Medicinal use of gilt-edged leech

A technology of Phnom Penh leech and medicine, which is applied in the field of traditional Chinese medicine powder---Phnom Penh leech powder, which can solve problems such as gout that has not been treated

Inactive Publication Date: 2015-04-15
广西卫生职业技术学院
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Medicinal use of gilt-edged leech
  • Medicinal use of gilt-edged leech
  • Medicinal use of gilt-edged leech

Examples

Experimental program
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Effect test

Embodiment 1

[0008] Example 1 Extraction of Phnom Penh Leech Powder: 1000g of Phnom Penh Leech is freeze-dried and processed.

Embodiment 2

[0009] Acute toxicity study of embodiment 2 Phnom Penh leech powder

[0010] 40 healthy adult mice were selected, observed for 3 days, and then randomly divided into two groups, namely the normal control group (given with equal volume of distilled water) and the Phnom Penh leech group, with 20 mice in each group, half male and half male. The maximum concentration and maximum volume of Phnom Penh leeches were given by intragastric administration, and then observed for 14 days. The diet, body weight, toxicity symptoms (including appearance behavior, secretions, excretions, etc.) and death of the mice were observed. After 14 days, the mice were sacrificed, and the mice were dissected to observe the state of the main organs.

[0011] 10 minutes after intragastric administration, the mice in the control group and Phnom Penh leech group showed abnormalities. Within 14 days, no death occurred in all mice, and there was no abnormality in diet, appearance, behavior, secretions, and ex...

Embodiment 3

[0012] Embodiment 3 Phnom Penh leeches influence on uric acid level

[0013] Effect of Phnom Penh Leech on Uric Acid in Hyperuricemia Mice

[0014] Select 60 Kunming mice weighing 18-22 g, half male and half male, and randomly divide them into 6 groups, 10 mice in each group, namely normal control group, model group, positive drug allopurinol tablet (50 mg / kg) group, Phnom Penh leech High, medium and low (3.00g herbs.kg -1 , 1.50g herbs.kg -1 , 0.75g herbs.kg -1 ) dose group. Oral administration, once a day, the normal control group and the model group were given equal volume of distilled water by intragastric administration for 12 consecutive days. Hypoxanthine 10 mg / kg was intraperitoneally injected 1 hour after the last administration, blood was collected from the eyeball 1 hour later, centrifuged at 3000 rpm for 10 minutes, and the supernatant was taken to measure the serum uric acid content.

[0015] The experimental results showed that, compared with the normal cont...

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Abstract

The invention relates to a new use of gilt-edged leech in gout prevention and treatment. Researches find that the gilt-edged leech has strong gout resistance, 1.50g medicine/kg can substantially reduce the level in uric acid in serum of a hyperuricemia mouse, 3.00g medicine/kg and 1.50 medicine/kg respectively substantially reduce the level of uric acid in the serum of a normal mouse, and the medicine can substantially inhibit toe swelling induced by sodium urate, has a pain easing effect and has small toxic side effects. The maximal tolerance dose of mice gavaged with gilt-edged leech powder is 23.09g medicine/kg body weight. The medicine can be used to prepare oral gout resistant medicines and health products.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine powder---Phnom Penh leech powder, which is proved to have new medical application through pharmacological experiments. Specifically, Phnom Penh leech powder can significantly inhibit the generation of blood uric acid in hyperuricemia mice, significantly reduce the blood uric acid level of normal mice; can significantly inhibit the toe swelling induced by sodium urate, has an analgesic effect, and has little toxic side effects. The maximum tolerated dose of Phnom Penh leech powder in mice was 23.09g medicinal material / kg body weight. It belongs to the field of traditional Chinese medicine. Background technique [0002] Gout (gout) is an ancient disease. The word gout originated from the Latin drop (gutta), which is a synonym for foot pain (podagra) in ancient medicine. , Malignant humors in weakened joints. Modern medicine believes that gout is a metabolic disease characterized by abnormal purin...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61P19/06
Inventor 刘喜华张柯媛黄敏琪林忠文刘安韬
Owner 广西卫生职业技术学院
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