Application of cannabinoids in preparation of medicine for treating gout

A cannabidiol and compound technology, applied in the field of cannabidiol compounds, can solve the problems of inability to use for a long time, large side effects, low drug efficacy, etc., and achieve the effects of less toxic and side effects, lowering serum uric acid level, and strong anti-gout effect.

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor curative effect and large side effects have become the bottleneck of its clinical application, and it cannot be used for a long ti...

Method used

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  • Application of cannabinoids in preparation of medicine for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Take cannabis flowers and leaves, after impurity removal, drying and crushing, CO2 super-extraction, ethanol redissolution after desolvation and impurity removal, pentane elution of the solution after chromatographic separation, collection of eluent, and concentration under reduced pressure , vacuum-dried and pulverized to obtain cannabinoids.

[0042] Get 100 grams of cannabinoids (through a 80-mesh sieve), add 60 grams of microcrystalline cellulose, pass through an 80-mesh sieve three times, mix well, spray 95% ethanol solution, make a soft material, pass through a 40-mesh sieve to granulate, Dry at 60°C for half an hour, pack in 3# capsules, and pack in aluminum-plastic composite to make capsules.

Embodiment 2

[0044] Take the mixture of cannabis flowers, leaves, and hemp bran, remove impurities, dry, and pulverize, then extract with CO2, remove impurities, and redissolve in ethanol. The solution is separated by chromatography and eluted with pentane. liquid, concentrated under reduced pressure, dried in vacuo, and pulverized to obtain cannabinoids.

[0045] The cannabinol compound powder is taken, 5-20% of dry starch and 1-5% of magnesium stearate are added, mixed, granulated, dried and compressed to form tablets.

Embodiment 3

[0047] Repeat Example 2, with the following differences: take the cannabinoid compound powder, add sucrose water and a conventional amount of preservatives, stabilizers and other auxiliary materials. Filter, sterilize, and divide into 10mL bottles to make oral liquid.

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Abstract

The invention discloses application of cannabinoids in the preparation of a medicine for treating gout. The inventor found for the first time that cannabinoids have a very strong antigout effect, can significantly reduce serum urate level of hyperuricemia mice but have no remarkable influence on serum urate level of normal mice, can substantially inhibit toe swelling induced by sodium urate, have more excellent activity than allopurinol and have little toxic and side effect. The invention also provides a gout-treating medicinal preparation of the cannabinoids and a corresponding dosage form. By a conventional preparation method, various different dosage forms of medicines used in clinic can be prepared and are convenient to use.

Description

technical field [0001] The present invention relates to the new application of cannabinol compounds extracted from cannabis in medicine, in particular to the application of cannabinol compounds in the preparation of medicines for treating gout. Background technique [0002] Gout is a kind of disease caused by the disorder of purine metabolism in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion is decreased, whic...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61K31/352A61K31/05A61K31/192A61K36/60A61P19/06
CPCA61K31/353A61K31/05A61K31/192A61K31/352A61K2236/37A61K2300/00
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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