Method for reducing use amount of auxiliary materials for spray drying of traditional Chinese medicine extract

A technology of excipient dosage and extract, which is applied in the direction of pharmaceutical formulations, plant raw materials, medical preparations containing active ingredients, etc., can solve problems such as low glass transition temperature, reduce the proportion of excipients used, and easy precipitation, so as to improve vitrification Transition temperature, improved yield, and good reproducibility

Active Publication Date: 2015-06-17
河北省农林科学院经济作物研究所
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Maltodextrin and lactose are the most frequently used excipients in spray drying. Most traditional Chinese medicine extracts can be successfully spray-dried without adding excipients or adding a small amount of excipients, but the glass transition temperature of some extracts is relatively low. The applicant's research found that such as Polygonatum, Lycium barbarum, Codonopsis pilosula, Jujube, Rehmannia glutinosa, Polygonatum odoratum, Cornus, Melissa, Honey aster, Honey coltsfoot, Ophiopogon japonicus, Asparagus, Cistanche cistanche, Trichosanthes, Hawthorn, etc. Varieties are prone to hot-melt wall sticking phenomenon. After the water evaporates, the powder particles obtained from such extracts will soften or melt into paste after being heated in the drying tower, and adhere to the tower wall, which cannot be effectively collected, and the material absorbs moisture. very strong
At present, in industrial production, the method of increasing the amount of excipients is used to overcome the wall sticking phenomenon. In order to ensure the smooth progress of the spray drying process, the amount of excipients added is usually about 3 times or more than the solid content of the medicinal materials, but the proportion of excipients is too large, making the medicinal materials effective The ingredients are diluted, which increases the amount of clinical use, which does not meet the design principles of extracting and concentrating Chinese herbal medicines
Another report uses the combination of maltodextrin and β-cyclodextrin to improve the properties of materials and reduce the proportion of auxiliary materials. Methylcellulose, hydroxypropylcellulose and hypromellose are used, but this method cannot be used in comparison Reduce the proportion of excipients to a great extent, and β-cyclodextrin, methyl cellulose, hydroxypropyl cellulose, and hypromellose have low solubility in water and are easy to precipitate, which affects the progress of spray drying.

Method used

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  • Method for reducing use amount of auxiliary materials for spray drying of traditional Chinese medicine extract
  • Method for reducing use amount of auxiliary materials for spray drying of traditional Chinese medicine extract
  • Method for reducing use amount of auxiliary materials for spray drying of traditional Chinese medicine extract

Examples

Experimental program
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Effect test

Embodiment 1

[0018] Preparation of spray-dried powder of Lycium barbarum extract. Take 10kg of wolfberry decoction pieces, add water to extract twice, add 8 times of water for the first time, decoct for 2 hours, add 7 times of water for the second time, decoct for 1 hour, combine the decoction, concentrate under reduced pressure to 1.07-1.09, pass 180 mesh sieve to obtain extract. The auxiliary materials are added to the extract to carry out spray drying, and the spray drying conditions are that the air inlet temperature is 160°C-175°C, and the outlet air temperature is 90°C-95°C. The experiment is divided into group A and group B, (1) group A, add sodium chloride 0.4kg (about 20% of the solid content), stir and dissolve, and spray dry; (2) group B, add sodium chloride 0.6 kg (about 30% of the solid content), stir to dissolve, and then spray dry; (3) Group C, add 0.8kg of sodium chloride (about 40% of the solid content), stir to dissolve, and spray dry.

[0019] The experimental results ...

Embodiment 2

[0023] Preparation of spray-dried powder of Lycium barbarum extract. Take 10kg of wolfberry decoction pieces, add water to extract twice, add 8 times of water for the first time, decoct for 2 hours, add 7 times of water for the second time, decoct for 1 hour, combine the decoction, concentrate under reduced pressure to 1.07-1.09, pass 180 mesh sieve to obtain extract. Add auxiliary material in extractum and carry out spray-drying, and spray-drying condition is the same as embodiment 1. The experiment is divided into 4 groups A, B, C, and D. (1) Group A, add 0.4kg of sodium chloride (about 20% of the solid content), stir and dissolve, and spray dry; (2) Group B, Add 0.4kg of sodium chloride (about 20% of the solid content), add 1.6kg of maltodextrin (about 80% of the solid content), stir and dissolve, and spray dry; (3) Group C, add maltodextrin Add 2.0kg of maltodextrin (about 100% of the solid content), stir to dissolve, and spray dry; (4) Group D, add 7kg of maltodextrin (...

Embodiment 3

[0028] Preparation of spray-dried powder of Polygonatum extract. Take 10kg of sealwort decoction pieces, add water to extract twice, add 8 times of water for the first time, decoct for 1.5 hours, add 7 times of water for the second time, decoct for 1 hour, combine the decoction, concentrate under reduced pressure to 1.07-1.09, pass 180 Mesh sieve to obtain extract.

[0029]Add auxiliary materials to the extract for spray drying, set the inlet air temperature at 170°C-180°C, and the outlet air temperature at 90°C-105°C. The experiment is divided into 5 groups: A, B, C, D, and E, (1) Group A , add 0.4kg of sodium chloride (about 20% of the solid content), stir to dissolve, and spray dry; (2) Group B, add 0.4kg of sodium chloride (about 20% of the solid content), add malt Dextrin 1.6kg (about 80% of the solid content), stirred and dissolved, and spray dried; (3) Group C, add maltodextrin 2.0kg (about 100% of the solid content), stirred and dissolved, and spray Drying; (4) Group...

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Abstract

The invention belongs to spray drying of traditional Chinese medicine, and particularly relates to a method for reducing the use amount of auxiliary materials for spray drying of a traditional Chinese medicine extract. The method comprises the steps of condensing the traditional Chinese medicine extract, filtering to form an extracting solution, adding sodium chloride accounting for 1-100% by mass of a solid content of the extracting solution, and performing the spray drying after dissolving. The method solves the technical problems of excessive addition of the auxiliary materials in a spray drying process and the like in the prior art. The method has the advantages that the glass transition temperature of a part of traditional Chinese medicine can be effectively increased, the yield of a spray drying technology is increased, attachments on a tower wall of a drying tower fall easily after vibrating, and a product is delicate in taste and the like.

Description

technical field [0001] The invention belongs to spray drying of traditional Chinese medicine, in particular to a method for reducing the amount of spray drying auxiliary materials of Chinese medicine extracts. Background technique [0002] Spray drying has the advantages of short drying time, high efficiency, simple and controllable process, low water content of the product, and good resolubility. It is widely used in the industry and is a common drying method in industrial production. However, the problem of sticking to the wall is often encountered during the spray drying operation, which affects the yield of the product and wastes raw materials, and severe sticking to the wall will make the drying process impossible. The main causes of wall sticking include: (1) The moisture content of the material is too high, the material is viscous, and it adheres to the inner wall of the drying tower; (2) The glass transition temperature of the material is too low, the dried material...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K47/02A61K47/36A61K47/26A61K36/815A61K36/8969A61K36/725A61K36/344A61K36/428A61K36/734A61K36/69A61K36/195A61K36/315
Inventor贾东升谢晓亮温春秀刘灵娣刘铭刘金娜田伟
Owner河北省农林科学院经济作物研究所