50 results about "Sodium urate" patented technology

The invention relates to an oral medicinal combination and the preparing method, using Epimedium Herb, Coix Seed, Tangerine Peel, Perilla Leaf, Common Floweringqince Fruit and other Chinese drugs as raw materials, first decocting these raw materials to extract fragrant liquid, then decocting twice and filtering, combining the filtrate, fragrant liquid and auxiliaries and making the mixture into different preparations. It can remove damp and dredge meridian, and eliminating rheumatism and stop pain, and is used to relieve joint gall of toes and metatarsi caused by gout caused by damp and corruption. In addition, the curative effect test verifies that it can prohibit joint gall of sole of the foot of a rat caused by sodium urate (MSU), remarkably reduce white cells in joint liquid of a rabit with acute arthritis induced by MSU, remarkably prohibit the foot swelling of a rat caused by carageen glue and the ear swelling of a mouse caused by dimethylbenzene, and obviously prohibit the forming of granulation swelling of a rat.

The invention discloses application of cannabinoids in the preparation of a medicine for treating gout. The inventor found for the first time that cannabinoids have a very strong antigout effect, can significantly reduce serum urate level of hyperuricemia mice but have no remarkable influence on serum urate level of normal mice, can substantially inhibit toe swelling induced by sodium urate, have more excellent activity than allopurinol and have little toxic and side effect. The invention also provides a gout-treating medicinal preparation of the cannabinoids and a corresponding dosage form. By a conventional preparation method, various different dosage forms of medicines used in clinic can be prepared and are convenient to use.

The invention discloses disinfection powder for disinfecting hospital and aquaculture wastewater. The powder is prepared from the following components in percentage by mass: 20%-30% of potassium monopersulfate, 15%-20% of sodium dichloro isocyanurate, 25%-45% of dodecyl dimethyl benzyl ammonium chloride, 10%-15% of protochloride and 2%-5% of sodium hexametaphosphate. The compound disinfection powder has the advantages that (1) the compound disinfection powder is an oxidizing and non-oxidizing fungicide complex, and is good in sterilization effect; (2) the compound disinfection powder contains a dispersant component, is capable of stripping biological slime and is free of a dead angle in sterilization and disinfection; (3) the compound disinfection powder is low in consumption and does not generate secondary pollution; and (4) residual chlorine in discharged water does not exceed the standard.

The invention discloses a disinfectant for cleaning and disinfecting a hemodialysis machine. The disinfectant contains the following components by weight percent: 0.5%-1.0% of peracetic acid, 2.0%-5.0% of hydrogen peroxide, 0.1%-0.5% of pyridine-2-formic acid, 0.01%-0.05% of sodium citrate, 0.2%-2.0% of sodium dichloroisocyanurate, 0.05%-1.0% of sulfamic acid and the balance being water. A preparation technology of the disinfectant is simple, the disinfectant is convenient to use, the technological conditions are easy to achieve and the product stability is good.

The invention discloses a rapid detection kit of urea. The rapid detection kit comprises a reagent I, a reagent II, a reagent III and a reagent IV, wherein the reagent I comprises EDTA disodium and trehalose; the reagent II is urease; the reagent III comprises anhydrous citric acid, sodium salicylate and sodium nitroprusside; the reagent IV comprises lithium hydroxide, dichlord isocyanurice acid and anhydrous sodium sulfate. According to the detection kit and a detection method, the interference of copper ions and residual chlorine in water of a swimming pool to a detection result can be effectively shielded, the measuring range is 0.5mg/L-8.0mg/L, the detection time is about 20 minutes, and the guarantee periods of the reagents at the room temperature are long; the kit is high in accuracy, strong in specificity, good in stability, convenient, and rapid and is applicable to the spot rapid detection of the swimming pool, and the detection result is close to that by adopting a national standard method, so that the kit has a good application prospect.

The invention provides repairing aloe essence which comprises barbaloin, water, methylparaben, propylparaben, sodium urate and vitamin E, wherein the barbaloin is 100% pure natural aloe essence extracted from aloe in freezing state. The repairing aloe essence disclosed by the invention realizes the repairing and rapid moisturizing effects through micromolecule with high seepage velocity, has certain repairing effect and certain curative effect on sunburned skin and skin diseases respectively, and normalizes the skin functions; as the relieving tenderness of the aloe, the repairing aloe essence is suitable for sensitive, dry, mixed and oily skin.

The invention discloses application of sunflower small molecule peptide in reduction of uric acid, dissolving of uratoma and repairing of a renal function. According to the application of sunflower small molecule peptide in preparation of drugs for reduction of uric acid, dissolving of uratoma and repairing of the renal function, the sunflower small molecule peptide can have effects of diminishinginflammation, subduing swelling, stopping pain and reducing blood uric acid, and dissolving sodium urate, meanwhile, good effect of repairing injured cells of the kidneys is achieved, the sunflower small molecule peptide has effect of treating both symptoms and root causes of hyperuricosuria, and thus, the hyperuricosuria can be treated fundamentally.

