention relates to the new functions of the anti-tumor effect of the three drugs. Specifically, the present invention relates to three non-clinical antitumor drugs, which are found to have antitumor effects, mainly to significantly inhibit the proliferation of lung cancer A549 cells or cervical cancer Hela cells. Background technique [0002] Clinical trials are the last step in the development of new drugs, and they cost huge sums of money. The new use of old drugs, especially the discovery of new uses of "old drugs" that have been used in long-term clinical practice, is of great significance, and its value is by no means lower than that of discovering a new drug. At present, there is almost no drug that can completely cure cancer patients such as lung cancer or cervical cancer. Therefore, it is very important to find an effective, specific, and less toxic and side effect new anti-tumor drug. [0003] Many new uses of old drugs are dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/65A61K31/4152A61K31/138A61P35/00
Inventor 邵金辉
Owner 邵金辉
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