Novel medical purpose of Polyrhachis vicina Roger extract

A technique of imitating polypterous ants and extracts, which is applied in the field of traditional Chinese medicine extracts, and can solve problems such as unseen treatment of gout

Active Publication Date: 2012-07-11
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Novel medical purpose of Polyrhachis vicina Roger extract
  • Novel medical purpose of Polyrhachis vicina Roger extract
  • Novel medical purpose of Polyrhachis vicina Roger extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1 Extraction of the alcoholic extract of Polyptera spp.: 1000g of Polypteria spp. powder, add 10L of 95% ethanol, reflux extraction 3 times, each time 2h, ethanol is recovered from the extract, and concentrated into a thick paste.

Embodiment 2

[0009] Example 2 Extraction of the aqueous extract of Polypteria spp.: 1000 g of Polypteria spp. powder, add 10 L of water, boil 3 times, 2 hours each time, collect the water to form a thick paste.

Embodiment 3

[0010] Example 3 Acute Toxicity Study of Ethanol Extract and Water Extract

[0011] Take mice, 18-22g, 100, and randomly divide them into 10 groups, 10 in each group, half female and half male, respectively, orally administer the alcohol extract and water extract of P. The ratio of 1:0.80 was used for the test after diluting the medicine. The administration volume is 20mL / kg. Observe the acute toxic reaction and death of animals after administration, observe continuously for 14 days, and carry out autopsy on dead animals, and calculate LD by Bliss method 50 .

[0012] After intragastric administration of the alcohol extract and water extract of Polyptera spp., the animal convulsions and hind limb stretching were seen in correlation with the dose, and some animals in the high-dose group died 30 minutes after the administration. The dead animals were dissected, and the heart, liver, spleen, lung, kidney and other organs were observed with naked eyes, and no obvious pathologic...

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Abstract

The invention relates to a novel purpose of a Polyrhachis vicina Roger alcohol extract and an aqueous extract for preventing and treating gout. The research shows that the Polyrhachis vicina Roger alcohol extract or the aqueous extract possesses strong anti-gout effect, the alcohol extract (4g crude drug/kg, 2g crude drug/kg) and the aqueous extract (4g crude drug/kg) substantially reduce the hyperuricemia mice serum uric acid level, have no substantial influence on normal mice serum uric acid level, and can substantially inhibit the toe swelling induced by sodium urate, the activity and allopurinol are equal, and the toxic and side effect are small. Mice take Polyrhachis vicina Roger alcohol extract LD50 is 54.64g crude drug/kg, 95% of reliability of LD50 is 48.36 crude drug/kg-61.73 crude drug/kg; mice take Polyrhachis vicina Roger aqueous extract LD50 is 69.82g crude drug/kg, 95% of reliability of LD50 is 66.73 crude drug/kg-73.04 crude drug/kg. The Polyrhachis vicina Roger extract can be used for preparing anti-gout medicines and health products.

Description

technical field [0001] The invention belongs to a traditional Chinese medicine extract---the alcohol extract and the water extract of the polypteran ants, which are proved to have new medical application through pharmacological experiments. Specifically, the water extract or ethanol extract of the polypteran ants can significantly inhibit the generation of blood uric acid in mice with hyperuricemia, but has no significant effect on blood uric acid in normal mice; it can significantly inhibit the toes induced by sodium urate. Swelling, has the effect of preventing and treating gout disease; Mice are fed with the LD of the alcohol extract of P. 50 54.64g crude drug / kg, LD 50 The 95% credible limit is 48.36 crude drugs / kg-61.73 crude drugs / kg; the LD of the water extract of P. 50 Respectively 69.82g crude drug / kg, LD 50 The 95% credible limit is 66.73 crude drug / kg-73.04 crude drug / kg. Good security. It belongs to the field of traditional Chinese medicine. Background techn...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P19/06
Inventor 韦桂宁牙启康曾宪彪韦宝伟
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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