The invention discloses a strong oxidizability pipeline dredging agent, which comprises a main material and an auxiliary material, the main material comprises the following raw materials by weight: 60-80 parts of sodium hydroxide, 10-30 parts of sodium dichloroisocyanurate, or 10-30 parts of sodium trichloroisocyanurate, or 10-30 parts of sodium hypochlorite; the auxiliary materials comprise the following raw materials in parts by weight: 5-15 parts of sodium carbonate, 5-15 parts of sodium sulfate, 0.5-1 part of biological enzyme particles and 0.5-1 part of essence. The traditional formula of the pipeline dredging agent sold in the market at present is completely abandoned, strong oxide materials such as sodium dichloroisocyanurate or sodium trichloroisocyanurate or sodium hypochlorite are innovatively added, aluminum particles and sodium percarbonate are not added, and the product is mild in dredging, free of condensation, choking and hurting people, high in dissolving capacity and wider in dredging range, has disinfection and sterilization effects and is suitable for popularization and application. Viruses are effectively killed, a sewer infection chain is cut off, and epidemic situation spreading channels are reduced.

The invention relates to a novel purpose of a Polyrhachis vicina Roger alcohol extract and an aqueous extract for preventing and treating gout. The research shows that the Polyrhachis vicina Roger alcohol extract or the aqueous extract possesses strong anti-gout effect, the alcohol extract (4g crude drug/kg, 2g crude drug/kg) and the aqueous extract (4g crude drug/kg) substantially reduce the hyperuricemia mice serum uric acid level, have no substantial influence on normal mice serum uric acid level, and can substantially inhibit the toe swelling induced by sodium urate, the activity and allopurinol are equal, and the toxic and side effect are small. Mice take Polyrhachis vicina Roger alcohol extract LD50 is 54.64g crude drug/kg, 95% of reliability of LD50 is 48.36 crude drug/kg-61.73 crude drug/kg; mice take Polyrhachis vicina Roger aqueous extract LD50 is 69.82g crude drug/kg, 95% of reliability of LD50 is 66.73 crude drug/kg-73.04 crude drug/kg. The Polyrhachis vicina Roger extract can be used for preparing anti-gout medicines and health products.

The invention relates to the field of natural medicaments, in particular to application of a philippine violet herb total phenol extract to treatment of hyperuricacidemia. Pharmacological tests prove that joint swelling of gouty arthritis of rats due to sodium urate crystals can be relieved obviously and the tread treatment of the rats can be improved by intragastric administration of the philippine violet herb total phenol extract. The philippine violet herb total phenol extract has the obvious inhibitory effect on hyperuricemia and urate nephropathy of mice due to a uricase inhibitor, adenine and ethambutol, but does not exert obvious influence on urinary volume, so the philippine violet herb total phenol extract has the effect of promoting the excretion of uric acid and has no effect of diuresis; and due to the single function of the philippine violet herb total phenol extract, doctors do not need to consider the influence of diuretic factors on patients during clinical application.

The invention discloses a special additive for raw material culture of pleurotus ostreatus and coprinus comatus. A formula comprises an A component and a B component, wherein the A component comprises 1000g of raw gypsum, 1000g of calcium superphosphate, 1000g of urea, 10g of 4.5% high-effect cypermethrin emulsifiable concentrate and 5g of 50% phoxim emulsifiable concentrate; and the B component comprises 30g of magnesium sulfate, 0.042g of ferrous sulfate heptahydrate, 0.027g of manganese sulfate, 0.017g of zinc sulfate, 0.001g of copper sulfate, 0.013g of sodium tetraborate, 0.0025g of ammonium molybdate, 50g of sodium dichloroisocyanurate and 50g of sodium sulfate. The formula of a culture medium, disclosed by the invention, has obvious insect prevention and insect killing effects, and can ensure that insect pests can be basically avoided during hyphae period and fruiting period; a sterilization scheme based on the sodium dichloroisocyanurate is adopted, and the whole sterilization process can be always prevented from being polluted by mixed bacteria; the matching is reasonable.

The invention discloses an application of cannabidiol in preparing medicines for treating gout. The inventor discovers that cannabidiol has a quite strong gout resisting effect for the first time, and the cannabidiol is capable of significantly reducing the serum uric acid level of a mouse with hyperuricemia, avoiding obvious influence on the serum uric acid level of a normal mouse and significantly reducing and inhibiting swelling toes caused by sodium urate; the activity of the cannabidiol is better than that of allopurinol; and the cannabidiol is low in toxic and side effects. The invention also provides a pharmaceutical preparation of the cannabidiol for treating the gout and a corresponding dosage form of the pharmaceutical preparation; and by virtue of a conventional preparation method, the cannabidiol can be prepared into clinically applicable medicines in various dosage forms, and the medicines are convenient to use.

