Assays for ultrasound mediated delivery

An ultrasound-mediated, mediated technology, applied in ultrasonic/sonic/infrasonic diagnosis, application, sonic diagnosis, etc.

Inactive Publication Date: 2014-06-04
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

None of the documents mentioned above discloses the delivery of therapeutic agents as payload by activating particles

Method used

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  • Assays for ultrasound mediated delivery
  • Assays for ultrasound mediated delivery
  • Assays for ultrasound mediated delivery

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0031] exist figure 1 The automated, quantitative feedback-based USMD system 100 shown in one possible configuration includes a control module 104, a user input module 108, a display module 110, an ultrasound therapy module 112, an imaging module 116, an injection module 120, a processor 124 and electrode 128 . The imaging module 116 includes one or more of an ultrasound imaging unit 132 , a magnetic resonance imaging (MRI) unit 136 , and an optical unit 140 for fluoroscopy-based and / or photoacoustic-based imaging.

[0032] The apparatus claimed below may be implemented as system 100, control module 104, or as one or more integrated circuits containing algorithms for quantitative feedback-based USMD. The algorithm can reside in any kind of read only memory (ROM) or random access memory (RAM), and can be input by line, or received by controller 104 wirelessly via an antenna and from a remote transmit antenna. In either case, the signal to be transmitted is generated by varyin...

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PUM

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Abstract

Ultrasound mediated delivery (USMD), real-time quantitative feedback derived (S264) therefrom, and proceeding by the system based on the feedback all are, in some embodiments, operable automatically and without need for user intervention. USMD may occur in a clinical setting accompanied by assays (S276) or real-time feedback, or by means of a wearable device that, based on feedback, regulates USMD in real time. Optionally, the user is provided an indication (S281) as to progress or success, of a treatment. Electrodes (128) may be attached across tissue in which transient pores are produced via sonoporation in the USMD procedure, and in vivo measurement is taken of an electrical parameter responsive to permeability. Therapeutic agent (S202) may be administered after particles activated for sonoporation are cleared from the circulation, to avoid, when it might exist, adverse interaction between the particles and agent.

Description

technical field [0001] The present invention relates to ultrasound mediated delivery, and more particularly to quantitative feedback and proceeding based on said feedback. Background technique [0002] Ultrasound-mediated delivery (USMD) of drugs, genetic material, and other therapeutic agents is a promising therapeutic application of ultrasound. In these approaches, the particle (nanoparticle, liposome, microcapsule, microbubble, etc.) incorporates the therapeutic agent on its surface, within its outer envelope, within the particle core, or in the vicinity of the particle. Spatially localized treatment is achieved by site-targeted delivery using specific targeting ligands and by exposing a volume of tissue to activating ultrasound energy. Targeting ligands are capable of binding to specific pathological antigenic epitopes and can be bound to particle surfaces through avidin-biotin bonding, chemical or electrostatic interactions. Afterwards, ultrasound was introduced to en...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K41/00A61B5/00A61B8/00
CPCA61B5/6805A61B5/4839A61B5/14546A61M37/0092A61B6/032A61B8/4227A61M2037/0007A61B8/08A61B6/037
Inventor T·N·埃尔佩丁R·塞普C·S·霍尔B·I·拉朱
Owner KONINKLJIJKE PHILIPS NV
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