Application of capsaicine in inhibition of activation of NLRP3 inflammasome

A technology of inflammasome and capsaicin, applied in the direction of anti-inflammatory agents, organic active ingredients, non-central pain relievers, etc., can solve the problems that have not been reported in research, and achieve the effect of high biological safety
CN112716928AActive Publication Date: 2021-04-30SOUTH CHINA UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SOUTH CHINA UNIV OF TECH
Publication Date
2021-04-30

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Abstract

The invention discloses an application of capsaicine in inhibition of activation of NLRP3 inflammasome. Researches find that capsaicin can inhibit activation of different agonists such as nigericin, microcrystalline sodium urate and alum on NLRP3 inflammasomes, but does not affect activation of inflammasomes such as NLRC4 and AIM2, and can also inhibit assembly of the NLRP3 inflammasomes, including combination of NLRP3 and ASC protein and formation of ASC spots. In addition, the invention also finds that capsaicine can inhibit lipopolysaccharide-induced septicemia. Therefore, the capsaicine can be used as an NLRP3 inflammasome activation inhibitor and a potential medicine for preventing or treating diseases related to abnormal activation of NLRP3 inflammasome.
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Description

technical field

[0001] The invention belongs to the fields of biology and medicine, and particularly relates to the application of capsaicin in inhibiting the activation of NLRP3 inflammasome. Background technique

[0002] The inflammasome is a cytoplasmic multiprotein complex composed of members of the Nod-like receptor (NLR) family and PYHIN (pyrin and HIN domain) family members, which can be activated by various pathogen-associated molecular patterns or injury-associated molecular patterns. The function of the inflammasome is to activate caspase-1, which in turn causes the maturation and secretion of pro-inflammatory cytokines interleukin (IL)-1β and IL-18, and induces pyroptosis. The NLR family protein 3 (NLRP3) inflammasome is a macromolecular multiprotein complex composed of NLRP3, the adapter protein ASC and the effector protein Caspase-1. Unlike other inflammasomes, the NLRP3 inflammasome can be activated by a variety of stimuli, including microbial components and e...

Claims

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