35 results about "Toe swelling" patented technology

The invention discloses application of cannabinoids in the preparation of a medicine for treating gout. The inventor found for the first time that cannabinoids have a very strong antigout effect, can significantly reduce serum urate level of hyperuricemia mice but have no remarkable influence on serum urate level of normal mice, can substantially inhibit toe swelling induced by sodium urate, have more excellent activity than allopurinol and have little toxic and side effect. The invention also provides a gout-treating medicinal preparation of the cannabinoids and a corresponding dosage form. By a conventional preparation method, various different dosage forms of medicines used in clinic can be prepared and are convenient to use.

The invention discloses a medicinal and edible composition capable of improving the immunity and a preparation method of the medicinal and edible composition. The composition is composed of the medicinal and edible medicinal materials including wheat seedlings, radix ginseng, arillus longan, mulberries, semen sesami nigrum, rhizoma polygonati and the like, as well as fructooligosaccharide and galactooligosaccharide, the integral regulation advantages of the compound traditional Chinese medicine are exerted, the effect of improving the immune functions is obvious, and the experiment proves that the medicinal and edible composition can reduce the toe swelling thickness of normal mice, and improve the activity of the NK cells, the level of the serum hemolysin, the number of antibody-producing cells, the carbon clearance phagocytosis index and the phagocytosis capacity for chicken erythrocytes of macrophagocytes.

The invention relates to the technical field of medicines, in particular to an application of an xanthiazone compound in preparing a drug for preventing or treating rheumatoid arthritis. A formula ofthe xanthiazone compound is shown as follows as shown in the specification. The compound significantly inhibits NO generation for RAW264.7 inflammatory cells and fibroblast-like synoviocytes stimulated by LPS (lipopolysaccharide), and has an obvious inhibiting effect on mouse ear swelling caused by dimethylbenzene and the rheumatoid arthritis induced by collagen, and an obvious swelling diminishing and anti-inflammatory effect on rat toe swelling due to inflammation caused by a Freund adjuvant; and therefore, the compound can be used for preventing and treating the rheumatoid arthritis.

The invention relates to a novel purpose of a Polyrhachis vicina Roger alcohol extract and an aqueous extract for preventing and treating gout. The research shows that the Polyrhachis vicina Roger alcohol extract or the aqueous extract possesses strong anti-gout effect, the alcohol extract (4g crude drug/kg, 2g crude drug/kg) and the aqueous extract (4g crude drug/kg) substantially reduce the hyperuricemia mice serum uric acid level, have no substantial influence on normal mice serum uric acid level, and can substantially inhibit the toe swelling induced by sodium urate, the activity and allopurinol are equal, and the toxic and side effect are small. Mice take Polyrhachis vicina Roger alcohol extract LD50 is 54.64g crude drug/kg, 95% of reliability of LD50 is 48.36 crude drug/kg-61.73 crude drug/kg; mice take Polyrhachis vicina Roger aqueous extract LD50 is 69.82g crude drug/kg, 95% of reliability of LD50 is 66.73 crude drug/kg-73.04 crude drug/kg. The Polyrhachis vicina Roger extract can be used for preparing anti-gout medicines and health products.

The invention provides preparation methods of a formulated composition and an externally used preparation thereof with the effects on alleviating pain, diminishing inflammation, destroying parasites and relieving itching for treating trichomonal vaginitis and colpomycosis. The formulated composition and externally used preparation thereof comprise the following components in contents: 20-95% of angelica sinensis extract, 1-10% of gromwell extract and 3-30% of sophora alopecuroide extract. Shown by a mouse hot plate method, a torsion pain experiment, a mouse ear swelling method caused by xylene, a rat toe swelling experiment and an anti-mildew experiment, both the composition and the externally used preparation have notable analgesic, antiphlogistic and antibacterial actions. The formulated composition and the externally used preparation provided by the invention adopt traditional Chinese medicinal materials as raw materials, have no toxic and side effects and can be used for a long term; especially, the preparation methods of externally used suppository, lotion and effervescing agent provided by the invention have simple processes and are favorable for industrialized production; the externally used preparation not only plays a local therapeutic action, but also can play a systemic therapeutic action; and shown by clinical tests, the formulated composition and the externally used preparation provided by the invention have the efficacies of alleviating pain, diminishing inflammation, destroying parasites and relieving itching, and can be used for effectively treating vaginitis.

