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Effective part of cheezheng pain relieving plaster and preparation method therefor

A technology of effective parts and Xiaotong plaster, which is applied in the direction of medical preparations containing active ingredients, non-central analgesics, plant raw materials, etc., can solve the problems of affecting the curative effect, prolonging the course of the disease, and inconvenience to doctors and patients, and achieve the goal of overcoming the morbidity. The effect of allergy side effects

Inactive Publication Date: 2014-03-19
ZHEJIANG FORESTRY UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the plaster has certain adverse reactions, mainly manifested as acute and delayed drug-induced rashes and local allergies, resulting in skin rashes, itching, bullae, ulceration and other symptoms, often having to interrupt the treatment, thus affecting the quality of life. curative effect, prolonged the course of the disease, and brought inconvenience to doctors and patients

Method used

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  • Effective part of cheezheng pain relieving plaster and preparation method therefor
  • Effective part of cheezheng pain relieving plaster and preparation method therefor
  • Effective part of cheezheng pain relieving plaster and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0152] Embodiment 1: The preparation method of effective part of the present invention

[0153] Take the semi-finished raw material powder of the preparation Qizheng Xiaotong plaster, and use supercritical CO 2 Extraction process, its parameters are, the extraction pressure is 20MPa, the extraction temperature is 45°C, and the extraction time is 2h, other conditions are determined as follows: the pressure of the separation kettle 1 and the separation kettle 1I are both set to 5.0MPa, and the temperature is 45°C; 2 The flow rate is 20L / h. The extract obtained under these conditions is the effective part of Qizheng Xiaotong Plaster.

[0154] Take the above effective parts, and carry out the determination of the characteristic chemical composition according to the method of Experimental Example 3. As a result, the above extracts can simultaneously detect 9 chemical components consistent with Experimental Example 3, all containing phenylethyl alcohol, phenylpyruvate, Characteris...

Embodiment 2

[0155] Embodiment 2: The preparation method of effective part of the present invention

[0156] The raw materials and medicinal materials of Qizhengxiaotong paste: 15 parts of Duyiwei, 10 parts of Oxytropis, 60 parts of turmeric, 20 parts of Zanthoxylum bungeanum, 15 parts of buffalo horn, 40 parts of water cypress branch, mixed, crushed, processed 100 mesh sieve. Using supercritical CO 2 The parameters of the extraction process are as follows: the extraction pressure is 20MPa, the extraction temperature is 45°C, and the extraction time is 2h. Other conditions are determined as follows: the pressure of the separation tank I and the separation tank II are both set at 5.0MPa, and the temperature is 45°C; 2 The flow rate is 20L / h. The extract obtained under these conditions is the effective part of Qizheng Xiaotong Plaster.

[0157] Take the above effective parts, and carry out the determination of the characteristic chemical composition according to the method of Experimental...

Embodiment 3

[0158] Embodiment 3: The preparation method of the effective part of the present invention

[0159] Take the raw material powder of the semi-finished product of the preparation Qizheng Xiaotong Plaster, add 9 times the volume of chloroform of the powder mass, reflux extraction twice, each time for 3 hours, take the juice and remove the residue, combine, filter, and concentrate under reduced pressure to a specific gravity of 1.2. The extract of Deqizhengxiaotong plaster is the effective part of Qizhengxiaotong plaster.

[0160] The above effective parts were taken, and the characteristic chemical composition was measured according to the method of Experimental Example 3. As a result, the above extracts could detect 9 chemical components consistent with Experimental Example 3 at the same time. Characteristic components of alkene, 1,4-dimethyl-2,5-diisopropylbenzene, atractyl alcohol, eucalyptol, heptadecane, 2,6,10-trimethyl-dodecane, eicosane .

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Abstract

The invention discloses an effective part of a cheezheng pain relieving plaster, a preparation method therefor and characteristic chemical composition. Efficacy of an external preparation prepared from the effective part is better than that of an original preparation. Adverse effects of existing preparations are overcome, namely, the effective part has no sensitization side effects. The effective part contains the following 9 kinds of chemical ingredients at the same time, and the chemical ingredients are phenethyl alcohol, phenylpyruvic acid, calamenene, 1,4-dimethyl-2,5-diisopropyl benzene, atractylol, eudesmol, heptadecane, 2,6,10-trimethyl dodecane and eicosane. The effective part can be prepared into external preparations of an ointment, an emplastrum, a poultice, a spray, a liniment and the like with supplement of pharmaceutically common auxiliary materials.

Description

technical field [0001] The invention relates to an effective part of a traditional Chinese medicine, which specifically belongs to the effective part of a traditional Chinese medicine compound Qizheng Xiaotong plaster and an extraction method thereof, and is used for overcoming adverse reactions of existing preparations and enhancing efficacy. technical background [0002] Qizheng Xiaotong Plaster is developed based on the original patent CN100427062C. It has the functions of promoting blood circulation, removing stasis, reducing swelling and relieving pain. Topical preparations for old injuries. It is easy to apply and reliable in curative effect, and has been favored by clinicians and patients. However, the plaster has certain adverse reactions, mainly manifested as acute and delayed drug-induced rashes and local allergies, resulting in skin rashes, itching, bullae, ulceration and other symptoms, often having to interrupt the treatment, thus affecting the quality of life....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/70A61P29/00A61P19/02A61P19/00A61P21/00A61K35/32
Inventor 田薇
Owner ZHEJIANG FORESTRY UNIVERSITY
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