Magnetically fluorescent bifunctional microspheres prepared by connection of polyaniline magnetic microspheres and fluorescent quantum dots

A fluorescent quantum dot, dual-functional technology, applied in the field of magnetic fluorescent dual-functional microspheres, can solve the problems of limitations, inability to separate and apply fluorescent markers, etc.

Inactive Publication Date: 2014-02-12
SUZHOU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

In this new type of particle called Magneto Fluor (MF) Micropars), there has been developed an improved version that combines two different properties into one material. One property being good for both types of lighting while another attribute improves their ability to collect or separate them easily without requiring complicated equipment like magnetization manipulation. These MOF'S microscopic materials hold out certain unique features when excited by strong electromagnetism. They may find use in various applications where they serve well beyond just detecting small objects within range from visible wavelengths up to infrared rays.

Problems solved by technology

This patented technical solution describes various methods for creation of magnetite microparticle composites containing quantum dods or quantum dices attached together through an ion exchange process between these components. By combining both magneisable and luminescing capabilities into this new type of particle, there could potentially provide improved functionality compared to existing techniques like those involving separate labels on individual atoms. Additionally, the use of quantum dot conjugates made up of specific unit chains allows for precise control over light emissions without affecting any substances' absorption ability. Overall, this method provides potential benefits across diverse areas including medicine science, chemotherapy, diagnostic testing, cancer treatment, and others.

Method used

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  • Magnetically fluorescent bifunctional microspheres prepared by connection of polyaniline magnetic microspheres and fluorescent quantum dots
  • Magnetically fluorescent bifunctional microspheres prepared by connection of polyaniline magnetic microspheres and fluorescent quantum dots
  • Magnetically fluorescent bifunctional microspheres prepared by connection of polyaniline magnetic microspheres and fluorescent quantum dots

Examples

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Effect test

Embodiment 1

[0049] Example 1Fe 3 o 4 Preparation of / CdSe / CdS Magnetic Fluorescent Bifunctional Nanocomposite Microspheres

[0050] 1. Prepare fluorescent quantum dots, and control the particle size to 2-10nm.

[0051] Taking cadmium selenide wrapped cadmium sulfide (CdSe / CdS) as an example, cadmium selenide wrapped cadmium sulfide (CdSe / CdS) was synthesized and modified. The specific preparation method is as follows:

[0052] CdSe quantum dots were synthesized in oil phase by literature method (Diao, X.L.; Xia, Y.S.; Zhang, T.L.; Li, Y.; Zhu, C.Q.J. Anal. Bioanal. Chem. 2007, 388, 1191). A certain amount of CdO was added to oleic acid and liquid paraffin, put into a three-neck flask and heated and stirred, and the CdO was dissolved at 150°C to form a uniform light yellow Cd solution. Put Se powder into liquid paraffin and stir quickly, heat to 220°C (in another three-neck flask), the solution first turns orange and then red. Gently inject the Cd solution into the Se solution while st...

Embodiment 2

[0061] Example 2Fe 3 o 4 Preparation of / CdTe Magnetic Fluorescent Bifunctional Nanocomposite Microspheres

[0062] The specific steps are roughly the same as those in Example 1, except that the quantum dots used are CdTe modified with thioglycolic acid.

[0063] (1) The preparation method of CdTe modified with thioglycolic acid is as follows:

[0064] 1. Preparation of Te precursor

[0065] Take 80mgTe powder and 50mgNaBH respectively 4 Add it to the vial, close the mouth of the bottle, and inject 1ml of distilled water with a syringe. Seal the mouth of the bottle with raw tape, and then insert a needle into the bottle stopper to make the H produced by the reaction 2 drain out. React the vial at 0°C for 8 hours, it can be observed that the black Te powder disappears, the upper layer is a colorless NaHTe solution, and the lower layer is NaHTe 2 B 4 o 7 White precipitate.

[0066] 2. Preparation of Cd precursor

[0067] Take 0.2854g (1.25×10-3mol) CdCl 2 2.5H 2 O w...

Embodiment 3

[0073] Example 3Fe 3 o 4 Properties of / CdSe / CdS Magnetic Fluorescent Bifunctional Nanocomposite Microspheres

[0074] The present embodiment obtains Fe with embodiment 1 3 o 4 / CdSe / CdS magnetic fluorescent bifunctional nanocomposite microspheres as an example to study some properties of the obtained nanocomposite microspheres. The luminescence and magnetic properties of fluorescent magnetic bifunctional microspheres were studied by transmission electron microscope, fluorescence microscope and magnetic property measurement.

[0075] image 3 It is the energy spectrum of the magnetic fluorescent bifunctional nanocomposite microsphere. Figure 4 for Fe 3 o 4 / CdSe / CdS magnetic fluorescent bifunctional nanocomposite microspheres real-time distribution photos and fluorescence microscope photos. Figure 5 for Fe 3 o 4 / CdSe / CdS magnetic fluorescent bifunctional nanocomposite microspheres transmission electron micrographs. The appearance and particle size of CdSe / CdS QDs...

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Abstract

The invention discloses magnetically fluorescent bifunctional microsphere and a preparation method thereof. The nanometer microspheres with the magnetically fluorescent function are obtained mainly by wrapping the surfaces of magnetic nanoparticles with polyaniline macromolecules and successfully connecting fluorescent nanometer material quantum dots through functional amino groups at the terminals of the polyaniline macromolecules. The magnetically fluorescent nanometer microspheres have the excellent fluorescence characteristics of the quantum dots and the superparamagnetism of the magnetic particles and can be collected and separated through a simple applied magnetic field. The magnetically fluorescent bifunctional microspheres can be applied to the fields of immunodetection, targeted therapy, cellular seperation and the like.

Description

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Claims

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Application Information

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Owner SUZHOU UNIV OF SCI & TECH
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