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Analgesic and anti-inflammatory active site of Vespa insect, as well as preparation method and application thereof

A technology of effective parts and vespa, applied in the field of medicine, can solve problems such as failure to form large-scale production capacity and low level of industrial production support, and achieve the effects of inhibiting pain, reducing inflammation and immune inflammatory responses

Inactive Publication Date: 2014-03-19
DALI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with developed countries, there is still a relatively obvious gap in the research and development of my country's TTS system, especially the low level of supporting industrial production, which has not yet formed a large-scale production capacity

Method used

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  • Analgesic and anti-inflammatory active site of Vespa insect, as well as preparation method and application thereof
  • Analgesic and anti-inflammatory active site of Vespa insect, as well as preparation method and application thereof
  • Analgesic and anti-inflammatory active site of Vespa insect, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 : Preparation of effective parts of Vespa black shield venom and film-coating agent

[0044] 1.1 Collection of crude venom from Vespa black shield:

[0045] Black Shield Vespa was collected from Simao, Yunnan Province. The bee body specimen was identified as Vespa bicolor bicolor Fabricius (Black Shield Vespa) by Professor Mao Benyong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province. Wasp venom collection device: use the auxiliary cover type bee venom collector modified by the engineering research center, wooden frame, 80 cm long, 50 cm wide; embedded with 4 pieces of 20 cm long / 33 cm wide poisonous glass; input voltage 12V , output automatic intermittent pulsating voltage; method of collecting wasp venom: place the poison collecting device in front of the hive, and collect poison for 30 minutes according to the routine poison collecting procedure on the nest of Ves...

Embodiment 2

[0050] Example 2 : Preparation of effective parts of golden hornet bee venom and hydrogel, cataplasm and coating

[0051] 2.1 Collection of crude venom of golden hornet:

[0052] The golden hornets are collected from Lianghe County, Yunnan Province. The bee body specimen was identified as Vespa mandarinia Smith (also known as Golden Ring Vespa) by Professor Guo Yunjiao of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province. Wasp venom collection device: use the auxiliary cover type bee venom collector modified by the engineering research center, wooden frame, 80 cm long, 50 cm wide; embedded with 4 pieces of 20 cm long / 33 cm wide poisonous glass; input voltage 12V , output automatic intermittent pulsating voltage; method of collecting wasp venom: put the unpainted poison collector in front of the hive, and collect poison for 30 minutes according to the routine poison collection procedure...

Embodiment 3

[0061] Example 3 : Preparation of a coating agent for effective parts of Vespa dentatus venom

[0062] 3.1 Collection of crude venom from Vespa dentata:

[0063] Vespa dentatus was collected from Yunlong County, Dali Prefecture, Yunnan Province. The bee body specimen was identified as Vespa auralia Smith (vespa auralia Smith) by Professor Yang Zizhong of the National and Local Joint Engineering Research Center for the Development of Medicinal Special Insects, Dali University, Yunnan Province. The basic device for poison collection uses a sub-cap type bee venom collector modified by the engineering research center, with a wooden frame, 80 cm long and 50 cm wide; 4 pieces of poisonous glass with a length of 20 cm / width of 33 cm are embedded; the input voltage is 12V, Output automatic intermittent pulsating voltage; The wooden frame is painted red with red paint in advance; The wooden frame is pre-smeared with 20 milliliters of the honeycomb and honeycomb extract volatile solu...

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Abstract

The invention relates to an analgesic and anti-inflammatory active site of a Vespa insect, as well as a preparation method and application thereof. The active site is obtained by performing dialysis on crude wasp venom of a Vespa wasp by a dialysis membrane with MWCO (molecular weight cutoff) of 15KDa, and performing freeze-drying or decompression concentration drying on an eluate for preparation. A variety of percutaneous absorption preparations of the active site can effectively prolong the hot plate-stimulated pain threshold value and infrared heat tingling threshold value of mice and obviously inhibit the acetic acid-induced pain writhing response of the mice, as well as significantly inhibit xylene-induced ear edema of the mice, the egg white-induced toe swelling of the mice and the acetic acid-induced increased capillary permeability of the mice, significantly reduce the adjuvant-induced arthritis joint swelling of rats and reduce the joint circumference. The analgesic and anti-inflammatory active site of the insect and the percutaneous absorption preparations can be expected to be used for preparing anti-inflammatory and analgesic biochemical medicaments for treating acute and chronic inflammation, relieving pain before and after various operations and relieving pain and neuropathic pain accompanied by cosmetology, microscopic examination, burns and scalds, cancer pain and other acute and chronic pain.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular, the invention relates to a preparation method of an analgesic and anti-inflammation effective fraction in Vespa insects and its medical application. The effective part is prepared from the crude bee venom of Vespa vespa through modern extraction technology. Various transdermal absorption preparations of the effective part have significant effects on analgesia, anti-acute and chronic inflammation and autoimmune inflammation, which can be expected The effective part and its transdermal absorption preparation are used to prepare anti-inflammatory and analgesic biochemical drugs, to treat acute and chronic inflammation, and to relieve pain in various operations, cosmetology, microscopic examination, pain associated with burns, neuropathic pain, and Relief of acute and chronic pain such as cancer pain. The anti-inflammatory and analgesic biochemical drugs and their transdermal absorptio...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/06A61K9/70A61K9/19A61K9/08A61K9/12A61K9/02A61P29/00A61P25/00A61P25/04A23L1/29A23L33/00
Inventor 李春艳白玉宋志忠李合王静林巫秀美赵昱
Owner DALI UNIV
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