Application of industrial hemp cannaboid in preparing gout treating medicines

A technology of industrial hemp and hemp, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of long-term use, large side effects, and poor curative effect, and achieve the purpose of inhibiting toe swelling, less toxic side effects, and strong anti-inflammatory effects. The effect of gout action

Inactive Publication Date: 2017-02-15
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor curative effect and large side effects have become the bottleneck of its clinical application, and it cannot be used for a long time
There are also some Chinese patent medicine preparations commonly used in the market to treat tongfeng, but the efficacy is relatively low.

Method used

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  • Application of industrial hemp cannaboid in preparing gout treating medicines
  • Application of industrial hemp cannaboid in preparing gout treating medicines
  • Application of industrial hemp cannaboid in preparing gout treating medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The flowers, leaves and hemp bran of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Mix flowers, leaves, and hemp bran in a mass ratio of 1:3:2, then dry, remove impurities, and crush to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned crushed industrial hemp raw materials into supercritical carbon dioxide In the extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure is 25-35Mpa, the carbon dioxide flow rate is 40kg / h, and the extract is collected at the outlet of the separation kettle; % (V / V) ethanol for elution, the number of elutions is 1 to 3 times; the eluate is collected, concentrated under reduced pressure, dried in vacuo, and pulverized to obtain the cannabinoid of industrial hemp.

Embodiment 2

[0028] Repeat embodiment 1, have the following difference: get the flower of industrial hemp, leaf, the mixture of hemp bran 1:1:1 mass ratio as the extraction raw material of industrial hemp cannabinoid.

Embodiment 3

[0030] Repeat embodiment 1, have following difference: get the flower of industrial hemp, leaf, the mixture of hemp bran 3:2:1 mass ratio as the extraction raw material of industrial hemp cannabinoid.

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Abstract

The invention discloses an application of industrial hemp cannaboid in preparing gout treating medicines. The inventor, for the first time, discovers that the cannaboid, prepared from industrial hemp, can significantly reduce a serum uric acid level in a mouse with hyperuricemia while has no obvious influence on a serum uric acid level in a normal mouse; the cannaboid can significantly inhibit sodium urate induced toe swelling; and the cannaboid is equivalent to allopurinol in activity and and the cannaboid is low in toxic and side effects. The cannaboid has a concrete effect of preventing and treating gout. The invention also provides a pharmaceutical preparation of the industrial hemp cannaboid for treating the gout as well as a corresponding pharmaceutical dosage form of the pharmaceutical preparation; clinically available medicines differing in dosage forms can be prepared by virtue of a conventional preparation method; and the medicines are convenient to use.

Description

technical field [0001] The invention relates to the new application of cannabis in medicine, in particular to the application of a kind of industrial hemp cannabinoid in the preparation of medicine for treating gout. Background technique [0002] Gout is a kind of disease caused by the disorder of purine metabolism in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion is decreased, which can cause hyperuricemia. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/60A61P19/06
CPCA61K36/60A61K2236/333A61K2236/37
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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