Novel medical purpose of Polyrhachis vicina Roger extract

Abstract

The invention relates to a novel purpose of a Polyrhachis vicina Roger alcohol extract and an aqueous extract for preventing and treating gout. The research shows that the Polyrhachis vicina Roger alcohol extract or the aqueous extract possesses strong anti-gout effect, the alcohol extract (4g crude drug / kg, 2g crude drug / kg) and the aqueous extract (4g crude drug / kg) substantially reduce the hyperuricemia mice serum uric acid level, have no substantial influence on normal mice serum uric acid level, and can substantially inhibit the toe swelling induced by sodium urate, the activity and allopurinol are equal, and the toxic and side effect are small. Mice take Polyrhachis vicina Roger alcohol extract LD50 is 54.64g crude drug / kg, 95% of reliability of LD50 is 48.36 crude drug / kg-61.73 crude drug / kg; mice take Polyrhachis vicina Roger aqueous extract LD50 is 69.82g crude drug / kg, 95% of reliability of LD50 is 66.73 crude drug / kg-73.04 crude drug / kg. The Polyrhachis vicina Roger extract can be used for preparing anti-gout medicines and health products.

Description

technical field

[0001] The invention belongs to a traditional Chinese medicine extract---the alcohol extract and the water extract of the polypteran ants, which are proved to have new medical application through pharmacological experiments. Specifically, the water extract or ethanol extract of the polypteran ants can significantly inhibit the generation of blood uric acid in mice with hyperuricemia, but has no significant effect on blood uric acid in normal mice; it can significantly inhibit the toes induced by sodium urate. Swelling, has the effect of preventing and treating gout disease; Mice are fed with the LD of the alcohol extract of P. 50 54.64g crude drug / kg, LD 50 The 95% credible limit is 48.36 crude drugs / kg-61.73 crude drugs / kg; the LD of the water extract of P. 50 Respectively 69.82g crude drug / kg, LD 50 The 95% credible limit is 66.73 crude drug / kg-73.04 crude drug / kg. Good security. It belongs to the field of traditional Chinese medicine. Background techn...

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