The invention discloses an application of industrial hemp cannaboid in preparing gout treating medicines. The inventor, for the first time, discovers that the cannaboid, prepared from industrial hemp, can significantly reduce a serum uric acid level in a mouse with hyperuricemia while has no obvious influence on a serum uric acid level in a normal mouse; the cannaboid can significantly inhibit sodium urate induced toe swelling; and the cannaboid is equivalent to allopurinol in activity and and the cannaboid is low in toxic and side effects. The cannaboid has a concrete effect of preventing and treating gout. The invention also provides a pharmaceutical preparation of the industrial hemp cannaboid for treating the gout as well as a corresponding pharmaceutical dosage form of the pharmaceutical preparation; clinically available medicines differing in dosage forms can be prepared by virtue of a conventional preparation method; and the medicines are convenient to use.

The invention provides an application of salidroside in preparation of a medicine for resisting gouty arthritis, and particularly relates to prevention and curing functions of salidroside on acute gouty arthritis. The salidroside has the benefits as follows: the salidroside has prevention and curing functions on gouty arthritis, especially acute gouty arthritis. The animal experiment proves that sodium urate induced acute gouty arthritis can really be relieved by the salidroside. Therefore, when the salidroside is applied to preparation of the medicine for resisting gouty arthritis, one natural or natural-like medicine can be provided for treatment of gouty arthritis, and adverse effects caused by the medicine for treating gouty arthritis are reduced.

The invention discloses a method for generating myeloid suppressor cells through sodium urate induction. The method comprises the following steps: (1) separating mononuclear cells from a sample; (2) carrying out in-vitro culture on the monocytes obtained in the step (1) by using a complete culture medium containing GM-CSF; and (3) adding sodium urate into the culture system in the step (2), and continuously carrying out in-vitro culture to obtain the myeloid suppressor cells. The method is safe and simple, the myeloid suppressor cells with the immunosuppressive function can be generated through rapid induction, and the myeloid suppressor cells prepared through the method can be used for treating autoimmune diseases, neoplastic diseases and the like and have good application prospects.

The invention relates to the field of medicine, and particularly provides application of cobra venom or an extract thereof to preparation of a medicament for reducing uric acid and/or resisting to gouty arthritis. According to the invention, the cobra venom can effectively reduce the blood uric acid level of a hyperuricemic mouse, meanwhile, has an obvious improvement effect on the gouty arthritis, and can repair the joint injury caused by sodium urate deposition, reduce the joint swelling rate, improve the joint synovial tissue thickening condition, reduce inflammatory cell infiltration, protect cartilage cells; and clinical experiments show that cobra neurotoxin can quickly eliminate subcutaneous gout calculi of gout patients, lumps disappear after the cobra venom is injected into the patients for three days, and no side effect exists. In conclusion, the Chinese cobra venom has the effect of repairing gouty arthritis while reducing uric acid, and can be used as a medicament for treating gout.

The invention discloses an application of capsaicine in inhibition of activation of NLRP3 inflammasome. Researches find that capsaicin can inhibit activation of different agonists such as nigericin, microcrystalline sodium urate and alum on NLRP3 inflammasomes, but does not affect activation of inflammasomes such as NLRC4 and AIM2, and can also inhibit assembly of the NLRP3 inflammasomes, including combination of NLRP3 and ASC protein and formation of ASC spots. In addition, the invention also finds that capsaicine can inhibit lipopolysaccharide-induced septicemia. Therefore, the capsaicine can be used as an NLRP3 inflammasome activation inhibitor and a potential medicine for preventing or treating diseases related to abnormal activation of NLRP3 inflammasome.

The invention relates to application of a compound in preparation of a drug for treating gout. The compound has a structure as shown in formula I. Through experiments, it shows that the compound can inhibit URAT1, reabsorption of uric acid is stopped, discharge of the uric acid of rats can be promoted, the serum urate levels is reduced, sodium urate induced THP-1 CELL IL-1 beta and TNF-alpha secretion can further be inhibited obviously, the degree of rat ankle swelling caused by sodium urate is reduced, inflammatory response is reduced, and arthralgia is relieved. It shows that the compound has effect of treating hyperuricemia and/or gout and has high application value.

