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A kind of detection method of sumatriptan purity

A detection method and purity technology, which is applied in the field of purity detection, can solve problems such as not meeting the purity determination method of sumatriptan, and achieve the effects of good repeatability, simple quantitative method, and accurate results

Active Publication Date: 2015-09-23
CHEM TECH ACAD OF SHANDONG PROVINCE
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Problems solved by technology

[0003] At present, there is no purity determination method that meets the characteristics of sumatriptan. Therefore, establishing a simple and accurate detection method for the determination of the purity of sumatriptan is of great significance for the quality monitoring of sumatriptan.

Method used

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  • A kind of detection method of sumatriptan purity
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  • A kind of detection method of sumatriptan purity

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Embodiment Construction

[0019] In order to better understand the present invention, the technical solutions of the present invention will be described in detail below with specific examples, but the present invention is not limited thereto.

[0020] Column: C 18 Column (specification: 250mm×4.6mm, 5μm)

[0021] The operating conditions of high performance liquid chromatography: the column temperature was selected to be 30°C, and gradient elution was adopted, and the elution gradient was shown in Table 1.

[0022] Table 1: Mobile phase ratio

[0023]

[0024] Preparation of sample solution: Weigh 0.0025g sample into a 10mL volumetric flask, dissolve and dilute to the mark with acetonitrile, shake well, pass through a 0.45μm organic filter membrane, and then inject the sample for analysis;

[0025] Injection volume: 20μL;

[0026] Sumatriptan was quantified by the area normalization method according to w i =(A i / ∑A i )×100 to calculate the sumatriptan purity in the sample, where: w i —The pe...

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Abstract

The invention discloses a method for detecting the purity of sumatriptan. A high performance liquid chromatography-ultraviolet detector is adopted for detection, a gradient elution mode is adopted for separation, the content of sumatriptan is measured by an area normalization method, and the method for detecting the purity of sumatriptan is provided.

Description

technical field [0001] The invention belongs to the technical field of purity detection, in particular to a method for detecting the purity of sumatriptan. Background technique [0002] Sumatriptan (Sumtriptan), chemically named 3-(2-dimethylamino)ethyl-N-methyl-1H-indole-5-methanesulfonamide, is a highly selective and potent 5-HT1B / 1D receptor agonists can constrict intracranial arteries, redistribute blood, and improve cerebral blood supply, thereby rapidly alleviating severe headache attacks. It is a first-aid medicine for migraine and cluster headache attacks. Because the drug has the advantages of less toxic side effects and ideal selective anti-migraine activity, its discovery is considered a scientific breakthrough in the research of anti-migraine drugs. After continuous development, sumatriptan has become a first-line treatment drug. It has good clinical application value. [0003] At present, there is no purity determination method that meets the characteristics ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 邱娟于朋玲王瑞菲陈菊
Owner CHEM TECH ACAD OF SHANDONG PROVINCE
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