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Use of a creatine phosphate disodium salt in the preparation of anti-cancer-related fatigue medicine

A technology for creatine phosphate disodium salt and cancer-related fatigue, which is applied in the field of medicine, can solve the problems of anti-cancer-related fatigue and other problems of creatine phosphate disodium salt, and achieves prevention or treatment of cancer-related fatigue, improvement of Blood count, reducing the effect of myelosuppression

Active Publication Date: 2017-03-15
QIDONG HUATUO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] At present, there is no literature at home and abroad to report that creatine phosphate disodium salt has the pharmacological effect of anti-cancer fatigue.

Method used

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  • Use of a creatine phosphate disodium salt in the preparation of anti-cancer-related fatigue medicine
  • Use of a creatine phosphate disodium salt in the preparation of anti-cancer-related fatigue medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1, Creatine Phosphate Disodium Salt on Antibody Fatigue Effect of Mouse Model.

[0025] 1. Experimental animals

[0026] SPF (Specific Pathogen Free) level ICR mice, from Shanghai Slack Experimental Animal Center, were 8 weeks old at the beginning of the experiment, weighing 22-26 g at the beginning of the experiment, 40 males.

[0027] Breeding conditions: room temperature 18°C-26°C, relative humidity 30%-70%, 12 hours of light, free water and food, 3-7 days before the experiment.

[0028] 2. Experimental samples

[0029] Creatine phosphate disodium salt (CPS) is creatine phosphate sodium for injection produced by Harbin Laibotong Pharmaceutical Co., Ltd., which is creatine phosphate disodium salt tetrahydrate. The doses in the experimental methods are calculated on the basis of no water of crystallization. Before the experiment, it was dissolved with physiological saline to make a solution of corresponding concentration, and it was prepared and used now.

...

Embodiment 2

[0037] Example 2, the effect of creatine phosphate disodium salt on the effect of chemotherapy on the xenograft tumor mouse model and the hemogram after chemotherapy.

[0038] 1. Experimental animals

[0039] BALB / c nude mice, 30, female, 4-6 weeks old, weighing 17-20 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (permit number: SCXK (Beijing) 2012-0001). Breeding environment: SPF grade animal room, free feeding, 12h light / 12h dark.

[0040] 2. Materials and samples

[0041] Creatine phosphate disodium salt (CPS) is creatine phosphate sodium for injection produced by Harbin Laibotong Pharmaceutical Co., Ltd., which is creatine phosphate disodium salt tetrahydrate. The doses in the experimental methods are calculated on the basis of no water of crystallization. Before the experiment, it was dissolved with physiological saline to make a solution of corresponding concentration, and it was prepared and used now. Cisplatin (Cisplatin), ba...

Embodiment 3

[0049] Example 3, the anti-mental fatigue effect of creatine phosphate disodium salt on transplanted tumor mouse model.

[0050] 1. Experimental animals

[0051] ICR mice, 48, female, 4-6 weeks old, weighing 17-20 g, were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. (permit number: SCXK (Beijing) 2012-0001). Breeding environment: SPF grade animal room, free feeding, 12h light / 12h dark.

[0052] 2. Materials and samples

[0053] Creatine Phosphate Disodium Salt (CPS) is creatine phosphate disodium salt dihydrate. The doses in the experimental methods are calculated on the basis of no water of crystallization. Before the experiment, it was dissolved with physiological saline to make a solution of corresponding concentration, and it was prepared and used now. Cisplatin (Cisplatin), batch number: 1WA1A1302006B, 10mg / bottle, produced by Qilu Pharmaceutical Co., Ltd. Solvent: sodium chloride injection, batch number: 13010501, produced by Yabang ...

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Abstract

The invention discloses use of a creatine phosphate disodium salt in preparation of a medicine for resisting cancer-related fatigue. An animal model experiment proves that the creatine phosphate disodium salt has a significant effect of resisting physical fatigue, and is capable of reducing myelosuppression caused by chemotherapy and improving mental fatigue caused by cancers, therefore, the creatine phosphate disodium salt can be used for preparing the medicine for resisting the cancer-related fatigue.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the use of creatine phosphate disodium salt in the preparation of anti-cancer fatigue medicine. Background technique [0002] Cancer-related fatigue (Cancer-Related Fatigue, CRF) is one of the most common subjective symptoms of cancer patients. The National Cancer Network of the United States defined it in the "Cancer-Related Fatigue Practice Guidelines" published in 2007: cancer-related fatigue is A painful, persistent, subjective feeling of weakness or exhaustion, out of proportion to activity, associated with cancer or cancer treatment and often accompanied by functional impairment. [0003] CRF is characterized by persistence and non-university, which is related to cancer itself and cancer treatment that affects physiological functions, and is different from fatigue in healthy people. CRF has two meanings: ① Subjective feeling, characterized by decreased physica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/664A61P39/00A61P35/00
CPCA61K31/664
Inventor 潘俊芳曾佳烽李宝莹吴光明方通朱勤
Owner QIDONG HUATUO PHARMA
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