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nasal delivery device

A delivery device and nasal cavity technology, which can be used in drug devices, inhalers, other medical devices, etc., and can solve problems such as liver first-pass effect, cost-effective delivery obstacles, etc.

Active Publication Date: 2018-06-01
OPTINOSE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this substance, intestinal metabolism and hepatic first-pass effects create significant barriers to reliable and cost-effective delivery

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0030] figure 1 and Figure 2 shows a nasal delivery device according to a first embodiment of the present invention.

[0031] The nasal delivery device comprises a housing 15, a nosepiece 17 for fitting into the nasal cavity of a subject, a mouthpiece 19 through which the subject exhales in use, and a substance supply unit 21 comprising An actuator 23 extending from one end of 15 and the substance supply unit 21 is manually operated to deliver the substance to the nasal cavity of the subject.

[0032] The housing 15 comprises a main body section 25, which in this embodiment is an elongated section, from a base end of which the actuating member 23 of the substance supply unit 21 extends.

[0033] The housing 15 further includes a handle section 27 arranged at one end of the main body section 25 .

[0034] The handle section 27 comprises a distal first portion 28 and a proximal second portion 31, the distal first portion 28 comprising at least one protruding handle element 29...

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PUM

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Abstract

A nasal delivery device comprising: a housing (15); a nosepiece (17) for fitting to a nasal cavity of a subject; a mouthpiece (19) through which the subject in use exhales; and a substance supply unit (21) including an actuation member (23) which extends from one end of the housing and is manually actuated to deliver substance to the nasal cavity of the subject; wherein the housing includes a grip section (27) which is disposed at the one end of the housing from which the actuation member extends, said grip section comprising a first, distal part (28) including at least one projecting grip element (29) by which the subject grips the housing in actuating the actuation member, and a second, proximal part (31) providing a recess (33) in which fingers of the subject are located, said recess promoting proper orientation of the delivery device in a hand of the subject.

Description

technical field [0001] The present invention relates to nasal delivery devices and methods for delivering substances, especially liquids in the form of suspensions or solutions, or powders containing medicaments, especially systemic or topical medicaments, to the nasal airways of a subject, or vaccines. Background technique [0002] see Figure 5 , the nasal airway 1 includes two nasal cavities separated by the nasal septum, wherein the nasal airway 1 includes multiple ostia such as sinus ostia 3 and lacrimal duct ostia 5 and olfactory cells and is lined with nasal mucosa. The nasal airway 1 can communicate with the nasopharynx 7 , the oral cavity 9 and the lower airway 11 , wherein the nasal airway 1 selectively communicates with the front region of the nasopharynx 7 and the oral cavity 9 through the opening and closing of the oropharyngeal membrane 13 . The membrane 13, also commonly called the soft palate, is shown in solid lines in the closed position, which can be achi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M15/08
CPCA61M15/08A61M2205/586A61M2210/0618A61M2210/0625A61M2202/04A61M2202/064A61M15/0021
Inventor P·G·杰佩斯兰德K·达吉恩J·戈登M·瓜拉雅M·勒克莱尔R·A·马莫德
Owner OPTINOSE INC