The invention belongs to the technical field of medicine, relating to the application of an extractive obtained from leguminosae mucuna plant velvet bean on preparing anti-inflammatory analgesic drug. In the invention, the anti-inflammatory action of the velvet bean extractive on the acute inflammation models of xylene-induced mouse ear edema and carrageenin-induced mouse toe swelling is observed, and the analgesic action of the velvet bean extractive on the model of mouse pain induced by hot plate and acetic acid is also observed. Experiments prove that the extractive has the anti-inflammatory analgesic action and can be used for preparing anti-inflammatory analgesic drug preparations. The prepared drug preparation contains the velvet bean extractive and one or more pharmaceutically acceptable pharmaceutic adjuvants, wherein the velvet bean extractive accounts for 1-95 wt% of the preparation. The drug preparation formulation comprises oral liquid, granules, capsules and injections.

The invention discloses an application of industrial hemp cannaboid in preparing gout treating medicines. The inventor, for the first time, discovers that the cannaboid, prepared from industrial hemp, can significantly reduce a serum uric acid level in a mouse with hyperuricemia while has no obvious influence on a serum uric acid level in a normal mouse; the cannaboid can significantly inhibit sodium urate induced toe swelling; and the cannaboid is equivalent to allopurinol in activity and and the cannaboid is low in toxic and side effects. The cannaboid has a concrete effect of preventing and treating gout. The invention also provides a pharmaceutical preparation of the industrial hemp cannaboid for treating the gout as well as a corresponding pharmaceutical dosage form of the pharmaceutical preparation; clinically available medicines differing in dosage forms can be prepared by virtue of a conventional preparation method; and the medicines are convenient to use.

The invention relates to traditional Chinese medicine composition for treating rheumatoid arthritis and bone destruction and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from raw materials in parts by weight as follows: 10-20 parts of Japan sabia, 15-30 parts of malaytea scurfpea fruits, 15-30 parts of fortune's drynaria rhizomes, 9-15 parts of Chinese angelica and 15-20 parts of epimedium herbs. The traditional Chinese medicine composition has a remarkable inhibition function on toe swelling of a rheumatoid arthritis animal model, can remarkably reduce loss of bone mass around an inflammable joint of the rheumatoid arthritis animal model, improves the bone biomechanical parameter and inhibits bone destruction caused by rheumatoid arthritis; the traditional Chinese medicine composition has the advantages that a few raw materials are required, preparation is convenient, the cost is low, and no toxic and side effects are caused.

The invention discloses application of gymnema sylvestre schult fruits in an anti-inflammatory drug and a composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug. The composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug is characterized in that the composition contains the gymnema sylvestre schult fruits having an anti-inflammatory effect, and the gymnema sylvestre schult fruits exist in a form of gymnema sylvestre schult fruit water extract or gymnema sylvestre schult fruits and 70-percent alcohol total extract. The anti-inflammatory action of the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract is researched by using xylene, a glacial acetic acid and carrageenan as pro-inflammatory cytokines, a result shows that mouse auricle swelling reaction caused by the xylene can be inhibited by the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract, increment of mouse peritoneal vascular permeability induced by the glacial acetic acid can be reduced, mouse toe swelling caused by the carrageenan can be inhibited, an anti-inflammatory effect is obtained, fewer adverse effects exist after taking the composition, and the safety is better; an extracting method and an extracting preparation method in the invention are simple in operation and easy to understand.

The invention relates to a new use of gilt-edged leech in gout prevention and treatment. Researches find that the gilt-edged leech has strong gout resistance, 1.50g medicine/kg can substantially reduce the level in uric acid in serum of a hyperuricemia mouse, 3.00g medicine/kg and 1.50 medicine/kg respectively substantially reduce the level of uric acid in the serum of a normal mouse, and the medicine can substantially inhibit toe swelling induced by sodium urate, has a pain easing effect and has small toxic side effects. The maximal tolerance dose of mice gavaged with gilt-edged leech powder is 23.09g medicine/kg body weight. The medicine can be used to prepare oral gout resistant medicines and health products.

