Application of 5,6,7,8-tetrahydroxyflavone in the preparation of anti-hypoxic drugs

A kind of technology of tetrahydroxyflavone and medicine, applied in the field of medicine

Active Publication Date: 2016-06-29
中国人民解放军联勤保障部队第九四〇医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are few reports on the biological activity of 5,6,7,8-tetrahydroxyflavone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] The present invention will be further described below in conjunction with specific examples, but the protection scope of the present invention is not limited thereto.

[0037] With 5,6,7,8-tetrahydroxyflavone as the active ingredient, various formulations of anti-hypoxic drugs are prepared according to the conventional process of pharmacy.

[0038] Prescription 1: 5,6,7,8-Tetrahydroxyflavone Tablets

[0039] 5,6,7,8-Tetrahydroxyflavone (purity greater than 95%) 50.0g

[0040] Starch 125.0g

[0041] Microcrystalline cellulose (MCC) 15.0g

[0042] Methylcellulose 6.0g

[0043] Magnesium stearate 4.0g

[0044] Total 200.0g

[0045] Prepared according to the conventional tablet method, a total of 1000 tablets were made, and each tablet contained 50 mg of 5,6,7,8-tetrahydroxyflavone.

[0046] Prescription 2: 5,6,7,8-tetrahydroxyflavone capsules

[0047] 5,6,7,8-Tetrahydroxyflavone (purity greater than 95%) 50.0g

[0048] Starch 135.0g

[0049] Methylcellulose 5.0g

...

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PUM

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Abstract

The invention discloses a novel use of 5,6,7,8- tetrahydroxyflavone, namely an application in preparing an anti-hypoxic drug. The anti-hypoxic drug prepared by the 5,6,7,8- tetrahydroxyflavone has obvious anti-hypoxic activity, and can be used for preventing or treating high-altitude low-pressure oxygen deficit-caused acute high altitude diseases, cerebral ischemia hypoxic diseases or myocardial ischemia hypoxic diseases.

Description

technical field [0001] The invention belongs to the field of medicine, and particularly relates to the application of 5,6,7,8-tetrahydroxyflavone in the preparation of anti-hypoxic drugs. Background technique [0002] Hypoxia is a pathological condition when oxygen supply to parts of the body or tissues throughout the body is insufficient. The pace of life of modern people is constantly accelerating, and hypoxia has become a fairly common phenomenon. The plateau environment is also one of the most common conditions for ordinary people to experience hypoxia. The special low-pressure and hypoxic environment often makes people who rush to the plateau very prone to acute altitude sickness, and in severe cases, high-altitude pulmonary edema, high-altitude cerebral edema, etc. Fatal diseases, long-term exposure to hypoxic environments can also cause chronic altitude sickness, which seriously affects the health of plateau residents or sojourners. At the same time, hypoxia is also...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P39/00A61P9/10
Inventor 马慧萍樊鹏程景临林何蕾王宁贾正平
Owner 中国人民解放军联勤保障部队第九四〇医院
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