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A near-infrared online detection method in the production process of traditional Chinese medicine containing naringin

A technology of production process and detection method, applied in the direction of measuring device, material analysis by optical means, instrument, etc., can solve the problems of lack of rapid non-destructive determination of active ingredient content, inability to solve quality control problems in key process links, etc. Conducive to the whole process control, improve product quality stability, simplify the model effect

Active Publication Date: 2016-08-17
广东省中医药工程技术研究院
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Problems solved by technology

[0003] At present, the production process of traditional Chinese medicine containing naringin lacks a rapid and non-destructive determination method for the content of active ingredients, which cannot solve the quality control problems of key process links, making it difficult to solve the stability and reliability of Yinlantiaozhi capsule technology and ingredients from the source of the product.

Method used

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  • A near-infrared online detection method in the production process of traditional Chinese medicine containing naringin
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  • A near-infrared online detection method in the production process of traditional Chinese medicine containing naringin

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Embodiment 1

[0039] The near-infrared spectrometer used in this embodiment is the Luminar 3060 acousto-optic tunable online near-infrared spectrometer (No. 1112-SP-10979) from Brimrose, USA. The main components include: optical part, control part, 675 transflective probe, DN25 fluid sample test It is composed of parts such as the device and optical fiber. The detector used in the instrument is InGaAs. In this example, the equipment for extraction, concentration, alcohol precipitation, and ethanol recovery in the production process of Yinlantiaozhi capsules is an automation equipment of Guangzhou Baiyunshan Hanfang Modern Pharmaceutical Co., Ltd. The material mixing process uses Nicolet 6700 Fourier Transform Infrared Spectrometer (Thermo Nicolet Company, USA), equipped with integrating sphere diffuse reflection sampling system and Omni signal acquisition software. This embodiment also relates to Agilent1200 high performance liquid chromatograph, Mettler XS205DU electronic analytical balanc...

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Abstract

The invention provides a near-infrared online detection method in the production process of traditional Chinese medicine containing naringin, which comprises the following steps: collecting samples in the production process of traditional Chinese medicine containing naringin and collecting their near-infrared spectra; The content of naringin; according to the near-infrared spectrum of the sample and the naringin content recorded by the prior art, a detection model is established by chemometrics software, and the spectral range of the near-infrared spectrum is selected for the establishment of the detection model to be 1100~ 2300nm; collect the sample to be tested, and use the detection model to determine the naringin content and map similarity. The near-infrared online detection method in the production process of the traditional Chinese medicine containing naringin provided by the invention can effectively solve the problems of low efficiency of the quality analysis method and excessive waste of raw materials in the production process of the traditional Chinese medicine containing naringin.

Description

Technical field [0001] The invention belongs to the technical field of Chinese medicine extraction and preparation, and specifically relates to a near-infrared online detection method in the production process of Chinese medicine containing naringin. Background technique [0002] The production of traditional Chinese medicine compound preparations is a complex manufacturing process, and changes in different raw materials and various process parameters during the production process can lead to unstable quality of the final product. The quality control in the production process mainly relies on experience and traditional quality analysis methods, and lacks effective real-time monitoring methods for the content of index components. In actual production, the extraction time is often fixed, and it basically does not take into account the early or delayed extraction endpoint caused by the quality difference of the raw materials and the fluctuation of the working conditions, which is ea...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/359
Inventor 孙冬梅王洛临毕晓黎陈玉兴李智勇
Owner 广东省中医药工程技术研究院
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