Clostridium butyricum ucn-12 strain and its composition and application

Abstract

The invention discloses a new strain of Clostridium butyricum (Clostridium butyricum) UCN‑12 and its composition and use. The preservation number of the new strain in the General Microorganism Center of China Microbiological Culture Collection Management Committee is CGMCC No.9652. Using the fermentation culture of the bacterial strain of the present invention, the fermentation liquid or thalline obtained by centrifugation of the fermentation culture, and the dry matter of the fermentation liquid or thalline as active ingredients to feed livestock and poultry can treat and / or prevent Clostridium welchii of livestock and poultry Disease effect, the whole process does not need to add antibiotics, avoiding the pollution of antibiotic residues to the environment, can also significantly reduce the cholesterol and fat in poultry eggs, remove the fishy smell of poultry eggs, improve the flavor of eggs, improve the production performance of livestock and poultry animals, treat and / or Or prevent prenatal and postpartum constipation in sows, reduce livestock and poultry feces odor, and achieve a friendly breeding environment.

Description

Technical field [0001] The invention belongs to the field of microbiology, and relates to a strain of Clostridium butyricum UCN-12 and a composition and application thereof. Background technique [0002] Clostridium wilsonii, also known as perfringens disease, is one of the most common diseases of foodborne gastroenteritis. According to foreign statistics, the food poisoning caused by Clostridium wischii accounts for about 30% of the bacterial food poisoning. The latest statistics show that the number of food poisoning caused by Clostridium perfringens in the United States is about 250,000 each year, and the economic loss caused by 120 million Dollar. Epidemiological investigations have found that, on average, every outbreak of food poisoning caused by Clostridium perfringens usually involves 50-100 people. Some serious food poisoning outbreaks even involve thousands of people. [0003] Clostridium wischii can generally be divided into six types: A, B, C, D, E and F. Type A and ...

AI Technical Summary

Problems solved by technology

Due to the problem of drug resistance caused by long-term use of antibiotics, the use of antibiotics is getting higher and higher, but the treatment effect is getting worse and worse, and the environmental pollution is also increasing. In particular, the safety of drug residues is becoming more and more a concern of the whole society. The problem

Vaccine is a better way to prevent Clostridium welchii disease, but the protection period is short, and the cost is high, so it is unacceptable in production

[0006] Chinese patent application 201210390182.9 discloses a Chinese veterinary medicine for preventing and treating Clostridium welchii disease of piglets and a preparation method thereof. 5-15 parts, 10-20 parts of angelica, 10-20 parts of white peony, 1-5 parts of Panax notoginseng powder, 5-15 parts of ginseng stems and leaves, and 5-10 parts of licorice. This method is difficult to eliminate people's concerns about drug residues , and high cost

Patent application 201210552595.2 discloses a special feed containing Bacillus licheniformis, Bacillus subtilis, Enterococcus faecium, Streptococcus faecalis, and xylanase. Since Bacillus licheniformis and Bacillus subtilis interact with Enterococcus faecium and Streptococcus faecium, The compatibility of the composition is unreasonable, and the effect of this method is also poor

Patent applications 201310577204.7 and 201210261894.0 respectively disclose a strain of Bacillus subtilis and a strain of Bacillus licheniformis resistant to acid, heat, and bile salts to prevent and treat Clostridium welchii. The strains used are completely different from those of the present invention. Meanwhile, Bacillus subtilis and bacillus licheniformis belong to aerobic bacteria, need aeration culture, complicated process, and production cost is also higher than the present invention

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