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Application of composition in preparation of medicine for treating type 2 diabetes

A technology of type 2 diabetes and composition, which is applied in the direction of drug combination, metabolic disease, cardiovascular system disease, etc., and can solve problems such as high price and unsatisfactory efficiency

Inactive Publication Date: 2015-01-14
WUXI XINDA MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, in the prior art, the drugs for the treatment of type 2 diabetes are often expensive and the efficiency is often unsatisfactory.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Application of a composition in the preparation of a drug for treating type 2 diabetes, the composition comprising a therapeutically effective amount of 1'-(1H-indazole-5-carbonyl)-1-isopropyl-4,6-di Hydrogenspiro[indazole-5,4'-piperidin]-7(1H)-one, and a therapeutically effective amount of 4-[5-cyano-4-({2-fluoro-4-[1-(2 -Hydroxyethyl)-1H-tetrazol-5-yl]phenoxy}methyl)-1H-pyrazol-1-yl]piperidine-1-carboxylic acid isopropyl ester, the mass ratio of the two is 1: 1.

[0020] Experiments have proved that the combined use of the two drugs can effectively treat type 2 diabetes, and while treating type 2 diabetes, it can also treat accompanying symptoms such as hypertension and diabetes.

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PUM

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Abstract

The invention discloses application of a composition in preparation of a medicine for treating type 2 diabetes. The composition contains a therapeutically-effective amount of 1'-(1H-indazol-5-carbonyl)-1-isopropyl-4,6-dihydrospiro[indazol-5,4'-piperidine]-7(1H)-one and a therapeutically-effective amount of 4-[5-cyano-4-({2-fluoro-4-[1-(2-hydroxyethyl)-1H-tetrazol-5-yl]phenoxy}methyl)-1H-pyrazol-1-yl]piperidin-1-isopropyl formate which have the mass ratio of (3: 1) to (1: 3). The composition of the medicine can be used for effectively treating the type 2 diabetes.

Description

technical field [0001] The invention relates to a medicine, in particular to the application of a composition in the preparation of a medicine for treating type 2 diabetes. Background technique [0002] Diabetes (diabetes) is a sugar, protein, A series of metabolic disorder syndromes including fat, water and electrolytes, clinically characterized by hyperglycemia, polyuria, polydipsia, polyphagia, weight loss, etc. Blood sugar) Once it is not well controlled, it will cause complications, leading to failure and lesions of the kidneys, eyes, feet and other parts, and it cannot be cured. [0003] Patients with type 2 diabetes do not need to rely on insulin and can use oral hypoglycemic drugs to control blood sugar, also known as non-insulin-dependent diabetes. The so-called "type 2 diabetes" is formed after a long pathological process under the action of various pathogenic factors. Due to the existence of pathogenic factors, the normal blood structure balance is destroyed, a...

Claims

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Application Information

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IPC IPC(8): A61K31/454A61K31/438A61P3/10A61P9/12
CPCA61K31/454A61K31/438
Inventor 王岳荣
Owner WUXI XINDA MEDICAL DEVICE