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Ilicis cornutae folium formula granule, preparation method and detection method thereof

A technology of formula granules and wolfberry leaves, which is used in pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc.

Active Publication Date: 2014-05-21
广东省中医药工程技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the quality control of wolfberry leaf formula granules using infrared spectroscopy

Method used

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  • Ilicis cornutae folium formula granule, preparation method and detection method thereof
  • Ilicis cornutae folium formula granule, preparation method and detection method thereof
  • Ilicis cornutae folium formula granule, preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation method of the wolfberry leaf formula granules of this embodiment is as follows:

[0053] (1) Take the raw citron leaves, add 12 times the weight of water of the raw citron leaves, soak for 1.5 hours, extract for 3 hours, heat and boil, keep it slightly boiling, heat and decoct for 2 hours, and filter the extract; the second time Add 10 times the amount of water, heat and cook for 1.5h, filter, and combine the extracts.

[0054] (2) Pump into the concentrator, control the concentration temperature between 50 and 80 ℃, and concentrate to a relative density of 1.12 to obtain the "Goji Ye Qing Gao". Take the "Zhu Gu Ye Qing Gao" while it is hot and place it in the ingredient tank. Heat to no less than 40°C, spray dry, control the inlet air temperature to 185°C, the outlet air temperature to 95°C, the negative pressure in the tower -0.03~-0.06Mpa, and the spray-dried powder is collected 8.9kg;

[0055] (3) Add 1.1kg of maltodextrin, mix well, and dry granulation (t...

Embodiment 2

[0061] The preparation method of the wolfberry leaf formula granules of this embodiment is as follows:

[0062] (1) Take 90 kg of raw citron leaves, add 10 times the weight of water of raw citron leaves, heat and boil, keep slightly boiling, heat and cook for 3 hours, and filter the extract; add 8 times the amount of the material for the second time Heat water, cook for 1h, filter, and combine the extracts;

[0063] (2) Pump into the concentrator, control the concentration temperature between 50 and 80 ℃, and concentrate to a relative density of 1.24 to obtain "Mutton Bone Leaf Clearing Ointment". Take the "Long Bone Leaf Clearing Ointment" while it is hot and place it in a vacuum drying oven. , Control the temperature at 60~75℃ (slowly increase temperature), the vacuum degree is -0.07~-0.085Mpa, and 9.2kg of dried citron leaf extract is collected;

[0064] (3) Crush, add 0.8kg of maltodextrin, mix well, and dry granulation (the diameter of the punching plate is between 1.30~1.70mm,...

Embodiment 3

[0073] The preparation method of the wolfberry leaf formula granules of this embodiment is as follows:

[0074] (1) Take 90kg of raw citron leaves, add 8 parts by weight of water of raw citron leaves, heat and boil, keep slightly boiling, heat and decoct for 2h, and filter the extract; add 6 times the amount of the material for the second time Heat water, decoct for 1.5h, filter, and combine the extracts;

[0075] (2) Pump into the concentrator, control the concentration temperature between 50 and 80 ℃, and concentrate to a relative density of 1.13 to obtain the "Molium Leaf Clearing Ointment". Take the "Molium Leaf Clearing Ointment" while it is hot and place it in the ingredient tank. Heat to not less than 40℃, spray dry, control the inlet air temperature to 175°C, the outlet air temperature to 85°C, the negative pressure in the tower -0.03~-0.06Mpa, and the spray dry powder is collected 8.3kg;

[0076] (3) Add 1.7kg of maltodextrin, mix well, and dry granulation (perforated plate...

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Abstract

The invention discloses an ilicis cornutae folium formula granule, a preparation method and a detection method thereof. The formula granule is prepared in the following steps: preparing an ilicis cornutae folium dried powder by using ilicis cornutae folium as a raw material through water extraction, compression in reduced pressure, drying and other process flows, and performing dry-method granulation directly by ilicis cornutae folium dried powder or mixing with a proper amount of auxiliaries. A gram of ilicis cornutae folium formula granule is equivalent to 9g of a raw drug, and ilicis cornutae folium decoction pieces and ilicis cornutae folium formula granule are subjected to quality detection by adopting infrared fingerprint spectrum. The ilicis cornutae folium has a complete and advanced production process and a controllable detection standard with strong specific, the advanced process can be realized, and the quality standard relates to a scientific, advanced and quick detection method which is strong in operability.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine formula granule and a preparation method and a detection method thereof, in particular to a Chinese medicine formula granule and a preparation method and a detection method thereof. Background technique [0002] Traditional Chinese medicine formula granules are processed through various techniques of Chinese herbal medicine under the guidance of TCM theories, and are used in the preparation of clinical TCM prescription granules; clinical applications and pharmacological experiments show that single Chinese medicine formula granules and traditional water decoction The medicine has basically the same curative effect and pharmacological effects, and the traditional Chinese medicine formula granules have the advantages of small volume, easy to carry and store, stable and controllable quality. As a new type of decoction to replace traditional Chinese medicine decoction pieces, it has the characteristics of ...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61P9/12G01N21/3563G01N30/02
Inventor 涂瑶生孙冬梅王洛临施之琪李智勇徐文杰
Owner 广东省中医药工程技术研究院
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