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Preparation method of fomes officinalis cough and asthma treating tablets and application of fomes officinalis cough and asthma treating tablets in preparation of medicine for inhibiting cell proliferation of mouse teratoma cell P19

An Alihong Kechuan Tablet and its extraction technology are applied to antineoplastic drugs, drug combinations, and medical preparations containing active ingredients. There is no bitterness in the dose, and the effect of reducing the dose

Inactive Publication Date: 2015-01-21
JINAN XINQIDIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report that Alihong Kechuan Oral Liquid adopts supercritical extraction and microwave extraction technology in the extraction and preparation. However, the extraction of volatile oil and the method of water heating extraction are rough and backward in process and have many impurities, resulting in a large dosage for patients. Large, inconvenient to take, seriously affecting the clinical application of this product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 20g of Alihong, 100g of Plum, 80g of Reed Root, 60g of Licorice, 50g of Ephedra, 30g of Woody Fragrance, 120g of Anise, 30g of Cyperus Cyperi, 20g of Cardamom. 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 3L of 70% ethanol, and put into a microwave extraction device for microwave extraction, the extraction power is 700W, and the extraction is performed twice, For 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obt...

Embodiment 2

[0034] Take 20g of Alihong, 100g of Plum, 80g of Reed Root, 60g of Licorice, 50g of Ephedra, 30g of Woody Fragrance, 120g of Anise, 30g of Cyperus Cyperi, 20g of Cardamom. 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 3L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 600W, and the extraction is performed twice. Combine the extracts for 5 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to ...

Embodiment 3

[0037] Take 20g of Alihong, 100g of Plum, 80g of Reed Root, 60g of Licorice, 50g of Ephedra, 30g of Woody Fragrance, 120g of Anise, 30g of Cyperus Cyperi, 20g of Cardamom. 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2The flow rate is 1ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 3L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 800W, and the extraction is performed twice. For 10 minutes each time, combine the extracts, concentrate, add to the D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain th...

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PUM

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to a preparation method and application of fomes officinalis cough and asthma treating tablets. According to the preparation method of the fomes officinalis cough and asthma treating tablets, disclosed by the invention, the fomes officinalis cough and asthma treating tablets are prepared from the raw pharmaceutical materials by weight: 20g of fomes officinalis, 100g of plums, 80g of reed rhizomes, 60g of glycyrrhiza uralensis, 50g of herba ephedrae, 30g of elecampane, 120g of aniseed, 30g of nutagrass flatsedge rhizome and 20g of cardamom, through supercritical extraction and microwave extraction, so that the content of glycyrrhizic acid is greatly increased. The invention further provides the application of the fomes officinalis cough and asthma treating tablets in preparation of a medicine for inhibiting the cell proliferation of a mouse teratoma cell P19.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Alihong Kechuan Tablet and its application in medicines for inhibiting the proliferation of mouse teratoma cell P19 cells. Background technique [0002] The standard number of Alihong Kechuan Oral Liquid is WS-10245(ZD-0245)-2002, which is recorded in the Department of Internal Medicine and Pulmonary Department of the National Compilation of Chinese Patent Medicine Standards. It is made from 20g of Alihong, 100g of Plum, 80g of Reed Root, 60g of Licorice, 50g of Ephedra, 30g of Woody Fragrance, 120g of Anise, 30g of Cyperus Cyperi, and 20g of Cardamom. For cold cough, expectoration, acute and chronic bronchitis, asthma. [0003] In the prior art, there is no report on the use of supercritical extraction and microwave extraction technology in the extraction and preparation of Alihong Kechuan Oral Liquid. However, the metho...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61K9/20A61P35/00A61P11/14A61P11/06A61P11/10
CPCA61K36/07A61K9/2059A61K36/17A61K36/23A61K36/285A61K36/484A61K36/738A61K36/8905A61K36/899A61K36/9064A61K2236/333A61K2236/37A61K2236/39A61K2236/55
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
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