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α-glucosidase inhibitors and their applications

A diabetes and drug technology, applied in the field of medicine, can solve problems such as difficulty in exerting the best therapeutic effect of drugs, obvious side effects, and primary failure, and achieve the effect of abundant drug sources, significant curative effect, and long-lasting effect

Inactive Publication Date: 2018-06-05
HEBEI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, patients with type 2 diabetes are an organically connected whole. Many metabolic links in the body of diabetic patients are also imbalanced. It is difficult for drugs that only act on a certain target to exert the best therapeutic effect, and the side effects are relatively obvious. Primary failure , The problem of secondary failure is also more serious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Use alpha-glucosidase inhibitors to prepare medicines for preventing and treating type Ⅱ diabetes. In parts by weight, the medicines include: 5 parts of 4-thio-2'-deoxyuridine and 80 parts of the second traditional Chinese medicine active ingredient Wherein by weight, 80 parts of the second traditional Chinese medicine active ingredients are 10 parts of licorice, 13 parts of Anemarrhena, 22 parts of mulberry leaves, 3 parts of kudzu root, 13 parts of corn silk, 5 parts of coptis, 14 parts of raw land, 4 parts of cinnamon , 2 parts of Inonotus obliquus, 28 parts of dandelion, 7 parts of marching grass, 1 part of ginkgo biloba, 2 parts of perilla, 2 parts of ghost needle grass, 13 parts of purple backed genus, 6 parts of sedum notoginseng and small A mixture of 2 parts of Fly Lotus extract.

[0049] Tablets and capsules are prepared according to the above pharmaceutical formula. The content of 4-thio-2'-deoxyuridine in the tablets or capsules is 5-6 mg / g, and the content ...

Embodiment 2

[0051] The medicament for preventing and treating type Ⅱ diabetes is prepared by using an α-glucosidase inhibitor, and the medicament includes: 7 parts of 4-thio-2'-deoxyuridine and 84 parts of the active ingredient of the second traditional Chinese medicine in parts by weight Wherein by weight, 84 parts of the second traditional Chinese medicine active ingredients are 14 parts of licorice, 16 parts of Anemarrhena, 23 parts of mulberry leaves, 4 parts of kudzu root, 15 parts of corn silk, 5 parts of coptis, 14 parts of raw land, and 5 parts of cinnamon , 2 parts of Inonotus obliquus, 28 parts of dandelion, 7 parts of marching grass, 2 parts of ginkgo biloba, 2 parts of perilla, 2 parts of ghost needle grass, 13 parts of purple backed genus, 7 parts of sedum notoginseng and small A mixture of 3 parts of Fly Lotus extract.

[0052] Prepare tablets or capsules according to the above pharmaceutical formula, the content of 4-thio-2'-deoxyuridine in the tablets or capsules is 6-7 mg...

Embodiment 3

[0054] The medicament for preventing and treating type Ⅱ diabetes is prepared by using an α-glucosidase inhibitor, and the medicament includes: 10 parts of 4-thio-2'-deoxyuridine and 90 parts of the active ingredient of the second traditional Chinese medicine in parts by weight Wherein by weight, 90 parts of the second traditional Chinese medicine active ingredients are 15 parts of licorice, 17 parts of Anemarrhena, 22 parts of mulberry leaves, 3 parts of kudzu root, 15 parts of corn silk, 6 parts of coptis, 16 parts of raw land, and 4 parts of cinnamon , 2 parts of Inonotus obliquus, 28 parts of dandelion, 7 parts of marching grass, 2 parts of ginkgo biloba, 2 parts of perilla, 4 parts of ghost needle grass, 13 parts of purple backed genus, 8 parts of sedum notoginseng and small A mixture of 2 parts of Fly Lotus extract.

[0055] Prepare tablets or capsules according to the above pharmaceutical formula, the content of 4-thio-2'-deoxyuridine in the tablets or capsules is 10 mg...

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Abstract

The invention discloses an alpha-glucosidase inhibitor. The alpha-glucosidase inhibitor is prepare from 4-sulfo-2'-deoxyuridine. The alpha-glucosidase inhibitor is used for preparing drugs or prodrugs for prevention and treatment of type 2 diabetes. The alpha-glucosidase inhibitor provided by the invention can effectively inhibit the activity of alpha-glucosidase and further reduce the postprandial blood sugar content of type 2 diabetes patients. The invention also provides a medicine for the prevention and treatment of type 2 diabetes by the use of the alpha-glucosidase inhibitor, wherein the medicine is prepared from the following components in parts by weight: 5 to 10 parts of 4-sulfo-2'-deoxyuridine and 80 to 90 parts of second active ingredients of Chinese medicine. The alpha-glucosidase inhibitor and other second active ingredients of Chinese medicine are prepared proportionately to prepare a hypoglycemic health care medicine for preventing and treating the type 2 diabetes. After 12 weeks of medication, the cured and markedly effective rate is 42.7% and the efficiency is as high as 95.2%.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an α-glucosidase inhibitor and application thereof. Background technique [0002] Diabetes mellitus is an endocrine and metabolic disorder that occurs worldwide. It is caused by abnormal insulin secretion and pancreatic islet function damage. It is a relatively common chronic disease, and its main feature is hyperglycemia. Together with cancer and cardiovascular disease, it is regarded as the world's three major diseases. It is a common disease caused by the interaction of genetic and environmental factors. Diabetes not only causes hyperglycemia, but long-term hyperglycemia and metabolic disorders may also cause diabetic complications in many tissues and organs of the human body, such as diabetic cataract, atherosclerosis, peripheral nerve disease, kidney disease, and retinopathy. People's health, work and life are seriously threatened. [0003] Clinically, diabetes is divided...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7068A61K36/899A61P3/10
CPCA61K31/7068A61K36/07A61K36/16A61K36/28A61K36/288A61K36/41A61K36/484A61K36/488A61K36/535A61K36/54A61K36/605A61K36/718A61K36/804A61K36/8964A61K36/899A61K2300/00
Inventor 张秀敏张利平高志远李建龙李楼霍莉
Owner HEBEI UNIVERSITY
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