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Preparation method of fukean tablet and application of fukean tablet in preparation of drugs for inhibition of cell proliferation of mouse embryonic carcinoma cell P19

A technology of Fukean tablets and Jiubingying, which is applied in the preparation of drugs for inhibiting the proliferation of mouse teratoma cell P19 cells. In the field of preparation of Fukean tablets, it can solve the problem of large dosage, backwardness, and many impurities in patients. problem, achieve the effect of reducing dosage

Active Publication Date: 2014-03-26
北京缘顺福咨询有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report about using microwave technology and macroporous resin adsorption extraction technology in the extraction and preparation of Fukean Tablets. However, the boiling and alcohol extraction has a rough and backward process and many impurities, which leads to excessive dosage for patients and is inconvenient. Taking it seriously affects the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take 1000g of twig vine, 1000g of fire charcoal mother, 670g of jiubing, 330g of plantain, and 330g of pomegranate peel, add 10L of 65% ethanol, put it into a microwave extraction device for microwave extraction, extraction power 700W, extraction 2 times, each time For 8 minutes, the extracts were combined, concentrated, added to a Diaion HP-10 macroporous adsorption resin column, eluted with 65% ethanol, collected 5 times the column volume eluate, recovered ethanol under reduced pressure, concentrated and dried to obtain microwave extraction The product is mixed with microwave extract and added with starch and 70% ethanol to make granules, dried and pressed into tablets to make 500 tablets, each weighing 0.3g.

[0024] After testing, the content of total flavonoids in the finished product is 98.92mg / tablet based on rutin

Embodiment 2

[0026] Take 1000g of twisted vine, 1000g of fire charcoal mother, 670g of jiubing, 330g of plantain, and 330g of pomegranate peel, crush the five flavors of medicinal materials, add 10L of 65% ethanol, and put them into a microwave extraction device for microwave extraction. The extraction power is 600W. Extract 2 times, 5 minutes each time, combine the extracts, concentrate, add to Diaion HP-10 macroporous adsorption resin column, elute with 65% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate And dry to get the microwave extract, mix the microwave extract with starch and 70% ethanol to make granules, dry, compress into tablets, and make 500 pieces, each weighing 0.3g.

[0027] After testing, the content of total flavonoids in the finished product is 82.16 mg / tablet in terms of rutin.

Embodiment 3

[0029] Take 1000g of twisted vine, 1000g of fire charcoal mother, 670g of jiubing, 330g of plantain, and 330g of pomegranate peel, crush the five herbs, add 10L of 65% ethanol, put them into the microwave extraction device for microwave extraction, and put them into the microwave extraction device Microwave extraction was carried out in the medium, the extraction power was 800W, and the extraction was performed twice, 10 minutes each time, the extracts were combined, concentrated, added to the DiaionHP-10 macroporous adsorption resin column, eluted with 65% ethanol, and collected 5 times the column volume for elution Liquid, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract, mix microwave extract with starch, 70% ethanol to make granules, dry, compress into tablets, and make 500 tablets, each weighing 0.3g.

[0030] After testing, the content of total flavonoids in the finished product is 90.44mg / tablet in terms of rutin.

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a preparation method and application of a fukean tablet. The preparation method of the fukean tablet is as follows: the fukean tablet is prepared from 1000 g of jasminum elongatum, 1000 g of Chinese knotweed, 670 g of ovate leaf holly bark, 330 g of plantain herb and 330 g of pomegranate peel as raw materials by use of microwave extraction and macroporous resin adsorption, and the total flavonoid content is greatly improved. The invention also provides application of the fukean tablet in preparation of drugs for inhibition of cell proliferation of mouse embryonic carcinoma cell P19.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Fukean tablet and its application in the preparation of a medicine for inhibiting the proliferation of mouse teratoma cell P19 cells. Background technique [0002] The standard number of Fukean Tablets is WS-10256 (ZD-0256)-2002, which is recorded in the Spleen and Stomach Subvolume of the National Compilation of Chinese Patent Medicine Standards. It is made from 1000g of twisting vine, 1000g of Huotanmu, 670g of jiubing, 330g of plantain, and 330g of pomegranate peel. For acute gastroenteritis, abdominal pain, diarrhea, and vomiting caused by indigestion. [0003] In the prior art, there is no report about using microwave technology and macroporous resin adsorption extraction technology in the extraction and preparation of Fukean Tablets. However, the boiling and alcohol extraction has a rough and backward process and ma...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/20A61P1/00A61P1/08A61P1/12A61P35/00
Inventor 魏书同段学文
Owner 北京缘顺福咨询有限公司
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