The invention relates to the preparation and use of parapolybia spp. insect anti-inflammatory and analgesic effective ingredients. The effective ingredients are obtained by dialyzing from coarse bee venom of parapolybia varia with a dialysis membrane which has a MWCO (Molecular Weight Cut Off) at 15 KDa; an eluate is subject to freeze drying or pressure-relief concentration drying, so that the effective ingredients are obtained. Various TTS (transdermal thrapeutic systems) of the effective ingredients can effectively increase the infrared ray hot prick threshold value of a mouse, remarkably restrain mouse toe swelling caused by albumen and mouse high blood capillary permeability caused by acetic acid, remarkably relieve arthrocele of a rat with adjuvant arthritis, and reduce cross-section diameter of arthrosis; insect polypeptide anti-inflammatory and analgesic effective ingredients and TTS are expected to be used for preparing anti-inflammatory and analgesic biochemical drugs, are used for treating acute and chronic inflammation and relieving pains before and after various operations, preventing and treating pains accompanied by cosmetology, microscopic examination and burns, and easing acute and chronic pains such as neuropathic pain and cancer pain.

The invention relates to an analgesic and anti-inflammatory active site of a Vespa insect, as well as a preparation method and application thereof. The active site is obtained by performing dialysis on crude wasp venom of a Vespa wasp by a dialysis membrane with MWCO (molecular weight cutoff) of 15KDa, and performing freeze-drying or decompression concentration drying on an eluate for preparation. A variety of percutaneous absorption preparations of the active site can effectively prolong the hot plate-stimulated pain threshold value and infrared heat tingling threshold value of mice and obviously inhibit the acetic acid-induced pain writhing response of the mice, as well as significantly inhibit xylene-induced ear edema of the mice, the egg white-induced toe swelling of the mice and the acetic acid-induced increased capillary permeability of the mice, significantly reduce the adjuvant-induced arthritis joint swelling of rats and reduce the joint circumference. The analgesic and anti-inflammatory active site of the insect and the percutaneous absorption preparations can be expected to be used for preparing anti-inflammatory and analgesic biochemical medicaments for treating acute and chronic inflammation, relieving pain before and after various operations and relieving pain and neuropathic pain accompanied by cosmetology, microscopic examination, burns and scalds, cancer pain and other acute and chronic pain.

The invention discloses a murine toe swelling tester, belonging to the technical field of pharmacological appliances. A total bearing plate is a rectangular body, a gravity pillar is arranged at one side of the upper end of the total bearing plate, the gravity pillar is connected with a measurement platform and a gravity sensor at the lower end of the total bearing plate by bolts, one end of the gravity sensor is connected with a sensor support, the other end of the gravity sensor is connected with a gravity support, and a measurement cup is placed on the upper end of the measurement platform; the other side of the upper end of the total bearing plate is connected with a stand column frame by bolts, the top end of the stand column frame is connected with an upper end plate by bolts, a lifting threaded rod is arranged at the front end of the stand column frame, the upper end of the lifting threaded rod is mounted on the upper end plate, a motor fixing plate of a rotation fixator is connected with a lifting board by a bolt through threaded holes of the lifting board, and one end of the motor fixing plate is connected with a rotation fixator motor; a detection channel is arranged on a measurement circuit board, and is electrically connected with an LM 358 direct current signal amplification module, the LM 358 direct current signal amplification module is connected with the gravity sensor, the measurement circuit board is electrically connected with an RS 232 communication port, and the RS 232 communication port is connected with a computer.

The invention discloses an application of licochalcone A in preparation of an anti-anaphylactoid drug. KU812 cell degranulation, toe swelling degree, toe Evans blue exudation degree and serum TNF-alpha release amount are compared to evaluate a to-be-detected medicine group, a normal saline control group and a normal control group, so that the treatment effect of the medicine on anaphylactoid diseases is evaluated, and the invention determines that the licochalcone A can be used for preparing the anti-anaphylactoid drug. The licochalcone A can effectively relieve local and systemic anaphylactoid reaction symptoms of mice; and the licochalcone A can reduce mast cell degranulation, and remarkably improve symptoms caused by anaphylactoid.

The invention relates to an alpine-yarrow-herb compound oral preparation and an application. The oral preparation is prepared from alpine yarrow herbs, smilax china, gallnuts, cuttlebones, coriander seeds, corals and fennelflower seeds. The alpine-yarrow-herb compound oral preparation has the obvious promoting effect on the rat in-vitro gastrointestinal smooth muscle contractile activity, has the obvious protective effect on the rat reflux esophagitis mucosa, has the obvious inhibiting effect on acute inflammation caused by mouse ear swelling induced by dimethylbenzene, subacute inflammation caused by rat toe swelling induced by carrageenan, chronic inflammation caused by rat cotton pellet granuloma and generation of inflammation mediator PGE2, and has the neutralization effect on acid indigestion. Clinical researching and experimental researching show that the alpine-yarrow-herb compound oral preparation is capable of removing local abnormal biliary fluid and blood stasis, astringing and inducing astringency, promoting digestion and descending qi, and has the remarkable treating effect on reflux esophagitis and gastritis.