The invention discloses an ixeris sonchifolia hance preparation with an anti-gout effect. Through the anti-gout effect of the ixeris sonchifolia hance preparation, the clinical indication of ixeris sonchifolia hance is increased, so that the ixeris sonchifolia hance preparation not only can be used for treating a coronary heart disease, cerebral thrombosis, angina pectoris, anti-tumor and the like, but also can be used for treating a gout disease. An ixeris sonchifolia hance extract is taken orally and by injection, has an obvious effect on a hyperuricemia model induced by sodium urate in miceand is close to an allopurinol positive control group in effect. The ixeris sonchifolia hance preparation disclosed by the invention has the benefits that the ixeris sonchifolia hance preparation isa pure traditional Chinese medicine preparation, is small in toxic and/or side effects, has a cardiovascular and cerebrovascular protection effect and is an ideal anti-gout drug.

The invention relates to a new use of gilt-edged leech in gout prevention and treatment. Researches find that the gilt-edged leech has strong gout resistance, 1.50g medicine/kg can substantially reduce the level in uric acid in serum of a hyperuricemia mouse, 3.00g medicine/kg and 1.50 medicine/kg respectively substantially reduce the level of uric acid in the serum of a normal mouse, and the medicine can substantially inhibit toe swelling induced by sodium urate, has a pain easing effect and has small toxic side effects. The maximal tolerance dose of mice gavaged with gilt-edged leech powder is 23.09g medicine/kg body weight. The medicine can be used to prepare oral gout resistant medicines and health products.

The invention relates to a solid chlorine disinfectant, and a preparation method and application thereof. The solid chlorine disinfectant is prepared from, by mass, 60-80% of trichloroisocyanuric acid, 5-15% of sodium dichloroisocyanurate, 3-8% of bromochlorohydantoin, 0.02-0.08% of hydroxymethyl cellulose, 0.5-1.5% of boric acid, 0.6-1.2% of chlorinated trisodium phosphate, 5-15% of anhydrous sodium sulfate, 3-8% of trisodium phosphate and 0.2-0.6% of citric acid. The solid chlorine disinfectant can be used as a slow-release disinfectant. Compared with the prior art, the solid chlorine disinfectant has efficient, stable and broad-spectrum disinfection and sterilization effects, is wide in application range, and can be applied to disinfection of closed environment spaces, hard object surfaces, swimming pool water, hospital sewage and the like.

The invention belongs to the technical field of biological medicine, and particularly relates to application of folium artemisiae argyi volatile oil to inhibition of activation of NLRP3 inflammasomes.The invention discloses application of the folium artemisiae argyi volatile oil to inhibition of activation of NLRP3 inflammasomes in a Nigericin and monosodium urate induced THP-1 cell inflammationmodel. Researches show that the folium artemisiae argyi volatile oil can inhibit activation of agonists with different attributes such as nigericin and mono sodium urate (MSU) on the NLRP3 inflammasomes, which is mainly manifested in inhibiting NLRP3 expression, ASC oligomer formation, cleavage activation of procaspase1, and the like, so that generation of inflammatory cytokines IL-l-beta, IL18 and TNF-alpha is inhibited, and finally an anti-inflammatory effect is achieved. Therefore, the folium artemisiae argyi volatile oil can be used as a medicine or compound medicine component for preventing or treating NLRP3 inflammasome related inflammatory diseases.

The invention relates to an anti-gout broadleaf holly leaf preparation and a preparation method and application thereof. The broadleaf holly leaf is fragrant with a bitter taste, and then sweet and cool, and has the effects of clearing heat and relieving summer heat, improving eyesight and intelligence, achieving dieresis and strengthening the heart, wetting the whistle and relieving a cough, lowering blood pressure and losing weight, resisting and preventing cancer, resisting aging and activating blood circulation and can also be used for treating gout diseases. Oral administration and injection of an extract have an obvious effect on a hyperuricemia model of mice caused by sodium urate, and are close to a positive control group of allopurinol. The anti-gout broadleaf holly leaf preparation has small toxic and side effects due to the fact that the anti-gout broadleaf holly leaf is homologous in drugs and food. At the same time, the preparation has cardiovascular and cerebrovascular protection and anti-inflammatory effects, and is an ideal anti-gout drug.

The invention provides application of flos carthami parasite in preparing a drug or a healthcare product preventing and treating gout. By inspecting the influence of flos carthami parasite extract onthe ankle joint swelling degree, the activity of serum uric acid and xanthine oxidase and the contents of serum IL-1 beta, IL-8 and TNF-a of a rat with acute gouty arthritis of a sodium urate induction injury, and by inspecting the influence of the flos carthami parasite extract on the human umbilical veins endothelial cell activity, the contents of cell supernatant, ICAM-1 and IL-1 beta, the activity of XOD and the expression amount of XOD mRNA in the cells of the sodium urate induction injury, it is found that the flos carthami parasite extract has the pharmacologic action of relieving goutfor the first time.