Preparation and application of a Dai medicine extract with hypoglycemic effect

A technology of extracts and pharmaceutical preparations, which is applied in the preparation and application of Dai medicine extracts with hypoglycemic effects, and can solve problems such as side effects of the digestive tract

Inactive Publication Date: 2016-05-11
张宁
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many contraindications and adverse reactions for diabetes treatment drugs. Long-term use may easily lead to liver toxicity and gastrointestinal side effects.

Method used

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  • Preparation and application of a Dai medicine extract with hypoglycemic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of embodiment 1 Dai medicine extract

[0023] (1) Take 20 parts of Dischidiaminor (Vahl.) Merr., 10 parts of Aspidopterys obcordata Hemsl., 20 parts of Passiflora wilsonii Hemsl., 10 parts of Clerodendrum japonicum (Thunb.) Sweet) parts, mixed and pulverized, and passed through a Pharmacopoeia No. 2 sieve.

[0024] (2) Take the medicinal material powder obtained in (1), add 30% ethanol with 10 times the weight of the medicinal material, heat and reflux for extraction, and the extraction frequency is 1 time.

[0025] (3) Take the medicinal solution extracted in (2), and concentrate it in a rotary evaporator, the temperature of the concentrated water bath does not exceed 60°C, and finally obtain an extract with a relative density of 1.15.

[0026] (4) Take the extract obtained in (3), add 5 times the mass of water to dilute it, mix it with an equal volume of gel, mix well, load the sample on the silica gel column, and the amount of the sample is the ratio...

Embodiment 2

[0029] The preparation of embodiment 2 Dai medicine extract

[0030] (1) Take 50 parts of Dischidiaminor (Vahl.) Merr., 30 parts of Aspidopterys obcordata Hemsl., 40 parts of Passiflora wilsonii Hemsl., 30 parts of Clerodendrum japonicum (Thunb.) Sweet) parts, mixed and pulverized, and passed through a Pharmacopoeia No. 2 sieve.

[0031] (2) Take the medicinal material powder obtained in (1), add 100% ethanol with 10 times the mass of the medicinal material, and perform ultrasonic extraction, and the number of extraction times is 3 times.

[0032] (3) Concentrate the liquid medicine extracted in (2) in a rotary evaporator, the temperature of the concentrated water bath shall not exceed 60°C, and finally obtain an extract with a relative density of 1.5.

[0033] (4) Take the extract obtained in (3), add 5 times the mass of water to dilute it, mix it with an equal volume of gel, mix well, load the sample on the silica gel column, and the amount of the sample is the ratio of the...

Embodiment 3

[0036] The preparation of embodiment 3 Dai medicine extract

[0037](1) Take 30 parts of Dischidiaminor (Vahl.) Merr., 20 parts of Aspidopterys obcordata Hemsl., 30 parts of Passiflora wilsonii Hemsl., 20 parts of Clerodendrum japonicum (Thunb.) Sweet) parts, mixed and pulverized, and passed through a Pharmacopoeia No. 2 sieve.

[0038] (2) Take the medicinal material powder obtained in (1), add 70% ethanol with 10 times the weight of the medicinal material, and perform ultrasonic extraction, and the extraction frequency is 2 times.

[0039] (3) Take the liquid medicine extracted in (2), and concentrate it in a rotary evaporator, the temperature of the concentrated water bath shall not exceed 60°C, and finally obtain an extract with a relative density of 1.28.

[0040] (4) Take the extract obtained in (3), add 5 times the mass of water to dilute it, mix it with an equal volume of gel, mix well, load the sample on the silica gel column, and the amount of the sample is the rati...

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Abstract

The invention discloses a Dai medicine extract with a hypoglycemic effect, preparation and application thereof. The Dai medicine extract is extracted from the Dai medicines Dischidia minor (Vahl.) Merr., Aspidopterys obcordata Hemsl., Passiflora wilsonii Hemsl., and Clerodendrum japonicum (Thunb.) Sweet. The invention also discloses a preparation method of the extract, and also discloses application of the extract and its medicinal composition as medicines and health care products, especially application in preparation of hypoglycemic medicines and health care products.

Description

technical field [0001] The present invention relates to a kind of extracting from Dai medicine hemp baa cloth (Dischidiaminor (Vahl.) Merr.), Hei Gai Guan (Aspidopterys obcordata Hemsl.), Ya Nanba (Passiflorawilsonii Hemsl.), Binliang (Clerodendrum japonicum (Thunb.) Sweet) An extract with significant hypoglycemic effect, a preparation method of the extract, a drug combination containing the extract, and the application of the extract and the drug combination as medicine and health care products, especially for hypoglycemic drugs and The preparation of health products belongs to the field of medicines and health products. Background technique [0002] Diabetes is a systemic chronic progressive disease. Because the islet cells cannot secrete insulin normally, the relative or absolute deficiency of insulin and the decrease of target cells’ sensitivity to insulin lead to the disorder of sugar, protein, fat, water and electrolyte metabolism, so that liver glycogen and muscle gl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/85A23L33/00A61P3/10
Inventor 王志刚周博董辉王佳天曲岩刘大旭雷双媛单军娜徐红丹李光赵冬旭耿放王发善张宁
Owner 张宁
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