Pyruvic acid medicinal composition and application thereof in preparation of medicament for treating chronic obstructive pulmonary diseases

A chronic obstructive, pyruvic acid technology, applied in the medical field, can solve the problems of toxic side effects and adverse reactions, and achieve the effect of comprehensive effect, better effect and high water solubility

Inactive Publication Date: 2014-04-16
JIANG SU PHARMAMAXCORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the treatment of chronic obstructive pulmonary disease is mainly through β2 receptor blockers, corticosteroids and antibiotics alone or in combination. These drugs often lead to many complications due to their severe side effects and adverse reactions.
This is the main shortcoming in the current treatment of COPD

Method used

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  • Pyruvic acid medicinal composition and application thereof in preparation of medicament for treating chronic obstructive pulmonary diseases
  • Pyruvic acid medicinal composition and application thereof in preparation of medicament for treating chronic obstructive pulmonary diseases
  • Pyruvic acid medicinal composition and application thereof in preparation of medicament for treating chronic obstructive pulmonary diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Preparation of 0.5mMol / l sodium pyruvate inhalation (1000 pieces)

[0054] prescription

[0055]

[0056] Process: add the prescribed amount of sodium pyruvate and sodium chloride to 95% of the remaining purified water and stir well, then add 5% of the remaining purified water and stir evenly. After aseptic filtration, carry out aseptic filling, sub-package to obtain 0.5mMol / l sodium pyruvate inhalation.

[0057]Through clinical research, this product has a good curative effect on the treatment of mild chronic obstructive pulmonary disease.

Embodiment 2

[0059] Preparation of 1.0mMol / l sodium pyruvate inhalation (1000 pieces)

[0060] prescription

[0061]

[0062] Process: add the prescribed amount of sodium pyruvate and sodium chloride to 95% of the remaining purified water and stir well, then add 5% of the remaining purified water and stir evenly. After aseptic filtration, carry out aseptic filling, sub-package to obtain 1.0mMol / l sodium pyruvate inhalation.

[0063] Through clinical research, this product has a good curative effect on the treatment of mild chronic obstructive pulmonary disease.

Embodiment 3

[0065] Preparation of 1.5mMol / l sodium pyruvate inhalation (1000 pieces)

[0066] prescription

[0067]

[0068]

[0069] Process: add the prescribed amount of sodium pyruvate and sodium chloride to 95% of the remaining purified water and stir well, then add 5% of the remaining purified water and stir evenly. Carry out aseptic filling after aseptic filtration, sub-pack the existing 1.5mMol / l sodium pyruvate inhalation.

[0070] Through clinical research, this product has a good curative effect on the treatment of mild chronic obstructive pulmonary disease.

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PUM

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Abstract

The invention provides an inhalant composition for treating chronic obstructive pulmonary diseases. Active ingredients in the composition include pyruvic acid, medicinal pyruvate, a pyruvic acid medicinal precursor or a composition thereof. The chronic obstructive pulmonary diseases include chronic bronchitis and emphysema. Compared with the prior art, the inhalant composition used for treating chronic obstructive pulmonary diseases has the advantages that 1, the inhalant can directly enter the lung in a highly targeting manner, can directly act on the focus of the lung in a highly targeting manner, and does not participate in body metabolism; 2, the medicinal pyruvate, the pyruvic acid precursor and the pyruvic acid in the composition are nutrient substances, and are abundant in the blood, so that the toxic and side effects are reduced, and higher safety and medicament stability are achieved; 3, as an antioxidant, sodium pyruvate differs from antibiotics, expectorants and sterol medicaments, acts more comprehensively, and is better in effect.

Description

technical field [0001] The invention provides the application of pyruvic acid, its medicinal salt and medicinal precursor in the preparation of medicine for treating chronic obstructive pulmonary disease. The invention belongs to the field of medical technology. The present invention also includes methods of making and using optimized pyruvate pharmaceutical compositions for medical efficacy. Background technique [0002] Chronic obstructive pulmonary disease, also known as obstructive emphysema, is the expansion of the distal part of the terminal bronchioles (including respiratory bronchioles, alveolar ducts, alveolar sacs, and alveoli) with destruction of the air cavity walls. And often accompanied by gastric ulcer, respiratory failure, spontaneous pneumothorax, sleep-disordered breathing, chronic cor pulmonale and right heart failure. In recent decades, the incidence of obstructive emphysema has increased significantly. This is due to air pollution, smoking, and chronic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/19A61K31/7052A61K31/198A61K31/5375A61K31/337A61K9/72A61P11/00A61P11/06A61K31/137
CPCA61K31/19A61P11/00A61P11/06A61P39/02
Inventor 蒋志君阿兰·马丁蒋罗茵黄小棠陈幸幸郭靖陆小娟
Owner JIANG SU PHARMAMAXCORP
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