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Application of velvet bean extractive on preparing anti-inflammatory analgesic drug

An anti-inflammatory and analgesic extract technology, applied in the field of anti-inflammatory and analgesic effects of extracts, can solve the problems of many adverse reactions, dependence and addiction

Inactive Publication Date: 2011-03-02
右江民族医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drugs used for anti-inflammation are mainly steroidal and non-steroidal anti-inflammatory drugs, and there are many adverse reactions.
And central analgesics such as morphine, pethidine, etc. are prone to dependence and addiction.

Method used

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  • Application of velvet bean extractive on preparing anti-inflammatory analgesic drug
  • Application of velvet bean extractive on preparing anti-inflammatory analgesic drug
  • Application of velvet bean extractive on preparing anti-inflammatory analgesic drug

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0013] One, the preparation of cat bean extract

[0014] The present invention uses the seed of Stizolobium cochinchinensis (Lour) Tang et Wang, which is a plant of the leguminous family Chenopodium genus, cat beans, as raw material, including white-skinned cat beans, black-skinned cat beans, flower-skinned cat beans or large Black skin type cat beans. The raw material is crushed or crushed after natural drying, soaked and extracted with an acidic solution with a pH of 1 to 4, and the alkaloid mixture of cat bean without levodopa is obtained through conventional separation, which is the cat bean extract of the present invention .

[0015] 2. Anti-inflammatory and analgesic activity of cat bean extract

[0016] (1) Anti-inflammatory effect experiment

[0017] 1. Experimental materials

[0018] (1) Drugs

[0019] Self-made cat bean extract is prepared with distilled water to make liquids with concentrations of 0.5%, 1%, and 2% before use, and adjust the pH to neutral.

[0...

Embodiment 1

[0070] The preparation of embodiment 1 oral liquid of the present invention

[0071] Take 1000 grams of cat beans, add 30 times the amount of acidic solution with a pH of 1 to 4, soak and extract for 24 hours, filter, take the filtrate, add 20 times the amount of distilled water to the filter residue, soak and extract for 24 hours, filter, combine the two filtrates, concentrate, concentrate The liquid is separated to remove levodopa, and the resulting levodopa-free solution is concentrated into a paste, dissolved in distilled water, adjusted to neutral pH, added with flavoring agents and preservatives, filled, sealed, and sterilized.

Embodiment 2

[0072] The preparation of embodiment 2 tablet of the present invention

[0073] Take 1000 grams of cat beans, add 30 times the amount of acidic solution with a pH of 1 to 4, soak and extract for 24 hours, filter, take the filtrate, add 20 times the amount of distilled water to the filter residue, soak and extract for 24 hours, filter, combine the two filtrates, concentrate, concentrate The liquid is separated to remove levodopa, and the obtained levodopa-free solution is concentrated into a paste, dried at 60°C, and an appropriate amount of starch and dextrin are added to the obtained cat bean extract, and 70% ethanol is added as a wetting agent, and mixed evenly to prepare Granules, dried, granulated, added with 1% magnesium stearate or talcum powder as lubricant, mixed evenly, compressed into tablets, and made into coated tablets each containing 100 mg of cat bean extract.

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Abstract

The invention belongs to the technical field of medicine, relating to the application of an extractive obtained from leguminosae mucuna plant velvet bean on preparing anti-inflammatory analgesic drug. In the invention, the anti-inflammatory action of the velvet bean extractive on the acute inflammation models of xylene-induced mouse ear edema and carrageenin-induced mouse toe swelling is observed, and the analgesic action of the velvet bean extractive on the model of mouse pain induced by hot plate and acetic acid is also observed. Experiments prove that the extractive has the anti-inflammatory analgesic action and can be used for preparing anti-inflammatory analgesic drug preparations. The prepared drug preparation contains the velvet bean extractive and one or more pharmaceutically acceptable pharmaceutic adjuvants, wherein the velvet bean extractive accounts for 1-95 wt% of the preparation. The drug preparation formulation comprises oral liquid, granules, capsules and injections.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the use of cat bean extract in anti-inflammatory and analgesic effects. Background technique [0002] Cat bean is the seed of Stizolobium cochinchinensis (Lour) Tang et Wang, a plant of the leguminous genus Stizolobium cochinchinensis (Lour) Tang et Wang. It is a characteristic medicinal and edible resource and a commercial crop in Guangxi. Cat bean is the most important raw material for extracting levodopa. Extracting levodopa from cat bean has become the main source of levodopa raw material in the world. At present, Guangxi has become an international production base of levodopa, and the cat bean planting-processing-breeding-planting industrial chain has initially formed in Guangxi. [0003] In recent years, people have made in-depth research on the technology of extracting and separating levodopa from cat beans, and the yield of industrialized large-scale production has reached 3.4%. H...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61P29/00A61K131/00
Inventor 黄增琼蒋伟哲许小林赖术潘勇黄兴振巫玲玲何显科施晓霞
Owner 右江民族医学院
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