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Formula composition and preparation system of enalapril (Enalapril) cutaneous penetration preparations

A technology for transdermal drug delivery and enalapril, which is used in drug combinations, cardiovascular system diseases, active ingredients of heterocyclic compounds, etc.

Inactive Publication Date: 2014-08-20
鑫稳药泰医药科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, not all drugs can be administered transdermally

Method used

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  • Formula composition and preparation system of enalapril (Enalapril) cutaneous penetration preparations

Examples

Experimental program
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Effect test

Embodiment Construction

[0062] The implementation method is to apply the enalapril transdermal delivery preparation system to the target object, and transdermally inject the target dose of enalapril into the target object according to the required component formula, so as to achieve the curative effect on the disease.

[0063] The target object is mainly a human body or a sick body, but not limited to a human body, and also includes animals such as dogs and cats.

[0064] In practice, the enalapril transdermal drug delivery system described in the present invention can be applied to any convenient keratinous skin site of the target object, including but not limited to, upper arm, lower arm, leg, trunk, etc. The surface area covered by the enalapril transdermal drug delivery system should provide sufficient enalapril transdermal dose.

[0065] During specific implementation, firstly, the release layer of the enalapril transdermal drug delivery preparation is peeled off, and the drug reservoir layer is...

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Abstract

The invention relates to an enalapril (Enalapril) cutaneous penetration preparation which is used for delivering enalapril in a therapeutic dose to a human body through skin and serves as a new enalapril dosage form for treating hypertension. The enalapril (Enalapril) cutaneous penetration preparation comprises a three-layer structure, namely a backing layer, a drug storage layer and a release layer. The formula provided by the invention comprises a provided transdermal absorption enhancer. The enalapril (Enalapril) cutaneous penetration can be prepared.

Description

technical field [0001] This patent relates to an enalapril (Enalapril) transdermal drug delivery preparation, which is characterized in that the drug is delivered into the body through the skin. [0002] Enalapril is a second-generation angiotensin-converting enzyme inhibitor antihypertensive drug. Molecular formula C20H28N205. [0003] Hypertension is the most common chronic disease and the most important risk factor for cardiovascular and cerebrovascular diseases. Stroke, myocardial infarction, heart failure and chronic kidney disease are its main complications. [0004] Enalapril, as a prodrug, exerts its ACE inhibitory effect after being metabolized in the liver to the active drug enalaprilat. Enalaprilat mainly inhibits angiotensin-converting enzyme, so that angiotensin I cannot be converted into angiotensin II, thereby causing the relaxation of blood vessels throughout the body, and finally achieving the effect of lowering blood pressure. [0005] Transdermal drug del...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/40A61P9/12
Inventor 章新罗芳芳
Owner 鑫稳药泰医药科技(上海)有限公司
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