A kind of method for preparing midanaxin

A midanaxine and route technology, applied in the field of preparation of midanaxine, can solve the problems of low safety, unfriendly human body and environment, blindness, etc., and achieve the effect of being friendly to human body and environment
CN103772286BActive Publication Date: 2016-01-13JIANGZI QINGFENG PHARMACEUTICALS INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGZI QINGFENG PHARMACEUTICALS INC
Publication Date
2016-01-13

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Abstract

The invention discloses a method for preparing imidafenacin. The method comprises the steps of hydrolyzing 4-bromo-2,2-diphenyl butyronitrile into acid amide under an alkaline condition, and then enabling the acid amide to react with 2-methylimidazole so as to obtain a target product. The preparation method provided by the invention is high in yield, economical, simple, convenient, friendly to human body and environment, and suitable for industrialized large-scale production.
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Description

technical field

[0001] The invention belongs to the field of drug synthesis, and in particular relates to a new method for preparing midanacin. Background technique

[0002] Overactive bladder syndrome (symptomatic overactive bladder, OAB) is a common chronic lower urinary tract dysfunction, the International Anti-Urinary Incontinence Society (ICS) defined it as a urinary urgency (a strong sense of urination), frequency and urgent A syndrome characterized by sexual urinary incontinence.

[0003] The incidence rate of OAB is relatively high. The incidence rate of men over 75 years old in European and American countries is as high as 42%, and the incidence rate of women is slightly lower at 31%. The incidence rate of men over 50 years old in Beijing in China is as high as 16.4%. The overall incidence of incontinence and urge incontinence is 40.4%, which seriously affects the physical and mental health of patients and reduces the quality of life. There is no specific treatmen...

Claims

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