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Preparation method of freeze-dried powder sample of toltrazuril in chicken meat and toltrazuril sulphone residue

A technology of toltrazuril sulfone and toltrazuril, which is applied in the field of preparation of standard samples of toltrazuril and toltrazuril sulfone residual freeze-dried powder in chicken, can solve the problems of lack of physical standards and achieve significant economic The effect of value and market competitiveness, convenient transportation, uniform and stable samples

Inactive Publication Date: 2014-11-19
威海出入境检验检疫局检验检疫技术中心 +1
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Problems solved by technology

At present, my country's written standards are relatively complete, but physical standards, especially physical standards for food safety testing, are still scarce

Method used

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  • Preparation method of freeze-dried powder sample of toltrazuril in chicken meat and toltrazuril sulphone residue
  • Preparation method of freeze-dried powder sample of toltrazuril in chicken meat and toltrazuril sulphone residue
  • Preparation method of freeze-dried powder sample of toltrazuril in chicken meat and toltrazuril sulphone residue

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Embodiment 1

[0013] Example 1, a method for preparing a standard sample of toltrazuril and its metabolite toltrazuril sulfone residual freeze-dried powder in chicken, this example takes the control target content level of 20-100ug / kg as an example, and its specific steps as follows:

[0014] (1) Selection of experimental animals: Broiler chickens purchased from the market are required to be of uniform size and average weight of about 2.5 kg. First, confirm that the broiler chickens have not been fed with toltrazuril, and randomly sample them. After the test confirms that the samples are negative, they can be fed. After 5 days of normal feeding, the injured and unhealthy chickens were removed.

[0015] (2) Feeding with drugs: Accurately weigh 0.2 mg of toltrazuril powder, put it into capsules, feed each chicken with 1 capsule per day, and feed it for 2 consecutive days, slaughter it 10 hours after stopping the drug on the second day, and take the breast muscle Detection, at this time the ...

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Abstract

The invention belongs to the technical field of a standard sample of an animal-sourced substrate drug in detection of veterinary drug residue and discloses a preparation method of a freeze-dried powder sample of toltrazuril in chicken meat and a toltrazuril sulphone residue. The method includes following steps: feeding chicken with the toltrazuril; enabling the toltrazuril and a metabolite toltrazuril sulphone to remain in chicken after toltrazuril sulphone with time controlling; killing the chicken to obtain breast muscle; performing a skin removing and blood draining process; adding a vitamin C solution; performing a homogenizing process to obtain meat paste; performing a vacuum freeze-drying process and a crushing and sieving process; performing a nitrogen-filling packaging process in an anaerobic work station; performing a vacuum packaging process to a polyethylene bottle with an aluminium foil bag after a sealing process being carried out to obtain a standard sample of the freeze-dried powder. The sample can be transported at normal temperature and is long in preserving time. A situation of combination of a target object and the substrate is coincided with that of an actual detection sample. The sample can be used of quality controlling of relative detection and analysis, is homogeneous and stable, is convenient to transport, is reliable in use and has significant economic value and market competitiveness.

Description

technical field [0001] The invention belongs to the technical field of animal source matrix standard samples for detection of veterinary drug residues, and in particular relates to a method for preparing a standard sample of toltrazuril and toltrazuril sulfone residue freeze-dried powder in chicken. Background technique [0002] Toltrazuril, Chinese name: Methyltriazone, Baiqiuqing, English name: Toltrazuil, CAS number: 69004-03-1, molecular formula: C 18 h 14 f 3 N 3 o 4 S, a triazinone compound, has broad-spectrum anticoccidial activity and is widely used in chicken coccidiosis. Toltrazuril sulfone, Chinese name: Patopazuril, Panazuril, English name: Toltrazuril sulfone, Ponazuril, CAS number: 69004-04-2, molecular formula: C 18 h 14 f 3 N 3 o 6 S. [0003] More than 50% of the drug is absorbed by poultry after oral administration of Toltrazuril. After absorption, the drug is mainly collected in the liver and kidney, where it is rapidly metabolized into Toltrazur...

Claims

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Application Information

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IPC IPC(8): G01N1/28G01N33/00
Inventor 杨丽君王静刘玉敏胡巧茹李兆杰王美玲
Owner 威海出入境检验检疫局检验检疫技术中心
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