Application of bryopsis plumose polysaccharide

A technology of feather algae polysaccharides and monosaccharides, which is applied in the application field of feather algae polysaccharides to achieve the effect of inhibiting excessive activation

Active Publication Date: 2014-03-05
南通中国科学院海洋研究所海洋科学与技术研究发展中心 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The research on feather algae mainly focuses on its chloroplast genes, protoplasts and tissue culture, but the rese

Method used

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  • Application of bryopsis plumose polysaccharide
  • Application of bryopsis plumose polysaccharide
  • Application of bryopsis plumose polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, moss feather algae ( Bryopsis hypnoides ) Preparation of polysaccharide (BF)

[0020] Take 50g of dried moss feather algae, use 2000mL of tap water to extract in a pressure cooker at 115°C for 3 hours, sieve and filter to separate the algal residue, filter with diatomaceous earth, filter the extract, concentrate the filtrate and put it into a dialysis machine with a molecular weight cut-off of 3500 Da Dialysis in the bag, tap water dialysis for 48 hours, distilled water dialysis for 24 hours, concentrated to a small volume and then freeze-dried to obtain the water-extracted feather algae polysaccharide sample (BF), with a yield of 0.75%.

[0021] The chemical composition analysis, monosaccharide ratio analysis, sulfate content and molecular weight determination results of BF are shown in Table 1. The results of the IR spectrum show that BF is a sulfated polysaccharide at 1242 cm -1 and 845 cm -1 The characteristic absorption peaks of sulfuric acid grou...

Embodiment 2

[0022] Embodiment 2, very large feather algae ( Bryopsis maxima ) Preparation of polysaccharide (MF)

[0023] Take 50g of dried Plumella maxima, use 2000mL of tap water to extract in a pressure cooker at 115°C for 3 hours, filter the algae residue through a sieve, filter with diatomaceous earth, filter the extract, concentrate the filtrate, and put it into a dialysis machine with a molecular weight cut-off of 3500 Da. Dialysis in the bag, tap water dialysis for 48 hours, distilled water dialysis for 24 hours, concentrated to a small volume and then freeze-dried to obtain the water-extracted feather algae polysaccharide sample (MF), with a yield of 1.33%.

[0024] The results of chemical composition analysis, monosaccharide ratio analysis, sulfate content and molecular weight determination of MF are shown in Table 1. The IR spectrum results show that MF is a sulfated polysaccharide at 1246 cm -1 and 843 cm -1 The characteristic absorption peaks of sulfuric acid groups appe...

Embodiment 3

[0025] Embodiment 3, Pseudomonas ( Bryopsis corticulans ) Preparation of polysaccharide (CF)

[0026] Take 50g of dry Pseudorhiza algae, use 2000mL of tap water to extract in a pressure cooker at 115°C for 3 hours, filter the algae residue through a sieve, filter with diatomaceous earth, filter the extract, concentrate the filtrate, and put it into a dialysis machine with a molecular weight cut-off of 3500 Da. Dialysis in the bag, tap water dialysis for 48 hours, distilled water dialysis for 24 hours, concentrated to a small volume and then freeze-dried to obtain the water-extracted feather algae polysaccharide sample (CF), with a yield of 2.33%.

[0027] The results of chemical composition analysis, monosaccharide ratio analysis, sulfate content and molecular weight determination of CF are shown in Table 1. The results of the IR spectrum show that CF is a sulfated polysaccharide at 1243 cm -1 and 844 cm -1 The characteristic absorption peaks of sulfuric acid groups appea...

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Abstract

The invention provides an application of bryopsis plumose polysaccharide in an anticomplementary medicament. The bryopsis plumose polysaccharide has the complementary activity; the application of the bryopsis plumose polysaccharide refers to an application of the bryopsis plumose polysaccharide with the complementary activity in preparation of an anticomplementary medicament or/and an anticomplementary health-care product. According to the application provided by the invention, the condition that the bryopsis plumose polysaccharide has a significant inhibiting effect on complementary activities of a classical pathway and an alternative pathway is found out for the first time. The invention discloses the application of the bryopsis plumose polysaccharide in preparation of the anticomplementary medicament and health-care product. Excessive activation of a complement system can be inhibited, so that the bryopsis plumose polysaccharide has certain prevention and treatment effects on a plurality of diseases such as systemic lupus erythematosus, rheumatoid arthritis and acute respiratory distress syndrome caused by excessive activation of the complement system.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a cucurbitan with complement activity. Background technique [0002] The complement system is one of the important immune defense systems of the human body, and plays an important role in physiological processes such as eliminating foreign microorganisms and maintaining the balance of the body. Inhibiting the excessive activation of the complement system has certain preventive and therapeutic effects on various diseases such as systemic lupus erythematosus, rheumatoid arthritis, and acute respiratory distress syndrome. At present, there is no ideal drug for the treatment of such diseases, so there is an urgent need for a new type of complement inhibitor with high efficiency, low toxicity and specificity in clinical practice. [0003] The ocean is the largest area on the earth, so the development of marine drugs is getting more and more attention, and the extr...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61P37/02A61P19/04A61P19/02A61P29/00A61P11/00A23L1/29A23L33/00
Inventor 王晶张全斌张虹牛锡珍
Owner 南通中国科学院海洋研究所海洋科学与技术研究发展中心
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