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Preparation and use of parapolybia spp. insect anti-inflammatory and analgesic effective ingredients

An effective part and wasp technology, which is applied in the field of preparation of analgesic and anti-inflammatory effective parts in the genus Heterostella vespa, can solve the problems of failure to form large-scale production capacity and low level of industrial production support, and achieve pain suppression, reduce Effects of inflammation and immune inflammatory responses

Inactive Publication Date: 2014-03-26
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with developed countries, there is still a relatively obvious gap in the research and development of my country's TTS system, especially the low level of supporting industrial production, which has not yet formed a large-scale production capacity

Method used

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  • Preparation and use of parapolybia spp. insect anti-inflammatory and analgesic effective ingredients
  • Preparation and use of parapolybia spp. insect anti-inflammatory and analgesic effective ingredients
  • Preparation and use of parapolybia spp. insect anti-inflammatory and analgesic effective ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 : Preparation of active parts of vespa heteroventrum bee venom polypeptide and film-coating agent

[0046] 1.1 Collection of crude venom from Vespa variegata:

[0047] Vespa varia varia was collected from Yingjiang County, Yunnan Province. The bee body specimen was identified as Parapolybia varia varia Fabricius by Professor Mao Benyong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province. Wasp venom collection device: use the auxiliary cover type bee venom collector modified by the engineering research center, wooden frame, 80 cm long, 50 cm wide; embedded with 4 pieces of 20 cm long / 33 cm wide poisonous glass; input voltage 6V , output automatic intermittent pulsating voltage; method of collecting wasp venom: place the poison collection device in front of the hive, and collect the poison for 20 minutes according to the routine poison collection procedure for the varieg...

Embodiment 2

[0052] Example 2 : Preparation of effective fraction of Vespa indica venom venom polypeptide and hydrogel

[0053] 2.1 Collection of crude venom from Vespa heterospica indica:

[0054] Vespa parapolybia indica was collected from Cangyuan County, Yunnan Province. The bee body specimen was identified as Parapolybia indica Saussure by Professor Yang Zizhong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province. Wasp venom collection device: use the auxiliary cover type bee venom collector modified by the engineering research center, wooden frame, 80 cm long, 50 cm wide; embedded with 4 pieces of 20 cm long / 33 cm wide poisonous glass; input voltage 6V , output automatic intermittent pulsating voltage; method of collecting vesicle venom: put the uncoated venom collector in front of the hive, collect venom for 20 minutes according to the routine venom collection procedure. Turn on the power s...

Embodiment 3

[0059] Example 3 : Preparation of poultice and film-coating agent of the active part of Vespa heteroscens bee venom polypeptide

[0060] 3.1 Collection of crude venom from Vespa heterostoria:

[0061] The vespa was collected from the territory of Menghai, Yunnan Province. The bee specimen was identified as Parapolybia indica bioculata van der Vecht (Parapolybia indica bioculata van der Vecht) . The basic device for poison collection uses a sub-cap type bee venom collector modified by the engineering research center, with a wooden frame, 80 cm long and 50 cm wide; 4 pieces of poisonous glass with a length of 20 cm / width of 33 cm are embedded; the input voltage is 9V, Output automatic intermittent pulsating voltage; The wooden frame is painted red with red paint in advance; The wooden frame is pre-smeared 20 milliliters concentration is 15 mg / ml the honeycomb and honeycomb body extract volatile solution (preparation Method: Grind 100 grams of honeycomb and 80 professional be...

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Abstract

The invention relates to the preparation and use of parapolybia spp. insect anti-inflammatory and analgesic effective ingredients. The effective ingredients are obtained by dialyzing from coarse bee venom of parapolybia varia with a dialysis membrane which has a MWCO (Molecular Weight Cut Off) at 15 KDa; an eluate is subject to freeze drying or pressure-relief concentration drying, so that the effective ingredients are obtained. Various TTS (transdermal thrapeutic systems) of the effective ingredients can effectively increase the infrared ray hot prick threshold value of a mouse, remarkably restrain mouse toe swelling caused by albumen and mouse high blood capillary permeability caused by acetic acid, remarkably relieve arthrocele of a rat with adjuvant arthritis, and reduce cross-section diameter of arthrosis; insect polypeptide anti-inflammatory and analgesic effective ingredients and TTS are expected to be used for preparing anti-inflammatory and analgesic biochemical drugs, are used for treating acute and chronic inflammation and relieving pains before and after various operations, preventing and treating pains accompanied by cosmetology, microscopic examination and burns, and easing acute and chronic pains such as neuropathic pain and cancer pain.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular, the present invention relates to a preparation method and medical application of an analgesic and anti-inflammatory effective fraction in Vespa heteroscens insects. The effective part is prepared from the crude bee venom of the genus Heterogastricus insects through modern extraction technology. Various transdermal absorption preparations of the effective part have significant effects on analgesia, anti-acute and chronic inflammation and autoimmune inflammation. It is expected that the effective part and its transdermal absorption preparation will be used for the preparation of anti-inflammatory and analgesic biochemical drugs, for the treatment of acute and chronic inflammation, as well as for various types of surgical pain relief, prevention and treatment of beauty, microscopic examination, pain associated with burns and scalds, neuropathic Pain and acute and chronic pain s...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/06A61K9/70A61K9/19A61K9/08A61K9/12A61K9/02A61P29/00A61P25/00A61P25/04A23L1/29A23L33/00
Inventor 肖培云李贵轲张成桂杨庭榜杨自忠赵昱
Owner DALI UNIV
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