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Marker correlation visualization method and device

A marker and correlation technology, used in data visualization, bioinformatics, special data processing applications, etc., can solve problems such as complex spatial dimensions

Active Publication Date: 2015-04-29
SHENZHEN INST OF ADVANCED TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, when biological data contains tens of thousands or even hundreds of thousands of markers, the spatial dimension will be beyond the imagination of the mind

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  • Marker correlation visualization method and device
  • Marker correlation visualization method and device
  • Marker correlation visualization method and device

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Embodiment Construction

[0054] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0055] It should be noted that the terms used in the embodiments of the present invention are only for the purpose of describing specific embodiments, and are not intended to limit the present invention. As used in the embodiments of the present invention and the appended claims, the singular forms "a", "said" and "the" are also intended to include the plural forms unless the context clearly indicates otherwise. It should also be understood that the term "and / or" a...

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Abstract

The invention discloses a marker correlation visualization method and device. The marker correlation visualization method comprises calculating the fisher ratio of an i marker according to a plurality of sampling samples of the i marker; repeating the previous step until the fisher ratio of every marker is obtained; calculating the distance between the a marker and the b marker according to a plurality of sampling samples of the a marker and a plurality of sampling samples of the b marker; repeating the previous step until the distance between any two of the markers is obtained; serving the distance between every two of the markers and the dimension after dimension reduction as the input of a multidimensional scaling algorithm so as to obtain coordinate values of every marker; obtaining the size of every marker on a scatter diagram according to the fisher ratio of every marker and obtaining coordinates of every marker on the scatter diagram according to the coordinate values of every marker so as to enable the marker correlation to be visualized.

Description

technical field [0001] The present invention relates to the field of biotechnology, in particular to a marker correlation visualization method and device. Background technique [0002] Biological data such as gene expression profiles often have tens of thousands or even hundreds of thousands of markers, among which markers reflect the properties of chemical and biological substances in one aspect of biology. Correlation detection and analysis of these markers is the basis of many studies. In the prior art, a similarity matrix is ​​usually used in a two-dimensional space to express the relationship between markers. Among them, the row coordinate a and the column coordinate b of the similarity matrix are markers, and the element value of the ath row and bth column in the similarity matrix represents the similarity between the ath marker and the bth marker sex. There are often many measures of similarity, such as correlation coefficient, Euler distance, cosine function, etc....

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Application Information

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IPC IPC(8): G06F19/26G16B45/00
Inventor 周丰丰孟庆汉
Owner SHENZHEN INST OF ADVANCED TECH