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A kind of pharmaceutical composition for treating cerebrovascular disease

A technology for cerebrovascular diseases and compositions, applied in the field of medicine, can solve problems such as limited value

Active Publication Date: 2017-04-26
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most stroke drugs developed with a single antithrombotic and brain protection mechanism failed to pass the clinical trial verification. From this, the medical community realized that due to the complexity of the mechanism of cerebral ischemia-reperfusion injury, the single mechanism of stroke drugs The value is relatively limited, and research and development should seek more drugs with a "multi-target" mechanism of action

Method used

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  • A kind of pharmaceutical composition for treating cerebrovascular disease
  • A kind of pharmaceutical composition for treating cerebrovascular disease
  • A kind of pharmaceutical composition for treating cerebrovascular disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1. The effect of the combination of tristilbene on cerebral ischemia-reperfusion injury in rats

[0032] 1 medicine

[0033] 1.1 Test drug preparation

[0034] Take 6ml of water for injection respectively, heat to 80°C, add 2g of hydroxypropyl-β-cyclodextrin, stir to dissolve, add 150mg of tristilbene, polydipside, tristilbene derivatives and tristilbene respectively The composition was stirred to dissolve, 90 mg of sodium chloride was added for stirring and dissolved, and finally water for injection was added to 10 ml, and the pH value of the semi-finished product was measured (5.0-6.0) to obtain a 15 mg / ml solution, which was sequentially diluted to obtain a 3.75 mg / ml solution for use.

[0035] Positive control drug: Edaravone injection, source: Nanjing Xiansheng TECO Pharmaceutical Co., Ltd., batch number: 80-101207

[0036] Specifications: 5ml: 10mg, Properties: Colorless or almost colorless clear liquid, ready for use.

[0037] 1.2 Reagents

[0038] Re...

Embodiment 2

[0074] Example 2: Protective effect of tristilbene composition on nerve cell damage caused by hypoxia and glucose deficiency

[0075] 1 Experimental material

[0076] 1.1 Test sample

[0077] Preparation: After weighing an appropriate amount of tristilbene composition, add 0.01M PBS to the required volume to obtain a high-dose test product (1mg / ml); then filter and sterilize through a 0.2μm filter, and use PBS in a certain proportion for corresponding Dilute to obtain each dose of test substance.

[0078] 1.2 Positive Control 1

[0079] Name: Nimodipine

[0080] Source: Sigma

[0081] Lot number: SLBB1165V

[0082] Appearance: yellow powder

[0083] Preparation: Weigh an appropriate amount of sample and add DMSO to the required volume (3mg / ml); then filter and sterilize it through a 0.2 μm filter, and dilute it with PBS according to a certain proportion to obtain the required dose of the test product.

[0084] 1.3 Negative controls

[0085] Name: Sterile PBS

[0086] ...

Embodiment 3

[0123] Example 3: Mice maximum tolerated dose study of tristilbene composition

[0124] 1 Experimental material

[0125] 1.1 Test sample

[0126] Preparation: Take about 30ml of water for injection, heat it to 80°C, add 10g of hydroxypropyl-β-cyclodextrin, stir to dissolve, then add 3g of Tristilbene No. 1 composition, stir to dissolve, and then add 0.45g Sodium chloride is stirred to dissolve, and finally water for injection is added to make up to 50ml. After measuring the pH value (5.0-6.0) and content of the semi-finished product, it is finely filtered until it is clear and ready for use.

[0127] 1.2 Negative control

[0128] Name: Hydroxypropyl-β-cyclodextrin

[0129] Source: Kunming Pharmaceutical Group Co., Ltd.

[0130] Preparation: take about 30ml of water for injection, heat it to 80℃, add 10g of hydroxypropyl-β-cyclodextrin, stir to dissolve, then add 0.45g of sodium chloride and stir to dissolve, and finally add water for injection to make 50ml , After measuri...

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Abstract

The invention relates to the field of medicines and discloses a pharmaceutical composition and uses thereof. The composition comprises piceatannol 3'-O-glucoside, polydatin and a piceatannol 3'-O-glucoside derivative. Research found that the composition significantly improves the area of cerebral infarction and neurological functions after ischemia-reperfusion, fundamentally improves various damages caused by ischemia for patients with cerebrovascular diseases, has excellent treating functions for cerebrovascular diseases, and has a good clinical application prospect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition for treating cerebrovascular diseases. Background technique [0002] Cerebral ischemia is equivalent to "stroke" and "stroke" in traditional Chinese medicine. It is clinically divided into transient and persistent ischemic attacks. The latter includes cerebral thrombosis, cerebral thrombosis, and vasospasm. Cerebral ischemia can lead to neuronal damage and neurological dysfunction, and its neuronal damage includes acute neuronal necrosis and delayed neuronal apoptosis. It is one of the major diseases that endanger people's health worldwide and has received extensive attention from the international community. . In my country, the morbidity, disability and mortality of stroke, including cerebral infarction, remain high. [0003] At present, the treatment of cerebral ischemia mainly includes restoring cerebral blood flow, protecting neurons, and promoting the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7034A61P9/10A61P9/00
Inventor 龚云麒陈锦锌方芳周勇军
Owner KPC PHARM INC
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