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Applications of histone deacetylase inhibitor in preparing antishock drug

An anti-shock and multi-purpose technology, applied in the field of preparing anti-shock drugs, can solve the problems of anti-shock and other problems that have not been seen

Inactive Publication Date: 2014-09-17
胡森
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] At present, there is no research on the use of compound NK-HDAC-1 in the preparation of anti-shock, especially burn and scald shock drugs

Method used

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  • Applications of histone deacetylase inhibitor in preparing antishock drug
  • Applications of histone deacetylase inhibitor in preparing antishock drug
  • Applications of histone deacetylase inhibitor in preparing antishock drug

Examples

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Embodiment Construction

[0034] Those skilled in the art will better understand the present invention by reading the following examples. These examples serve only to illustrate the present invention.

[0035] The experimental methods not indicating specific conditions in the examples of the present invention are generally in accordance with conventional conditions, or in accordance with the conditions suggested by raw material or commodity manufacturers. Reagents without specific sources indicated are conventional reagents purchased in the market.

[0036] 1. Materials and Instruments

[0037] NK-HDAC-1 was provided by the State Key Laboratory of Medicinal Chemistry and Biology, School of Pharmacy, Nankai University;

[0038] Sodium valproate (VPA) was purchased from Sigma, USA;

[0039] Suberoylanilide hydroxamic acid (SAHA) was purchased from Sigma, USA;

[0040] The above reagents are prepared and used immediately before the experiment.

[0041] Automatic biochemical analyzer: Hitachi, Japan; ...

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PUM

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Abstract

The invention relates to applications of a histone deacetylase inhibitor in preparing an antishock drug, especially applications of S-(E)-3-[1-(1-benzo[d]oxazole-2-yl)-2-methylpropyl]-1H-1,2,3-triazole-4-yl]-N-Methylol acrylamide as shown in the specification in preparing the antishock drug, the shock is preferably selected from traumatic shock, hypovolemic shock, infectious shock, neurogenic shock, cardiogenic shock and anaphylactic shock, especially burning shock preferably.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular, the invention relates to the use of histone deacetylase inhibitors in the preparation of anti-shock medicines. Background technique [0002] Shock refers to a state in which the perfusion of surrounding tissues is insufficient due to insufficient cardiac output or abnormal distribution of peripheral blood flow, which cannot sustain life. Usually, there are hypotension and oliguria. Shock can be caused by hypovolemia, vasodilation, cardiogenic, or a combination of these factors. The common classifications of shock are: [0003] (1) Hypovolemic shock: refers to the loss of active components in blood, including hemorrhagic shock, plasma depletion shock and fluid depletion shock. [0004] (2) Traumatic shock: In addition to the reduction of effective circulation caused by blood loss and fluid loss, the toxin effect of tissue post-traumatic decomposition products and strong pain sti...

Claims

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Application Information

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IPC IPC(8): A61K31/423A61P7/08A61P17/02A61P31/00A61P9/00A61P25/00A61P37/08
Inventor 胡森王晓青孟祥熙
Owner 胡森
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