The invention relates to two diclofenac zinc complexes with anti-inflammatory activity and a preparation method thereof, belonging to the technical fields of complex synthesis and medicinal chemistry. Of the two complexes provided by the present invention, complex 1 is a 6-coordinated mononuclear structure, and each complex molecule contains 2 molecules of deprotonated diclofenac, 1 molecule of tetramethylethylenediamine and a zinc ion. Complex 2 is a 6-coordinate mononuclear structure, and each complex molecule contains 2 molecules of deprotonated diclofenac, 1 molecule of 1,3‑propylenediamine and a zinc ion. After testing, it was found that the complexes 1 and 2 of the present invention achieved 52.24% ± 1.33% and 54.88% ± 5.5% respectively, and the gastric ulcer index was 4.75 ± 0.95 and 11.8 ± 2.179 respectively, and diclofenac sodium The inhibition rate to rat paw swelling is 36.08%, and the gastric ulcer index is 24.4. In contrast, the two complexes of the present invention have better anti-inflammatory activity and lower gastric side effects, and can be used to prepare anti-inflammatory drugs.

The invention belongs to the technical field of medicines, and particularly discloses application of a pennoside compound and pharmaceutically acceptable salt thereof in preparation of medicines for treating rheumatoid arthritis. In-vivo and in-vitro researches show that the pennoside compound PSVII acts on RA synovial cells to inhibit the proliferation of RA-FLS and MH7A and induce the apoptosis of the RA-FLS and MH7A. The compound can reduce the levels of serum TNF-alpha, IL-6 and IL-1beta, improve inflammatory cell infiltration, synovial hyperplasia and arthritis pathological changes of cartilage and bone erosion, relieve toe swelling, reduce the degree of ankle joint diameter swelling, and down-regulate the arthritis, thymus and spleen indexes The pennoside compound can be used for preparing medicines for treating rheumatoid arthritis.

The invention discloses the application of general anesthetic to preparation of drugs for treating gout. The general anesthetic is prepared through uniform mixing of 0.3-99.7 parts by weight of hemp fructus cannabis extract and 99.7-0.3 part by weight of hemp cannabinoid. Experiments prove that the general anesthetic has a great anti-gout effect, can remarkably reduce the level of serum uric acid of mice suffering from hyperuricemia, does not affect the level of serum uric acid of normal mice obviously, can remarkably restrain toe swelling induced by sodium urate, has activity similar to that of allopurinol, and has a small toxic or side effect. The general anesthetic has definite gout treating and preventing effects. The invention further provides a pharmaceutic preparation containing the general anesthetic for treating gout, and a corresponding dosage form. The general anesthetic can be made into clinically used drugs of various dosage forms with conventional preparing methods, and is convenient to use.

The present invention provides sennoside containing plant salt. The plant salt contains the following components: suaeda salsa extract, nostoc flagelliforme powder, rhizoma chuanxiong powder, wax gourd powder, raspberry extract, shii-take extract, and sennoside. A preparation method of the sennoside containing plant salt comprises a suaeda salsa extract preparing step. The suaeda salsa extract preparing step comprises the steps of raw material crushing, enzymatic hydrolyzing, heavy metal removing, and edible salt co-crystallizing. The beneficial effects are as follows: the plant salt has a significant swelling diminishing effect. The plant salt is used to conduct a mouse toe swelling diminishing experiment. At 6 h of the experiment, the swelling degree of the mouse toes of the mice fed by the plant salt is only 49.1-57.9% of the swelling degree of the mouse toes of the mice not fed by the plant salt. The plant salt can significantly improve patients' symptoms of morbid leucorrhoea and gonorrhea, and the improvement effective rate of the morbid leucorrhoea is 85-93% and the improvement effective rate of the gonorrhea is 92-96%. The plant salt can significantly improve patients' symptoms of dermatophytosis and the improvement effective rate of the dermatophytosis is 89%-95%.