Application of sivelestat as medicine for treating epilepsy

A technology for sivelestat and epilepsy, which is applied in the field of drug application to achieve the effect of improving curative effect

Inactive Publication Date: 2015-04-01
李亚军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether sivelestat has a protective effect on brain tissue damage caused by epilepsy has not been reported at home and abroad.

Method used

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  • Application of sivelestat as medicine for treating epilepsy
  • Application of sivelestat as medicine for treating epilepsy
  • Application of sivelestat as medicine for treating epilepsy

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Experimental program
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Embodiment Construction

[0022] The present invention will be described in detail below in combination with specific embodiments.

[0023] The present invention relates to the application of sivelestat as a medicine for treating epilepsy, the dosage of sivelestat is 10 mg / kg, which can inhibit the expression of high mobility group box 1 and neutrophil elastase, prevent high The migration of mobility group protein 1 reduces the inflammatory response of damaged brain cells, reduces the content of serum S100β, and protects the blood-brain barrier, thus playing the role of anti-inflammation and anti-epilepsy, which can indirectly reduce the number of damaged neurons and play a role to protect brain neurons.

[0024] Experiments that sivelestat has anti-inflammatory response, anti-epilepsy, blood-brain barrier protection and brain neuron protection:

[0025] Materials and methods:

[0026] 1.1 Experimental animals

[0027] 110 healthy adult male Sprague-Dawley (SD) rats (5-6 weeks after birth, body weig...

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Abstract

The invention relates to application of sivelestat as a medicine for treating epilepsy. The sivelestat can be used for reducing inflammatory media and protecting neuron, and but, whether the sivelestat can be used for protecting brain tissue injury caused by epilepsy or not cannot be reported at home and abroad currently. The invention provides an application of the sivelestat as the medicine for treating epilepsy; the sivelestat can be used as an anti-inflammatory and anti-epilepsy medicine by inhibiting expression of high-mobility group protein 1 and neutrophil elastase, stopping mobility of the high-mobility group protein 1, reducing injured brain cell inflammatory response and reducing the content of serum S100 beta; and the sivelestat can form a barrier for protecting blood brain, and has the effects of reducing epilepsy inflammatory response, reducing the number of injured hippocampal neurons and protecting injured cerebral neuron.

Description

technical field [0001] The invention relates to a drug application, in particular to the application of sivelestat as a drug for treating epilepsy. Background technique [0002] Epilepsy (Epilepsy) is a brain disorder characterized by a persistent epileptogenic tendency and corresponding neurobiological, cognitive, and psychosocial consequences. Epilepsy is a common disease of the nervous system. In recent years, the incidence of epilepsy has been increasing year by year worldwide. It has affected about 50 million people in the world. The etiology and pathogenesis of epilepsy are very complicated. With the progress of epilepsy research , There have been methods for the treatment of epilepsy including drugs, surgery, vagus nerve stimulation, and deep brain electrical stimulation, and the curative effect of epilepsy has been improved to a certain extent. There are many treatment methods for epilepsy, and early, sufficient, and individualized drug therapy is still the most im...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K31/222A61P25/08
CPCA61K31/222
Inventor李亚军王林
Owner李亚军