Application of clinopodium chinense total flavones in preparing medicines for protection effect of adriamycin-induced cardiotoxicity

A protective, cardiotoxic technology, applied in the field of medicine, can solve the problem of lack of effective prevention and treatment methods

Inactive Publication Date: 2014-05-28
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, assessing the degree of cardiotoxicity of doxorubicin and finding substances that can effectively relieve its card

Method used

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  • Application of clinopodium chinense total flavones in preparing medicines for protection effect of adriamycin-induced cardiotoxicity
  • Application of clinopodium chinense total flavones in preparing medicines for protection effect of adriamycin-induced cardiotoxicity
  • Application of clinopodium chinense total flavones in preparing medicines for protection effect of adriamycin-induced cardiotoxicity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 The protective effect of total flavonoids of Campanula chinensis combined with doxorubicin on the myocardium in vivo

Embodiment 11

[0023] Example 1.1 Establishment of Rat Cardiomyopathy Model Induced by Doxorubicin in Vivo

[0024] SD rats aged 6-8 weeks (Beijing Weitong Lihua, Beijing, China). Animals were acclimated for 1 week with free access to food and water. 80 rats were randomly divided into 6 groups: normal control group (control); single-administration group of total flavonoids of Pinnata chinensis (TFCC, 80mg / kg); doxorubicin model group (DOX, 3mg / kg); doxorubicin Combined administration with total flavonoids of Campanula chinensis (20, 40, 80mg / kg). The normal group and the model group were given pure water orally, and the other groups were given TFCC of the same volume and corresponding concentration. After 15 days, the model group and the combined administration group were intraperitoneally injected with doxorubicin every other day, a total of 3 times, and the other groups were injected with the same volume of normal saline. Treatment was performed 14 days after the last dose.

Embodiment 12

[0025] Example 1.2 Comparison of heart weight and body weight and detection of myocardial three enzymes

[0026] Body weight was weighed, and blood was collected from the abdominal aorta under chloral hydrate anesthesia. Blood samples were centrifuged at 3000 g for 10 minutes within one hour after collection, and then the activities of LDH, AST, and CK in plasma were determined by commercial detection kits purchased from Jiancheng Bio-engineering Institute (Nanjing, China) according to the manufacturer's instructions.

[0027] The result is as figure 1 As shown in -A, compared with the normal group, the heart weight and body weight of the doxorubicin group decreased significantly, while the combined administration group could significantly increase. Such as figure 1 -B, the content of myocardial three enzymes in the blood of the Adriamycin group increased significantly, while that of the combined administration group decreased significantly.

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Abstract

The invention discloses application of clinopodium chinense total flavones in preparing medicines for the protection effect of adriamycin-induced cardiotoxicity. The clinopodium chinense total flavones can be medicine compositions of clinopodium chinense total flavones, including various preparations of oral or parenteral administration forms. When being used in oral administration, the compositions can be tablets, capsules, soft capsules, oral liquid, syrup, granules, dropping pills, oral disintegrating tablets, sustained-release tablets, sustained-release capsules, controlled-release tablets and controlled-release capsules; when being used in parenteral administration, the compositions can be in the forms of water injection, lyophilized powder injection, sterile powder injection and infusion. Tablets and water injection are preferable dosage forms of the medicine compositions provided by the invention.

Description

technical field [0001] The invention belongs to the technical field of medicine, more specifically, the invention relates to the application of a medicinal active ingredient in the preparation of medicine, especially the application of the total flavonoids of Campanula chinensis in the preparation of medicine. Background technique [0002] Doxorubicin is an anthracycline antibiotic, which was discovered in the 1960s and used in the treatment of various cancers, and is still one of the most effective anticancer drugs. It is suitable for various tumors such as malignant lymphoma, breast cancer, lung cancer, ovarian cancer, bone and soft tissue sarcoma. However, due to severe cardiotoxicity, its clinical application has been affected to some extent. In recent years, there have been many studies on the cardiotoxicity of doxorubicin, and doxorubicin poisoning is divided into acute toxicity, subacute toxicity and chronic toxicity. Acute poisoning occurs after a single use or a c...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61P35/00A61P9/00A61K31/704
Inventor 孙晓波孙桂波许旭东陈荣昌
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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