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Application of gymnema sylvestre schult fruits in anti-inflammatory drug and composition of application of gymnema sylvestre schult fruits

An anti-inflammatory drug, the technology of Gymnema sylvestris, applied in the field of application and its application composition, to achieve the effect of protecting cells from damage, good safety, and low adverse reactions when taking it

Inactive Publication Date: 2017-02-22
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, domestic and foreign researches are only limited to the research on the leaves of Gymnema sylvestris, and there are not many research reports on its stems, but so far, there are no relevant reports on the anti-inflammatory effects of its fruit and Gymnema spp. fruit , especially the research on the chemical components of its fruit is still blank, so in order to make full use of the resources of each part of Gymnema sylvestris, it is necessary to develop the medicinal use of Gymnema syringae fruit on the basis of the existing technology

Method used

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  • Application of gymnema sylvestre schult fruits in anti-inflammatory drug and composition of application of gymnema sylvestre schult fruits
  • Application of gymnema sylvestre schult fruits in anti-inflammatory drug and composition of application of gymnema sylvestre schult fruits
  • Application of gymnema sylvestre schult fruits in anti-inflammatory drug and composition of application of gymnema sylvestre schult fruits

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Wash the Gymnema fruit and mash it into a slurry to obtain the original medicine of the Gymnema fruit. Apply the obtained original medicine directly to the inflamed wound, apply the medicine 3 times a day, and obviously improve after one week.

Embodiment 2

[0030] (1) Break the spoonful of Gymnema fruit to a particle size of 1cm, then add the top water just below the total amount of the spoonful of Gymnema fruit and soak for 60 minutes, boil for 20 minutes, then add the top water just below the total amount of the spoonful of Gymnema fruit for soaking 10 minutes, boiled for 40 minutes, then added the top water just below the total amount of the Gymnema fruit, soaked for 5 minutes, boiled for 20 minutes, cooled and filtered, took the filtrate and concentrated to a thin paste to obtain the Gymnema fruit aqueous extract.

[0031] (2) Dry the Gymnema fruit in the sun until the moisture content is 5%, and the crushed particle size is 8mm, then add the top of the total amount of Gymnema fruit just below the spoonful, and soak in ethanol with a volume concentration of 70% for 10 hours, then reflux extraction, and repeat After extracting 3 times, the extract was collected, and the obtained extract was decompressed to recover ethanol, conc...

Embodiment 3

[0034] Example 3: Evaluation of the anti-inflammatory activity of Gymnema fruit

[0035] 1. Experimental method

[0036] 1.1 Experimental animals

[0037] Kunming white mice, 22-24g, male, common grade (CV), provided by the Experimental Animal Center of Guangxi University of Traditional Chinese Medicine.

[0038] Animal feeding conditions: room temperature: 25±1°C (air-conditioning); relative humidity: 70%, free access to food and drinking water, and the feed and drinking water in each group are exactly the same.

[0039] 1.1.1 Mouse xylene-induced ear swelling experiment

[0040] 1.1.2 Grouping and administration

[0041] Male mice were taken and randomly divided into 8 groups, 8 in each group, i.e. blank control group; dexamethasone group; high, medium and low dose groups of water extract (in order: 12g crude drug / kg, 6g crude drug / kg, 3g crude drug / kg), 70% ethanol total extract high, medium and low dose groups (in order: 24g crude drug / kg, 12g crude drug / kg, 6g crude d...

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Abstract

The invention discloses application of gymnema sylvestre schult fruits in an anti-inflammatory drug and a composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug. The composition of the application of the gymnema sylvestre schult fruits in the anti-inflammatory drug is characterized in that the composition contains the gymnema sylvestre schult fruits having an anti-inflammatory effect, and the gymnema sylvestre schult fruits exist in a form of gymnema sylvestre schult fruit water extract or gymnema sylvestre schult fruits and 70-percent alcohol total extract. The anti-inflammatory action of the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract is researched by using xylene, a glacial acetic acid and carrageenan as pro-inflammatory cytokines, a result shows that mouse auricle swelling reaction caused by the xylene can be inhibited by the gymnema sylvestre schult fruit water extract and the gymnema sylvestre schult fruits and 70-percent alcohol total extract, increment of mouse peritoneal vascular permeability induced by the glacial acetic acid can be reduced, mouse toe swelling caused by the carrageenan can be inhibited, an anti-inflammatory effect is obtained, fewer adverse effects exist after taking the composition, and the safety is better; an extracting method and an extracting preparation method in the invention are simple in operation and easy to understand.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Gymnema sylvestris in anti-inflammatory drugs and its application composition. Background technique [0002] Gymnema sp. is a plant of the genus Gymnema in the family Asclepiaceae, also known as gymnasium, horn, and King Kongteng. It is widely distributed in India, Indonesia, Africa, Vietnam, and my country's Guangdong, Guangxi, Fujian, Taiwan, and Yunnan provinces. Its nature is mild. , bitter in taste, the whole plant is used as medicine, which has the effects of clearing away heat and detoxifying, promoting granulation and reducing swelling, dispelling wind and relieving pain. Modern pharmacological studies have shown that Gymnema syringae has the functions of lowering blood sugar, lowering blood fat, anti-caries, inhibiting sweet reaction, anti-virus, and anti-allergy. It has been developed into anti-diabetic drugs such as ...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61P29/00
CPCA61K36/27A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2236/53
Inventor 丘琴甄汉深姜建萍陈明伟甄丹丹丘奕定黄培倩黄小秋
Owner GUANGXI UNIV OF CHINESE MEDICINE
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