Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A preparation method and application of Tongjingcao extract

A technology of amenorrhea and extracts, applied in the preparation of medicines for preventing and treating diabetes, the preparation of Chinese herbal medicine extracts, and the field of preparation of amenorrhea extracts, which can solve the problem that the herbs or herbs have not yet been seen. The preparation of extracts to prevent and treat diabetes drug reports and other issues, to achieve the effects of low production cost, high safety, and definite curative effect

Inactive Publication Date: 2015-10-28
王珊 +1
View PDF8 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The above-mentioned documents and patents, etc., have not yet seen the report of Tongjingcao or Tongjingcao extract being used to prepare drugs for the prevention and treatment of diabetes

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A preparation method and application of Tongjingcao extract
  • A preparation method and application of Tongjingcao extract
  • A preparation method and application of Tongjingcao extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: Preparation of Tongjingcao Extract and Monomer Compounds

[0029] Put 20kg of Herbs japonica into the extraction tank, add 10 times the amount of 70% ethanol, extract twice at 70°C for 1 hour each time, combine the extracts, recover the ethanol, filter, combine the extracts, recover the ethanol, concentrate, dry, Obtain 100 g of Herbs’ Herbs Extract A6; dissolve 100 g of Herbs’ Herbs’ Extract A6 in 20 times the amount of water, and filter to obtain liquid A and precipitate A. The precipitate A was separated and purified by high-speed countercurrent chromatography (HSCCC) with n-hexane-ethyl acetate-methanol-water (2:2:3:2) as the solvent system, the solvent was recovered, concentrated and dried, and the general Herbal extract B250g; drug solution A, pass through HPD600 macroporous adsorption resin column, elute 2BV (resin column volume) with water, and then use ethanol solution with a concentration of 10-70% for gradient elution, and collect ethanol eluents w...

Embodiment 2

[0032] Example 2: Preparation of Tongjingcao Extract and Monomer Compounds

[0033] (1) Put 2 kg of Herba Trichonia into an extraction tank, use water as a solvent, and extract by warm soaking at 80°C. The number of extractions is 1 time, and the extraction time is 4 hours. The amount of solvent used each time is 15 times the weight of the medicinal material; filter, Combine the extracts, concentrate, and dry to obtain the extract A of Tongjingcao;

[0034] (2) Add 5 times the amount of water to dissolve the extract A obtained in step (1), and filter to obtain medicinal solution A and precipitate A. The precipitate A was separated and purified by high-speed countercurrent chromatography (HSCCC) with n-hexane-ethyl acetate-methanol-water (2:2:3:2) as the solvent system, the solvent was recovered, concentrated and dried, and the general Herbal Extract B;

[0035] (3) Pass the drug solution A obtained in step (2) through the NKA macroporous adsorption resin column, elute with w...

Embodiment 3

[0039] Example 3: Preparation of Tongjingcao Extract and Monomer Compounds

[0040] (1) Put 5 kg of Herbs through the extraction tank, use a concentration of 90% as a solvent, and extract by warm soaking at 20°C. The number of extractions is 3 times, and the extraction time for each time is 1 hour. The amount of solvent used each time is the weight of the medicinal material. 6 times; filter, combine the extracts, recover ethanol, concentrate, dry, and get the extract A of Tongjingcao;

[0041] (2) Add 20 times the amount of water to dissolve the extract A obtained in step (1), and filter to obtain medicinal solution A and precipitate A. The precipitate A was separated and purified by high-speed countercurrent chromatography (HSCCC) with n-hexane-ethyl acetate-methanol-water (2:2:3:2) as the solvent system, the solvent was recovered, concentrated and dried, and the general Herbal Extract B;

[0042] (3) Pass the drug solution A obtained in step (2) through an AB-8 macroporous...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method and application of an Aleuritopteris argentea Fee extract. The preparation method includes: extracting Aleuritopteris argentea Fee, then performing high-speed counter-current chromatography, macroporous adsorption resin and other chromatography purification to obtain an Aleuritopteris argentea Fee extract B and an Aleuritopteris argentea Fee extract C, mixing the Aleuritopteris argentea Fee extract B with the Aleuritopteris argentea Fee extract C in certain proportion, thus obtaining the Aleuritopteris argentea Fee extract, which can be combined with a pharmaceutically acceptable carrier or other suitable excipients so as to be prepared into oral medication dosage forms according to conventional methods. The Aleuritopteris argentea Fee extract can be used for preparing drugs for preventing and treating diabetes.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to a preparation method and application of an extract of Chinese medicinal materials, in particular to a preparation method of an extract of Tongjingcao and its application in the preparation of drugs for preventing and treating diabetes. Background technique [0002] With the aging of the world's population, diabetes has become a common and frequently-occurring disease, and its incidence is on the rise in industrialized countries. According to statistics, there are about 150 million diabetic patients in the world, 80% of which are non-insulin-dependent diabetes (type 2), of which there are about 30 million in my country. The number of deaths caused by diabetes complications ranks third after cardiovascular and cerebrovascular diseases and cancer in developed countries, which has attracted great attention from all over the world, and researches on the pathogenesis and drug prevention and tr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/11A61P3/10
Inventor 于莉王圣丽
Owner 王珊
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com