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Film-forming composition, and use thereof for treating herpes

A composition and film-forming technology, which is applied in the treatment of skin damage and herpes, can solve the problems of preventing herpes bacteria from forming, and achieve the effect of preventing bacterial invasion and avoiding repeated infection

Active Publication Date: 2014-05-14
URGO RECH INNOVATION & DEVEMENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the compositions proposed in these documents form films that do not form an effective barrier against the multiplication of herpes bacteria

Method used

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  • Film-forming composition, and use thereof for treating herpes
  • Film-forming composition, and use thereof for treating herpes
  • Film-forming composition, and use thereof for treating herpes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1: the preparation of composition A

[0095] The following method prepares composition A of the present invention

[0096] Element

[0097] Add castor oil, boric acid and citric acid to the water / ethanol mixture and stir for 10 minutes. Ethylcellulose was then dispersed into the mixture. Composition A was obtained after stirring the mixture for 30 minutes.

Embodiment 2

[0098] Example 2: Evaluation of the permeability of the membranes formed by composition A to infectious substances

[0099] 1. Materials:

[0100] The cells used were Vero cells from ATCC CCL-81 or the Medical Virology Laboratory of Institut Pasteur (Yasumunra Y. et al., 1962). These cells came from the kidneys of African green monkeys.

[0101] The culture and titration medium was DMEM medium ("Dulbecco / Vogt modified Eagle's minimal medium") supplemented with 2% glutamate, 4% FCS and 1% gentamicin sulfate.

[0102] The dilution medium is DMEM supplemented with 2% glutamate or 1% gentamicin sulfate.

[0103] The virus used was pseudorabies virus (PRV) (Aujesky disease virus): ATCC VR-135 (Aujesky A., 1902; Roiznan R. et al., 1981).

[0104] PRV belongs to the family Herpesviridae, the subfamily Alphaherpesvirinae, and the genus Varicellovirus

[0105] This virus is used as a model of human herpes type 1.

[0106] Plates and inserts used were from the supplier Dutscher. T...

Embodiment 3

[0152] Example 3: Comparative experiment of breaking strength of films formed from the composition of the invention (composition A of Example 1) and from comparative compositions (compositions B and C) not containing boric acid.

[0153] Composition B (no boric acid) consists of:

[0154] Element

weight%

[0155] Ethyl cellulose

10

castor oil

10

citric acid

0.5

ethanol

67.5

Deionized water

12

[0156] Add castor oil and citric acid to the water / ethanol mixture and stir for 10 minutes. Ethylcellulose was then dispersed in the mixture. Composition B was obtained after stirring the mixture for 30 minutes.

[0157] Preparation of Composition C (without boric acid and citric acid):

[0158] Element

weight%

Ethyl cellulose

10

castor oil

10

ethanol

68

Deionized water

12

[0159] Add castor oil to the water / ethanol mixture and...

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Abstract

The present invention relates to a topical film-forming composition including, in a pharmaceutically acceptable medium: 5 to 30 wt % of ethyl cellulose; 0.1 to 10 wt % of an auxiliary film-forming agent; 0.1 to 20 wt % of one or more triacids, at least one of which is boric acid; and 60 to 95 wt % of an organic solvent, the percentages being expressed by weight relative to the total weight of the composition. The invention also relates to the use of such a composition in a method for treating herpes, in particular herpes labialis.

Description

technical field [0001] The subject of the present invention is a film-forming composition based on ethylcellulose, which can form a protective film on the skin or mucous membranes, the subject of the invention is also its use for the treatment of skin lesions, especially herpes. Background technique [0002] The herpes virus (herpes simplex virus or HSV) is present in most of the human population. Although most of the time the infection is asymptomatic, it can cause skin lesions in the form of eruptive vesicular eruptions, especially at the mucous membrane level. The onset begins with simple itching and a red appearance, leading to the development of papules within hours. As they mature, papules become blisters and then vesicles containing clear fluid. The vesicles eventually burst to release fluid, and at this stage the risk of viral transmission and reproduction is extremely high. The vesicle then leaves a wound, which scabs over before healing. In addition, the later ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/10A61K47/12A61K47/38A61K47/44A61P31/22A61K9/00A61K9/70A61K47/02
CPCA61K9/0014A61K9/7015A61K47/38A61P31/22A61K9/70A61K47/44A61K31/365A61K47/10A61K47/42A61L26/0023
Inventor N·德兰
Owner URGO RECH INNOVATION & DEVEMENT
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