Application of chrysanthemum extract in preparation of health food and medicine for prevention and treatment of hyperglycemia

A technology of health food and extract, which is applied in the application field of Chrysanthemum chrysanthemum extract in the preparation of health food and medicines for the prevention and treatment of hyperglycemia, and can solve problems such as no relevant literature reports

Active Publication Date: 2018-06-15
中广健科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Chrysanthemum and other Chinese herbal medicines have been combined to prepare medicinal wine or health tea that protects the liver, regulates blood lipids, dredges collaterals, treats thromboangiitis, treats rhinitis, treats colds, and fights cancer. Preparation of sterilizing air fresheners, but there is no relevant literature report on the prevention and treatment of hyperglycemia with Chrysanthemum chrysanthemum extract enriched in phenolic acids alone

Method used

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  • Application of chrysanthemum extract in preparation of health food and medicine for prevention and treatment of hyperglycemia
  • Application of chrysanthemum extract in preparation of health food and medicine for prevention and treatment of hyperglycemia
  • Application of chrysanthemum extract in preparation of health food and medicine for prevention and treatment of hyperglycemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Effect experiment of Chrysanthemum chrysanthemum extract on blood sugar in normal mice

[0015] (1) Experimental drugs and reagents: Chrysanthemum chrysanthemum extract, 0.5% sodium carboxymethyl cellulose solution, etc. Before the medicine, the Chrysanthemum chrysanthemum extract is prepared into a medicine with a concentration of 1.5% with 0.5% sodium carboxymethyl cellulose solution.

[0016] (2) Experimental mice: Kunming mice, male, weighing 20-22 grams, supplied by Shanghai Slack Experimental Animal Co., Ltd., clean grade, experimental animal production license number: SCXK (Shanghai) 2012-0002, experimental Animal use license: SYXK (Su) 2012-0045.

[0017] (3) Experimental methods and results:

[0018] 20 male Kunming mice were randomly divided into normal control group and Hangju extract administration group, with 10 mice in each group. The mice in the administration group were given 300mg / kg of Chrysanthemum extract (that is, 0.2ml / 10g body weight...

Embodiment 2

[0023] Example 2: Effect of Chrysanthemum Chrysanthemi Extract on Glucose Tolerance in Normal Mice

[0024] Experimental medicaments and experimental mice are the same as in Example 1.

[0025] Experimental method and results:

[0026] 20 male Kunming mice were randomly divided into normal control group and Hangju extract administration group, with 10 mice in each group. The mice in the administration group were given 300mg / kg of Chrysanthemum extract (that is, 0.2ml / 10g body weight with 1.5% Chrysanthemum chrysanthemum extract solution) for oral gavage every day, and the mice in the normal control group were given an equal volume of 0.5% carboxymethyl cellulose Sodium solution, administered continuously for 45 days. On the next day, after fasting for 4 hours, blood from the retro-orbital venous plexus of the two groups of mice was taken to measure the blood sugar level as the zero-time blood sugar. All mice were intraperitoneally injected with glucose 2g / kg, and blood was ...

Embodiment 3

[0031] Example 3: Effect of Chrysanthemum Chrysanthemi Extract on Blood Glucose in Alloxan Hyperglycemic Mice

[0032] Other experimental agents and experimental mice in this embodiment 3 are the same as in embodiment 2. Wherein, before use, the Chrysanthemum chrysanthemum extract was prepared into concentrations of 0.75% and 1.5% respectively with 0.5% sodium carboxymethylcellulose solution; the reference drug was Xiaoke Pill, produced by Guangzhou Zhongyi Pharmaceutical Co., Ltd. 0.5% sodium carboxymethylcellulose solution was prepared to a drug concentration of 3.0%; alloxan was purchased from Sigma-Aldrich Company.

[0033] Male Kunming mice were randomly divided into normal control group and hyperglycemia model group. The mice in the hyperglycemia model group were given intravenous injection of alloxan 58mg / kg, and blood was collected from the retro-orbital venous plexus of the mice after 72 hours to measure the fasting (fasting for 4 hours) blood glucose level, and the ...

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Abstract

An application of a Hangzhou chrysanthemum extract product in preparation of healthcare foods and medicines for preventing and treating hyperglycemia is disclosed. The Hangzhou chrysanthemum extract product is prepared into a medicine for animals and is administrated to mice by perfusion. Influences of the medicine prepared from the Hangzhou chrysanthemum extract product on blood glucose of normal mice, influences of the medicine on the glucose tolerance of normal mice, and influences of different concentrations of the medicine on glucose of mice with hyperglycemia induced by alloxan are measured. Results show that: long-term taking of the Hangzhou chrysanthemum extract product can reduce the blood glucose concentration of the normal mice, and reduce the blood glucose concentration of the mice with hyperglycemia induced by glucose and the alloxan. The Hangzhou chrysanthemum extract product can be used for healthcare foods and medicines for preventing and treating the hyperglycemia.

Description

technical field [0001] The invention relates to a new application of Chrysanthemum chrysanthemum, more specifically, the application of Chrysanthemum chrysanthemum extract in preparing health food and medicine for preventing and treating hyperglycemia. Background technique [0002] With the continuous improvement of people's living standards and changes in lifestyles, the incidence and number of hyperglycemia continue to increase. Long-term hyperglycemia can cause lesions in some related tissues and organs throughout the body, leading to acute and chronic complications. Such as decreased resistance, impaired renal function, neuropathy, fundus lesions, nutritional deficiencies, etc. Diabetes, characterized by elevated blood sugar, currently has 136 million patients across the country. There are also many drugs and health foods for the clinical treatment of diabetes, mainly biguanides, α-glucosidase inhibitors and thiazolidinediones. [0003] Chrysanthemum chrysanthemum is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/216A61K36/287A23L33/105A61P3/10
Inventor 谢梅林尚翔刘江云薛洁
Owner 中广健科技有限公司
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