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A kind of compound soft capsule of sea cucumber intestinal extract and preparation method thereof

A compound soft capsule and American ginseng extract technology, which is applied in capsule delivery, drug combination, and pharmaceutical formula, can solve the problems of low efficiency, incomplete removal, and single ingredient of sea cucumber intestines, so as to achieve easy digestion and absorption , The preparation method is reasonable and the composition is scientific.

Active Publication Date: 2017-11-10
SHANDONG HOMEY AQUATIC DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the shortcomings of single ingredients, low efficacy, low efficiency and incomplete removal of sea cucumber sausage artificially in sea cucumber sausage products given in the prior art, the present invention provides a sea cucumber sausage extract compound soft capsule and its preparation The method, the preparation method has reasonable technology, scientific ingredients, simple operation, strong operability, and is easy to realize industrial production; the compound soft capsule of sea cucumber sausage extract prepared by this method has anti-fatigue, anti-aging, hypolipidemic, anti-tumor, and beneficial effects. Skin beauty, enhance immunity and other effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A preparation method of sea cucumber intestinal extract compound soft capsule, through the following process steps:

[0033] a, preparation of sea cucumber rice rolls

[0034] a1. Pretreatment of sea cucumber sausages: select fresh sea cucumber sausages as raw materials, place them in a colloid mill, add water 8 times the weight of sea cucumber sausages, and grind to obtain sea cucumber sausage pulp;

[0035] a2. Enzymolysis Put the obtained sea cucumber intestine pulp into an enzymolysis container, heat it to 95°C and keep it for 25 minutes to denature the protein; then cool it to 55°C, adjust the pH value to 7, add neutral protease and flavor enzyme double enzyme , enzymatic hydrolysis for 4 hours; wherein, the enzyme activity ratio of neutral protease and flavor enzyme is 1:1.5, and the total enzyme dosage of neutral protease and flavor enzyme is 2000u / g sea cucumber sausage; after enzymolysis is completed, heat to 95°C to inactivate 25min, to obtain sea cucumber inte...

Embodiment 2

[0052] A preparation method of sea cucumber intestinal extract compound soft capsule, through the following process steps:

[0053] a, preparation of sea cucumber rice rolls

[0054] a1. Pretreatment of sea cucumber sausages: select fresh sea cucumber sausages as raw materials, place them in a colloid mill, add water 10 times the weight of sea cucumber sausages, and perform grinding treatment to obtain sea cucumber sausage pulp;

[0055] a2. Enzymolysis Put the obtained sea cucumber intestine pulp into an enzymolysis container, heat to 100°C and keep for 20 minutes to denature the protein; then cool to 60°C, adjust the pH value to 8, add neutral protease and flavor enzyme double enzyme , enzymatic hydrolysis for 3 hours; wherein, the enzyme activity ratio of neutral protease and flavor enzyme is 1:2, and the total enzyme dosage of neutral protease and flavor enzyme is 1500u / g sea cucumber sausage; after enzymolysis is completed, heat to 100°C to inactivate the enzyme 20min to...

Embodiment 3

[0072] A preparation method of sea cucumber intestinal extract compound soft capsule, through the following process steps:

[0073] a, preparation of sea cucumber rice rolls

[0074] a1. Pretreatment of sea cucumber sausages: select fresh sea cucumber sausages as raw materials, place them in a colloid mill, add water 5 times the weight of sea cucumber sausages, and grind to obtain sea cucumber sausage slurry;

[0075] a2. Enzymolysis Put the obtained sea cucumber intestine pulp into an enzymolysis container, heat to 90°C, keep for 30 minutes to denature the protein; then cool to 50°C, adjust the pH value to 6, add neutral protease and flavor enzyme double enzyme , enzymatic hydrolysis for 5 hours; wherein, the enzyme activity ratio of neutral protease and flavor enzyme is 1:1, and the total enzyme dosage of neutral protease and flavor enzyme is 1500u / g sea cucumber sausage; after enzymolysis is completed, heat to 90°C to inactivate the enzyme 30min, to obtain sea cucumber int...

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Abstract

The invention relates to a compound soft capsule of sea cucumber sausage extract and a preparation method thereof. The sea cucumber sausage produced by fresh sea cucumber processing is used as a raw material, refined, heated and cooled, and neutral protease and flavor enzyme double enzymes are added to control the enzyme. Carry out enzymatic hydrolysis; the enzymatic hydrolysis solution is subjected to secondary centrifugation, and the collected supernatant is desalted by nanofiltration separation technology, and the obtained sea cucumber intestine liquid is dried to obtain sea cucumber intestine powder; sea cucumber intestine powder and traditional Chinese medicine extracts: wolfberry extract, astragalus membranaceus extract, American ginseng extract, Luo Han Guo extract, rhodiola rosea extract, yam extract and auxiliary materials soybean oil and beeswax to obtain sea cucumber sausage extract compound soft capsules. The preparation method of the invention has reasonable technology and strong operability. The prepared sea cucumber intestinal extract compound soft capsule has scientific components and reasonable matching, and has the effects of anti-fatigue, anti-aging, lowering blood fat, anti-tumor, beautifying skin and improving immunity.

Description

technical field [0001] The invention relates to a pharmaceutical preparation characterized by capsule preparations, in particular to a compound soft capsule of sea cucumber sausage extract and a preparation method thereof. Background technique [0002] Sea cucumber is one of the precious seafood. It contains more than 50 kinds of nutrients that are beneficial to human physiological activities. Among them, the protein content is high, and the trace elements are rich in types. It also has the functions of anticoagulation, antitumor, antibacterial, antiviral and improving immunity. In recent years, there have been more and more enterprises processing sea cucumbers. The leftovers in the processing of sea cucumbers—the sea cucumber intestines contain nutrients that are no less than those in the body wall. The vanadium content of its dry sausage is 12 parts per million, about 3 times higher than that of its body. It has the effect of warming the middle, tonifying deficiency and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8945A61K9/48A61P39/00A61P39/06A61P3/06A61P35/00A61P37/04A61K35/616
Inventor 袁文鹏刘昌衡孙永军史亚萍齐君乔若瑾黄婕胡炜贾爱荣刘新夏雪奎鞠文明唐晓波毕春雨
Owner SHANDONG HOMEY AQUATIC DEV
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